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Masking-agent-containing test strip for detecting content of cadmium in Chinese herbal medicine

A technology of masking agent and Chinese herbal medicine, which is applied in the direction of material analysis by observing the influence of chemical indicators, and analysis by making materials undergo chemical reactions, etc., which can solve the problem that the masking agent is not suitable for precision requirements, reagents cannot be stored for a long time, test papers, etc. Eliminate the problems of easy oxidation and failure of strips, and achieve the effect of novel design, simple structure and long storage time

Active Publication Date: 2014-05-07
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that the test strips prepared by the conventional soaking method are easy to oxidize and fail, and cannot be stored for a long time
When carrying out the color reaction for the determination of heavy metal cadmium or lead, some literatures have applied some conventional masking agents to eliminate the interference of other metal ions, but they have not been applied to test strips because conventional masking agents are not suitable for test strips Accuracy requirements for detection; for this reason, there are almost no invention patents or literature reports on reagent strips with solidified masking agents applied
In addition, compared with the conventional chromogenic method, the reagents prepared in the conventional chromogenic method cannot be stored for a long time, and they need to be used and prepared immediately during the test.

Method used

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  • Masking-agent-containing test strip for detecting content of cadmium in Chinese herbal medicine

Examples

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preparation example Construction

[0037] The preparation of test strip of the present invention comprises the steps:

[0038] Step 1: Preparation of plastic substrates for loading. The material of the sample adding plastic substrate is polyvinyl chloride, polyethylene terephthalate, acrylonitrile-butadiene-styrene copolymer, etc., preferably a commercial polyvinyl chloride plate with a thickness of 75-180nm, width 8-12mm, length 25-40mm. Two circular holes are opened on the plastic substrate by punching, and the hole diameter is 4-6 mm. The distance between the centers of the two holes is 12-20mm.

[0039] Step 2: Preparation of fiberglass layer with heavy metal masking agent. The glass fiber membrane is a commercial glass fiber filter membrane made of 100% borosilicate glass fiber, with a thickness of 0.25 to 0.52 mm. The models include GFA, GFB, GFC, GFD, GFF, GF6, GF8, For GF9, GF10, etc., GFD is preferred. Described heavy metal masking agent formula has following types:

[0040] Masking agent formula...

Embodiment 2

[0066] Embodiment 2, the detection of cadmium element content in Poria cocos powder

[0067] 1. Preparation of test strips with heavy metal masking agent

[0068] In this embodiment, the plastic substrate for loading samples is a polyethylene terephthalate plastic plate with a thickness of 120 nm, a width of 10 mm, and a length of 30 mm. Two circular holes with a diameter of 5 mm are opened on the plastic substrate by punching. The distance between the centers of the two holes is 16mm.

[0069] When making the glass fiber layer of the heavy metal masking agent, a commercially available glass fiber filter membrane of model 6FA is used, with a thickness of 0.35mm. The masking agent recipe is a combination of recipe 2 and recipe 4. The preparation process is as follows: Weigh 0.5 g of sodium thiosulfate, 0.5 g of sodium citrate, 1.0 g of sodium potassium tartrate, and 1.0 g of thiourea, and the other manufacturing processes are the same as in Example 1.

[0070] When prepar...

Embodiment 3

[0078] Embodiment 3, the detection of cadmium element content in the reed root extract

[0079] 1. Preparation of test strips with heavy metal masking agent

[0080] In this embodiment, the plastic substrate for loading samples is an acrylonitrile-butadiene-styrene copolymer plate with a thickness of 180 nm, a width of 12 mm, and a length of 40 mm. Open two circular holes in the plastic substrate by punching, the hole diameter is 6mm. The distance between the centers of the two holes is 20mm.

[0081] When making the glass fiber layer of the heavy metal masking agent, a commercially available glass fiber filter membrane of type GF6 is used, with a thickness of 0.52 mm. The masking agent recipe is a combination of recipe 3 and recipe 5. The preparation process is as follows: Weigh 1.5 grams of thiourea, 1.5 grams of sodium pyrophosphate, 1.5 grams of sodium diethyldithiocarbamate, and 1.5 grams of o-phenanthroline, and the other production processes are the same as in Exam...

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Abstract

The invention discloses a masking-agent-containing test strip for detecting the content of cadmium in a Chinese herbal medicine. The test strip comprises a loading substrate, a glass fiber layer, a reaction substrate and a supporting substrate which are sequentially overlapped on one another, wherein the loading substrate is provided with a test hole and a contrast hole, the glass fiber layer contains a masking agent, the reaction substrate contains a cadmium color developing agent, and the supporting substrate is provided with two observation holes, and the two observation holes respectively correspond to the test hole and the contrast hole; the masking agent is the combination of two or more than two formulae in the following five formulae: a formula I including hydroxylamine hydrochloride and glycine; a formula II including sodium thiosulfate and sodium citrate; a formula III including thiourea and sodium pyrophosphate; a formula IV including sodium potassium tartrate tetrahydrate and thiourea; and a formula V including diethyl dithiocarbamate and phenanthroline. The test strip disclosed by the invention is convenient to carry, is simple to operate, low in cost, high in detection sensitivity and specificity and wide in application range and can realize the rapid spot detection on the heavy metal cadmium in the Chinese herbal medicine.

Description

technical field [0001] The invention relates to the technical field of rapidly detecting the content of cadmium in Chinese herbal medicines, in particular to a test strip with a masking agent for detecting the cadmium content in Chinese herbal medicines. Background technique [0002] The problem of excessive heavy metal content in Chinese medicinal materials has restricted the export of Chinese traditional medicine and entered the international market to a certain extent, damaged the image of Chinese traditional medicine, caused great economic losses, and seriously endangered the physical health of our people. China Trade News once reported that among the more than 30 kinds of unqualified medicinal materials exported to Germany by a Chinese traditional Chinese medicine group, the unqualified medicinal materials with excessive heavy metal content accounted for 34%. In 2008, the 18th issue of Chinese Journal of Traditional Chinese Medicine published a statistical analysis on t...

Claims

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Application Information

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IPC IPC(8): G01N21/78
Inventor 黄生权付萌柴春彦刘国艳唐青涛赵娜秦垂新
Owner INFINITUS (CHINA) CO LTD
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