Preparation and application of novel targeting peptide for specifically inhibiting tumor cell metastasis

Abstract

The invention relates to preparation and application of a novel targeting peptide for specifically inhibiting tumor cell metastasis. The preparation method disclosed by the invention is technically characterized in that a polypeptide TMTP1-GG-D(KLAKLAK)2 which can simultaneously identify high metastasis potential tumor cells and inhibit tumor cell growth and metastasis is prepared, and antimicrobial peptides can be specifically transported into malignant tumor tissues and local metastasis through the polypeptide, so that the high metastasis potential tumor cells can be selectively killed, an obvious toxic or side effect is avoided, the tumor growth and metastasis are effectively inhibited, the polypeptide is expected to become a novel antitumor medicine, and the key defects in the conventional tumor molecule targeted therapy technology and practice can be overcome. The invention aims to provide the polypeptide which can simultaneously and specifically identify and restrict tumor cells with high metastasis potential tendency, so that the problems of large side effects, low specificity and the like existing in existing targeting medicines are solved, highly-efficient and specific tumor inhibiting and killing effects are expected to be achieved in clinical treatment, and the treatment aim of greatly killing the tumor cells in a targeted mode can be furthest achieved due to the novel polypeptide. In addition, the invention also can provide a novel design mode for subsequent other molecular therapy.

Description

technical field [0001] The present invention relates to the preparation and application of a novel targeting peptide TMTP1-KLA that specifically inhibits tumor cell metastasis. Its technical feature is to prepare a polypeptide TMTP1-GG that can simultaneously identify tumor cells with high metastatic potential and inhibit tumor cell metastasis. - D (KLAKLAK) 2 , the polypeptide can selectively kill tumor cells with high metastatic potential without obvious toxic side effects, and effectively inhibit the growth and metastasis of tumors. The content of the invention belongs to the field of protein polypeptide. Background technique [0002] Malignant tumors are a class of diseases that seriously endanger human health. Definite evidence shows that more than 90% of malignant tumor patients eventually die of tumor metastasis or recurrence. In recent years, great progress has been made in tumor treatment, especially in the treatment of leukemia and malignant lymphoma. However, ...

AI Technical Summary

Problems solved by technology

Monoclonal antibodies designed against tumor antigens have become the most commonly used carriers in tumor-directed therapy, but the types of these monoclonal antibodies are very limited, and there are still the following disadvantages in practical applications: ① Large size, in tumor tissue, The penetrating power in the cells is weak, and can be taken up and phagocytized non-specifically by the liver and reticuloendothelial system; ② dose-related toxic effects on the liver and bone marrow; ③ strong immunogenicity

[0007] The purpose of the present invention is to provide a polypeptide that can specifically recognize and inhibit tumor cells with high metastatic potential at the same time, so as to overcome the problems of large side effects and low specificity of existing targeted drugs, and hope to be used in clinical treatment. highly effective and specific tumor suppressor and kill

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