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Selenium-rich cordyceps militaris strain and application thereof

A technology of Cordyceps militaris and strains, applied in application, fungal products, medical preparations containing active ingredients, etc., can solve the problems of death, selenium tolerance and low biotransformation rate

Active Publication Date: 2015-01-21
海南森瑞谱生命科学药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the selenium in fungi is transformed in the body, most of it exists in the form of organic selenium, such as selenium polysaccharides and selenoproteins. It has high antioxidant and biological activity, and is very easy to absorb and utilize by the human body. It can be used as the best food for selenium supplementation , but the selenium content in the fruiting bodies of common Cordyceps militaris is low, about 0.1-20mg / kg, and its tolerance to selenium and biotransformation rate are low. In the medium with selenium concentration> 20mg / kg, bacteria The growth of silk and fruiting bodies are severely inhibited, even dead

Method used

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  • Selenium-rich cordyceps militaris strain and application thereof
  • Selenium-rich cordyceps militaris strain and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0048] The fruiting body artificial cultivation method of Cordyceps militaris (Cordyceps militaris) strain CM001 comprises the following stages:

[0049] (1) Mother species preparation: Inoculate Cordyceps militaris strain CM001 into PDA slant medium, temperature 22°C, air relative humidity 65%, dark culture for 7 days, select mycelia growth fast, neat strain as the mother species.

[0050] (2) Preparation of first-level liquid strains: Inoculate the selected good mother species into the strain liquid culture medium at a temperature of 22°C and a relative air humidity of 65%, and cultivate them in the dark with shaking for 7 days, and select mycelium balls neatly, about 2 in size. -3mm strains are used as first-class liquid strains.

[0051] (3) Preparation of secondary production strains: Inoculate the primary liquid strains into the strain liquid culture medium at a ratio of 6%, at a temperature of 22° C., and at a relative air humidity of 65%, and culture them in the dark ...

Embodiment 2

[0057] Cordyceps militaris (Cordyceps militaris) strain CM001 mycelial fermentation product, crushed, added 2 times the volume of distilled water to extract, added ethanol precipitation, after drying, the crude product of Cordyceps selenium polysaccharide was obtained, which can be used as the main product of antitumor and antiviral drugs raw material.

Embodiment 3

[0059] The fruiting body of Cordyceps militaris (Cordyceps militaris) strain CM001 is dried at 45°C, packed into bags or boxes, sealed, and can be eaten directly or made into tea for drinking.

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Abstract

The invention belongs to the field of microbial fungi, and relates to a selenium-rich cordyceps militaris strain CM001; the wild cordyceps militaris strain which is newly separated in the nature is selected as an original strain; the original strain is subjected to ultraviolet mutation, and the strain can be obtained by separating and screening; the selenium-rich cordyceps militaris strain is preserved in China General Microbiological Culture Collection Center (CGMCC) on July 18, 2014 with the preservation registration number of CGMCC No.9460, is named as CM001 and is named as cordyceps militaris in a classified way. Under the artificial culture conditions, the cordyceps militaris strain has the tolerance for high-concentration selenium, and can carry out biotransformation in a body; the hyphae yeast, the growth matrix or the sporocarp of the selenium-rich cordyceps militaris strain can be used as raw materials of medicines, foods and drinks, or can be prepared into powder, tablets, freeze-drying powder, capsules or electuary.

Description

technical field [0001] The invention belongs to the field of microbial fungi, and relates to a selenium-enriched Cordyceps militaris strain and its application. Background technique [0002] Selenium is an essential trace element for the human body, which can remove free radicals in the body, effectively prevent free radicals from damaging cells, and enhance the body's immunity. The Chinese Nutrition Society lists selenium as one of the 15 daily dietary nutrients, and each person should consume 50-250 micrograms of selenium per day. Moreover, studies have found that a daily intake of 200-400 micrograms of selenium also has the effect of inhibiting tumors. , so selenium is known as the "King of Cancer Prevention" and is an internationally recognized cancer suppressor. In 2003, the U.S. Food and Drug Administration (FDA) clearly stated: "Selenium can reduce the risk of cancer" and "Selenium can produce anti-cancer effects in the human body", and recognized selenium as a cance...

Claims

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Application Information

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IPC IPC(8): A01H15/00A01G1/04A23L1/28A23L1/30A61K36/066A61P35/00A61P37/04A61P31/12A23L31/00A23L33/10
Inventor 邓柳红张春发陈吉良唐权王桂玉黄超王胜
Owner 海南森瑞谱生命科学药业股份有限公司
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