The invention discloses a dendrobium wine and a preparation method thereof. 1 to 5 portions of raw dendrobium, 1 to 5 portions of ginseng, 1 to 5 portions of twotooth achyranthes root, 1 to 5 portionsof salvia miltiorrhiza bunge, 50 to 150 portions of sticky rice, 50 to 150 portions of water and 1.5 to 3 portions of qujiu medicine are weighed. After being steamed, the sticky rice is fermented for1 to 2 months by the qujiu medicine; after the fermentation is completed, the raw dendrobium, the ginseng, the twotooth achyranthes root and the salvia miltiorrhiza bunge are added, and distillationis carried out, thus obtaining the original wine. The original wine is blended, sterilized and bottled and then the finished product of the dendrobium wine is prepared. The doped drug is distilled, and is more beneficial to being absorbed and utilized by a human body by means of the effect of wine. By drinking commonly, the dendrobium wine has the functions of nourishing Yin, tonifying Yang, strengthening spleen, promoting appetite, protecting liver, benefiting gallbladder, clearing heat, moistening lung, strengthening muscles and bones, promoting circulation, reducing blood sugar, restrainingtumor, brightening eyes, moistening skin and prolonging life.