As during the process of preparing asarin from 1, 2, 4-trimethoxybenzene, the raw materials of propionic anhydride, propionyl chloride, anhydrous aluminum chloride, anhydrous zinc chloride, dichloromethane, sodium borohydride, sodium propionate and the like with low prices are used, the production cost is lowered greatly. At the same time, the post treatment of the invention is convenient; products of each step are all solids which are convenient for detecting; the reaction yield of each step is high; and the production process generates few three wastes. In conclusion, in the invention, the 1, 2, 4-trimethoxybenzene which is obtained easily in China is used as a raw material to prepare the asarin by the reactions such as acidylation and the like; the invention has low cost, safe and simple operation, high reaction yield and less environmental pollution; and compared with the existing reported method, the invention is fit for the industrialized production better.