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Chitosan-nano laponite composite gel wound dressing and preparation method thereof

A composite gel and wound dressing technology, which is applied in the fields of medical formula, medical science, drug delivery, etc., can solve the problems of wound blackening, limit the popularization and use of nano-silver dressing, and not suitable for long-term use, so as to reduce pain, promote growth and Crawling of epithelial cells, beneficial effect on dissolution

Active Publication Date: 2017-10-20
湖北中创医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silver is a heavy metal element. When it is applied to a large area of ​​burns or pediatrics, the enrichment of silver ions will lead to poisoning phenomena such as blackening of the wound, so it is not suitable for long-term clinical use.
In addition, the shedding rate and release kinetics of nano-silver particles, the maximum area of ​​use of the human body and the cumulative use time, and the safety threshold of nano-silver need to be further studied, which limits the further promotion and use of nano-silver dressings.

Method used

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  • Chitosan-nano laponite composite gel wound dressing and preparation method thereof
  • Chitosan-nano laponite composite gel wound dressing and preparation method thereof
  • Chitosan-nano laponite composite gel wound dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] A kind of chitosan-nanometer lithium composite gel wound dressing, comprising the following raw materials in parts by weight: 3 parts of chitosan, 10 parts of nano lithium, 0.5 parts of sodium pyrophosphate, 1.5 parts of plasticizer, 15 parts of moisturizing agent, 80 parts of water.

[0023] The plasticizer is a mixture of sodium carboxymethylcellulose and hyaluronic acid with a mass fraction ratio of 3:3.

[0024] The humectant is glycerin.

[0025] The preparation method of this wound dressing comprises the steps:

[0026] 1) Take various raw materials in proportion;

[0027] 2) Take part of the water and add acetic acid to prepare an aqueous solution of acetic acid with a concentration of 1%. Dissolve chitosan in the aqueous solution of acetic acid, add a plasticizer and a humectant, and stir for 5 minutes at a temperature of 15° C. and a rotation speed of 200 rpm to obtain chitosan Sugar solution, the degree of deacetylation of chitosan is above 95%;

[0028] 3...

Embodiment 2

[0031] The difference between this embodiment and embodiment 1 is only: the preparation method of this wound dressing comprises the following steps:

[0032] 1) Take various raw materials in proportion;

[0033]2) Take part of the water and add acetic acid to prepare an aqueous solution of acetic acid with a concentration of 2%. Dissolve chitosan in the aqueous solution of acetic acid, add a plasticizer and a humectant, and stir for 2 minutes at a temperature of 10° C. and a rotation speed of 150 rpm to obtain chitosan Sugar solution, the degree of deacetylation of chitosan is above 95%;

[0034] 3) Add nano-lithium celite to the remaining water to prepare a 10% nano-lithium lithium aqueous solution, then add sodium pyrophosphate at a temperature of 15° C., and stir for 15 minutes at a speed of 180 rpm, then mix with the chitosan solution in step 2) , to obtain a homogeneous composite gel;

[0035] 4) Subpackage and sterilize the composite gel prepared in step 3).

Embodiment 3

[0037] The difference between this embodiment and embodiment 1 is only: the preparation method of this wound dressing comprises the following steps:

[0038] 1) Take various raw materials in proportion;

[0039] 2) Take part of the water and add acetic acid to prepare a 3% acetic acid aqueous solution, dissolve chitosan in the acetic acid aqueous solution, add a plasticizer and a humectant, and stir for 30 minutes at a temperature of 5 ° C and a rotational speed of 200 rpm to obtain chitosan Sugar solution, the degree of deacetylation of chitosan is above 95%;

[0040] 3) Add nano-lithium celite to the remaining water to prepare a 20% nano-lithium lithium aqueous solution, then add sodium pyrophosphate at a temperature of 25° C., and stir for 20 minutes at a speed of 160 rpm, then mix with the chitosan solution in step 2) , to obtain a homogeneous composite gel;

[0041] 4) Subpackage and sterilize the composite gel prepared in step 3).

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Abstract

The invention discloses a chitosan-nano laponite composite gel wound dressing and a preparation method thereof. The chitosan-nano laponite composite gel wound dressing is prepared from the following raw materials in parts by weight: 1 to 16 parts of chitosan, 0.6 to 20 parts of nano laponite, 0.1 to 0.5 part of sodium pyrophosphate, 1.2 to 3.5 parts of plasticizer, 8.5 to 20 parts of moisturizing agent, and 67 to 85 parts of water. The gel wound dressing is simple in preparation process and low in production cost; and by combining the chitosan and nontoxic nano laponite, the product has good biological compatibility, antibacteria and hemostasia performance and moisturizing performance, can effectively prevent the fat liquefaction of a wound, can promote the rapid healing of the wound, and has remarkable nursing effect for the wound that is difficult to heal or the scald wound.

Description

technical field [0001] The invention belongs to the technical field of medical wound dressings, and in particular relates to a chitosan-nanometer lithium composite gel wound dressing and a preparation method thereof. Background technique [0002] Wounds can be divided into acute wounds and chronic wounds according to time, and can be divided into superficial wounds and full-thickness wounds according to the depth of the skin involved in the injury. The reasons for delayed wound healing are mainly related to the patient's age, self-sensitivity, nutritional status, diabetes and other factors, while external factors may be related to the degree of wound damage, infection, and fat liquefaction. Therefore, to avoid delayed wound healing, certain wound care principles must be followed. First, we must control and reduce the factors that affect wound healing, and at the same time maintain the normal physiological environment of the local wound. Such requirements are based on the tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0066A61L26/0071A61L26/008A61L2300/102A61L2300/232A61L2300/404A61L2300/412A61L2300/418A61L2400/04C08L5/08C08L1/28
Inventor 张雨成宋炜韩振伟冯世忠张磊戴琦
Owner 湖北中创医疗用品有限公司
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