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Nano targeted transdermal method

A targeting and nanotechnology, applied in the field of biomedicine, can solve the problems of increasing the difficulty of tumor cells, high toxicity of sensitizing drugs, poor drug targeting, etc., to achieve increased biocompatibility, enhanced adhesion, and increased contact area. Effect

Inactive Publication Date: 2020-12-01
重庆珂蓝健康管理集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problems of anticancer drugs currently used in clinical practice include: high toxicity of sensitizing drugs, poor targeting of drugs, or daily radiotherapy combined with daily medication, which increases the inconvenience of clinical application, etc.
This increases the difficulty for tumor cells to internalize silica

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 A kind of nano target transdermal method

[0020] Raw materials: 160 parts of lecithin, 40 parts of bovine serum albumin, 10 parts of targeting polypeptide, 5 parts of ferrous sulfate;

[0021] The steps are as follows:

[0022] (1) The lecithin is dissolved in chloroform to make a lecithin chloroform solution, and the bovine serum albumin, targeting polypeptide, and ferrous sulfate are dissolved in water respectively to obtain a protein solution, a polypeptide solution, and an iron sulfate solution;

[0023] (2) The polypeptide solution and the protein solution were added to the lecithin chloroform solution, vortexed at a speed of 1000r / min for 20min, and 40kHz ultrasonicated for 10min to obtain a suspension A;

[0024] (3) Ferrous sulfate solution was added to solution A, vortexed at a speed of 1000r / min for 20min, and 80kHz was ultrasonicated for 20min to obtain suspension B;

[0025] (4) The suspension B was placed in a water bath at 40°C, stirred for...

Embodiment 2

[0027] Embodiment 2 A kind of nano target transdermal method

[0028] Raw materials: 200 parts of phospholipids, 50 parts of human serum albumin, 30 parts of targeting peptides, 5 parts of manganese sulfate and 10 parts of potassium ferrocyanide;

[0029] The steps are as follows:

[0030] (1) Lecithin is dissolved with chloroform-ethanol (volume ratio is 2:1) to make lecithin chloroform-ethanol solution, and the human serum albumin, targeting polypeptide, manganese sulfate and ferrous sulfate are dissolved in water respectively to obtain Protein solution, polypeptide solution, manganese sulfate solution, ferrous sulfate solution;

[0031] (2) The polypeptide solution and the protein solution were added to the chloroform-ethanol solution of the phospholipid, vortexed at a speed of 1500r / min for 10min, and 80kHz ultrasonicated for 20min to obtain a suspension A;

[0032] (3) Add the manganese sulfate solution and the sulfuric acid sub-solution into solution A, vortex and osci...

Embodiment 3

[0035] Embodiment 3 A kind of nano target transdermal method

[0036] Raw materials: 250 parts of lecithin, 60 parts of soybean albumin, 50 parts of targeted polypeptide, 3 parts of potassium ferrocyanide, 4 parts of ferric chloride and 1 part of manganese sulfate;

[0037] The steps are as follows:

[0038] (1) The lecithin is dissolved with cyclohexane to make a lecithin cyclohexane solution, and the soybean albumin, targeting polypeptide, potassium ferrocyanide, ferric chloride, and manganese sulfate are dissolved in water respectively to obtain protein Solution, peptide solution, potassium ferrocyanide, ferric chloride solution, manganese sulfate solution;

[0039] (2) The polypeptide solution and the protein solution were added to the lecithin cyclohexane solution, vortexed at a speed of 3000r / min for 5min, and ultrasonicated at 100kHz for 20min to obtain a suspension A;

[0040](3) Add the manganese sulfate solution and sulfuric acid sub-solution into solution A, vorte...

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PUM

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Abstract

The invention provides a nano targeted transdermal method. The nano targeted transdermal method comprises lecithin, a soluble protein, a targeted polypeptide and a soluble metal salt. The method comprises the following steps: dissolving lecithin with an organic solvent to prepare a lecithin solution, and respectively dissolving the soluble protein, the targeted polypeptide and the soluble metal salt with water to prepare a protein solution, a polypeptide solution and a metal salt solution; adding the protein solution and the polypeptide solution into the lecithin solution, and performing vortex oscillation and ultrasonic treatment to obtain a solution A; adding the metal salt solution into the solution A, and performing vortex oscillation and ultrasonic treatment to obtain a solution B; sealing the solution B, performing stirring and heating in a water bath, performing vortex oscillation and ultrasonic treatment, then adding pure water, and performing rotary evaporation to remove the organic solvent to obtain a transparent nano targeted preparation body solution; and freeze-drying the transparent nano targeted preparation body solution. The method has the advantages that the raw materials are simple and easy to obtain, the preparation process is simple, the large-scale industrial production can be achieved, the cost is low, and the applicability is wide.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a nano-target transdermal method. Background technique [0002] Cancer is currently the most common major disease that seriously threatens people's health and life. The current drug treatment of cancer still faces many bottlenecks, such as high recurrence rate, rapid drug resistance, high toxic side effects, low drug efficacy, etc. . The current problems of anticancer drugs in clinical use include: high toxicity of sensitizing drugs, poor targeting of drugs, or daily radiotherapy combined with daily medication increases the inconvenience of clinical application, etc. Taking cisplatin as an example of an anticancer drug, the drug itself has a good anticancer effect and can be used as a first-line chemotherapy drug. At the same time, cisplatin is a highly effective radiosensitizer, which can significantly enhance the radiotherapy effect. However, while cisplatin kills tumor c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/19A61K47/02A61K47/42A61K47/64B82Y5/00
CPCA61K47/64A61K9/19A61K47/42A61K9/0014A61K9/1271A61K47/02B82Y5/00
Inventor 房俊英
Owner 重庆珂蓝健康管理集团有限公司
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