The invention provides a preparation method of a multifunctional probe for tumor thermotherapy as a
magnetic resonance imaging contrast agent. The preparation method of the multifunctional probe comprises the following steps: dropwise adding the solution of
sodium diethyldithiocarbamate of water into the solution of a
copper compound in water, stirring to obtain a blackish brown precipitate which is diethyl dithio amino
copper, and
drying the precipitate in vacuum; adding a diethyl dithio amino
copper containing solution of
oleylamine into hot
oleylamine, introducing
nitrogen into the mixture, heating the mixture, stirring, cooling to
room temperature, washing, centrifuging, dispersing into a stabilizer, and evaporating in a rotating way; adding a surfactant, stirring, and filtering to obtain a transparent blackish green solution; adding
ethanol into the blackish green solution, oscillating ultrasonically, stirring, adding an alkali, a
silicon source and a magnetic compound, and stirring to form nanoparticles in core-shell structures. The probe heats tissues by adopting the
heat effect generated in the tissues of a
human body by a variety of physical energy such as microwaves,
radio frequency and ultrasonic
waves to accelerate the death of tumour cells, and the probe can be used as the
magnetic resonance imaging contrast agent.