The invention provides a preparation method of a
vitamin A ester intermediate C15 and
vitamin A ester. The method comprises the following steps: carrying out a
halogenation reaction and a cyclizationreaction on 3, 7-dimethyl-3-hydroxy-1, 6-octadiene as an initial
raw material, carrying out a
substitution reaction on the obtained product and
triphenylphosphine or triester phosphite to prepare a corresponding Wittig
reagent, carrying out a
Wittig reaction on the Wittig
reagent and 2-methyl-4-acetoxy-2-butenal, performing acidifying, hydrolyzing and acidifying the obtained product, and carryingout a
substitution reaction on the hydrolyzed and acidified product and
triphenylphosphine or triester phosphite to prepare C15. The
vitamin A ester can be prepared by carrying out a
Wittig reaction on the obtained C15 and 2-methyl-4-R3
substituent carbonyloxy-2-butenal. The method has the advantages of single
reaction type, easy operation and realization of
reaction conditions, safe and environment-friendly operation, simple post-treatment and low cost; and the reaction activity is strong, the reaction selectivity is high, the
atom economy is high, and the target product yield and purity arehigh.