The invention belongs to the field of
medicine processing, and specifically relates to a synthesizing technology of a
triazole derivative. The synthesizing technology provided by the invention is advantaged in that: the raw materials are easy to obtain, the time consumption is low, the condition is mild, and the yield is high. A technical scheme adopted by the invention comprises steps that: methanamide is added into a four-port flask provided with a stirrer, a constant-temperature
dropping funnel, a
distillation apparatus and a
tail gas absorbing apparatus; methanamide is heated to a temperature of 175-190 DEG C; hydrazine
hydrate is dropped into methanamide, wherein a
molar ratio of methanamide to hydrazine
hydrate is 1:1.1-1:2; the dropping is finished in 0.5-2.5h; emitted
ammonia gas is delivered into an absorbing
bottle to be absorbed, wherein the absorbing
bottle contains 20-30% H2SO4; when dropping is finished, the temperature is maintained for 0.5-2.5h; the materials are cooled; when a large amount of crystals are precipitated, the materials are subject to pump
filtration, such that a crude product is obtained; the crude product is washed by using
ethyl acetate, such that a target product 1H-1,2,4-
triazole is obtained. A yield is calculated, and a
melting point is detected.