The invention discloses a cirrhosis ascites treatment medicine. The medicine comprises, by weight, 7-15 parts of rutin, 1-5 parts of benzbromarone, 11-19 parts of glycerol and 3-7 parts of naringin. The medicine is prepared through the following steps: mixing and grinding the benzbromarone and the glycerol, sieving the obtained mixture by a 120 mesh sieve, adding deionized water with the mass 3.7 times the total mass of the benzbromarone and the glycerol, heating the obtained solution to 81-83 DEG C, and stirring the solution at 81-83 DEG C for 36-39 min to prepare a mixture A; and adding naringin and rutin to the mixture A, carrying out ultrasonic treatment at 56 DEG C for 28 min, stirring the obtained mixture at 61 DEG C until the mixture is dry, and granulating the dry mixture. The total effective treatment rate of cirrhosis ascites reaches 98% or above, and the medicine improves the liver functions of patients, corrects hypoproteinemia, rapidly eliminates ascites, and reduces complications. The cirrhosis ascites treatment medicine has the advantages of simple and easily available raw materials, simple preparation technology, low production cost, good curative effect, fast effect, no toxic or side effects, and suitableness for large-scale production and promotion.