56results about How to "Inhibit tumor metastasis" patented technology

Disclosed herein are methods of treating benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating a subject at risk of developing benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating or preventing recurrence of a tumor using an anti-VEGF-specific antagonist as well as use of VEGF-specific antagonists in neoadjuvant and adjuvant cancer therapy.

A Chinese herbal medicine for treating tumor comprises frankincense, myrrh, asarum, porcellio, azalea, strychnos alkaloids, scandent schefflera root, paniculate swallowwort, glabrous sarcandra herb, wooly datchmanspipe herb, unprocessed Radix Aconiti Kusnezoffii and unprocessed Semen Strychni which are added in the following proportion by weight part: 5-10 parts of frankincense, 5-10 parts of myrrh, 10 parts of asarum, 8-12 parts of porcellio, 1-3 pars of azalea, 1-2 parts of strychnos alkaloids, 50 parts of scandent schefflera root, 50 parts of paniculate swallowwort, 50 parts of glabrous sarcandra herb, 50 parts of wooly datchmanspipe herb, 10 parts of unprocessed Radix Aconiti Kusnezoffii and 8 parts of unprocessed Semen Strychni. The method for preparing the Chinese herbal medicine comprises the following steps: grinding frankincense, myrrh, asarum, porcellio, azalea, and strychnos alkaloids into powder; stewing scandent schefflera root, paniculate swallowwort, glabrous sarcandra herb, wooly datchmanspipe herb, unprocessed Radix Aconiti Kusnezoffii and unprocessed Semen Strychni into extract; and adding the medicinal powder into the stewed extract, stirring until uniformity appears, drying by using a heatable brick bed, grinding into 300 meshes of fine powder, and packaging with a capsule. The invention has the advantages that the medicine has no side effects, is not addictive, has no stimulative effects on digestive tract, and has the function of limiting tumor metastasis with low cost and easy production in large scale.

This invention relates to establishment of artificially reformed human adenovirus 5 and use in treatment of cancers by reorganized configuration of adenovirus. It is obtained by extension of fixed-point deficiency, homologous reorganization, transfection, and monoclone purification of adenovirus. Its novelty includes deletion of 9 alkali groups in encoding sequence of ADV 5 gene set E1A conservative sequence 2, deletion of 28532 - 29360nt of ADV 5 E3 with reversed inserting some of CHK1 cDNA segments. The reorganized configuration of adenovirus can selectively regenerate in tumors, with specific expression of reversed CHK1 cDNA segments to kill tumor cells but normal cells. The configuration is unique effectiveness in diagnosis and treatment of tumors. It provides an ideal therapy of gene target specifility.