97 results about "Pyrimethamine / Sulfadiazine" patented technology

A detection method simultaneously detects residue of multiple synthetic antibacterial agents in aquatic products by a high performance liquid chromatography. The synthetic antibacterial agents mainly comprise sulfadiazine SD, sulfamerazine SMR, sulfadimidine SDD, sulfadimethoxine SDM, furazolidone FZD, oxolinic acid OXA, nalidixic acid NAA and the like. The multiple synthetic antibacterial agents in an aquatic product sample are extracted by acetonitrile, degreased by normal hexane, concentrated, purified by a solid phase extraction column (alumina neutral) or a C18 solid phase extraction column, analyzed by a liquid chromatograph, detected by an ultraviolet detector, and quantified by an external standard method. The method can quickly, sensitively and accurately detect multiple target compounds to greatly reduce detection cost and shorten detection time.

The invention discloses a mixed bacterial agent capable of degrading antibiotics in soil, belonging to the field of microbial technology. The mixed bacterial agent is prepared by mixing Bacillus subtilis J5P2 and Pseudomonas J2 according to a volume ratio of (0.1-3): 1. A preparation method for the mixed bacterial agent comprises the following steps: I, preparation of a suspension; II, colony culture: (1) preparation of a medium and (2) culture; III, separation of strains; IV, subculture and domestication: (1) domestication, (2) preparation of a LB medium, and (3) preservation; V, preparation of inoculum liquid; and VI, preparation of the mixed bacterial agent. The mixed bacterial agent provided by the invention has the characteristics of capacity of effectively degrading a plurality of residual antibiotics in soil and reducing environmental pollution, etc., and can be used for the remediation of land contaminated by antibiotics such as tetracycline, penicillin, sulfadiazines and quinolones.

The invention provides a preparation method of a nano carrier for tumor photo-dynamics therapy (PDT). According to the preparation method, Fe<3+> salts are dissolved in DMF, then a photo-sensitizer (TCPP) is added to obtain particles (NMOFs); then the particles are dispersed in water under the assistance of ultrasonic waves; crosslinking agents (EDC and NHS) are added; after the reactions betweenBSA and sulfadiazine (SDs) finish completely, dialysis is performed to obtain particles (NMOFs@BSA / SDs); then the particles are dispersed in distilled water, then Mn<2+> salts are added, the pH is adjusted, and finally dialysis is performed to obtain a carrier (NMOFs@BSA / SDs@MnO2). Nano metal organic framework particles are taken as the basis and coated by protein (BSA) and sulfadiazine (SDs); finally the particles are in-situ mineralized to obtain required particles; SDs can specifically recognize carbonic anhydrase of tumors and is capable of actively targeting the oxygen-deficient parts oftumors; MnO2 generated in mineralization can catalyze the H2O2 decomposition to increase the oxygen content of tumors; and the PDT efficiency is improved.

The present invention relates to a method for determining 10 kinds of antibiotics in a water environment through combination of a sample pre-treatment technology and HPLC-MS, and belongs to the field of detection of safety of trace organic contaminant residue in the water environment. The method is characterized in that a water sample is separated and enriched through combination of solid phase extraction and dispersive liquid-liquid microextraction (SPE-DLLME), and then an ultra-high performance liquid chromatography-mass spectrometry instrument (UPLC-MS / MS) is adopted as a detection tool to directly determine the contents of 10 kinds of common antibiotics in the water environment (drinking water, tap water, river water, sewage treatment plant influent and effluent), wherein the 10 kinds of the common antibiotics respectively are sulfadiazine, sulfamethoxazole, oxytetracycline, tetracycline, doxycycline, ciprofloxacin, levofloxacin, chloramphenicol, cefuroxime axetil and tinidazole. According to the present invention, the water sample pre-treatment method and the instrument detection conditions are investigated and optimized, and the optimal SPE-DLLME-UPLC-MS / MS method is established and is successfully applied for the real sample determination; and compared with the traditional method, the method of the present invention has advantages of high sensitivity, high extraction recovery rate, wide application objects, environmental protection, and the like.

The invention relates to a method for measuring 12 types of remaining medicine in a water environment through separation and enrichment at the same time, and belongs to the field of safety detection of a trace of organic pollutant residue in the water environment. The content of 12 types of frequently-used medicine in the water environment (drinking water, faucet water, river water and water discharged into and out of sewage treatment plants) is directly measured with an ultra performance liquid-chromatography-mass spectrometer (UPLC-MS / MS) as a detection tool after a water sample is subjected to solid phase extraction combined with ultrasonic-assisted dispersion liquid-liquid micro-extraction (UA-DLLME) separation and enrichment. The 12 types of antibiotic include ketoprofen, ciprofloxacin, tinidazole, tolfenamic acid, sulfadiazine, sulindac, naproxen, sulfamethoxazole, chloramphenicol, cefuroxime axetil, piroxicam and mefenamic acid. Inspection and optimization are conducted on a sample pretreatment method and instrument detection conditions of the water sample, and the optimal UA-DLLME method is established and is successfully applied to practical sample detection. Compared with a traditional method, the method has the advantages of being high in sensitivity, high in extraction and recycle rate, wide in suitable object, friendly to the environment, and the like.

The invention provides a biotin-labeled sulfadiazine nucleotide aptamer. The biotin-labeled sulfadiazine nucleic acid aptamer is characterized by comprising a probe, wherein the nucleotide sequence of the probe is S-SDZ No.1. The kit and the method provided by the invention have the advantage of speediness, stability and simpleness in detection, and the prepared nucleotide aptamer is rapid in SDZ residue detection, high in sensitivity, good in repeatability and high in specificity, and has a wide application prospect in rapid detection of food safety.

Disclosed is a compound sulfonamide turbid agent which comprises the following constituents (by weight percent): sulfadiazine 8-12, sulfamethoxazole 4-8, sulfamethoxydiazine 2-6, trimethoprim 2-6, and medicinal auxiliary materials including acid-base scale modifier, suspension auxiliary agent, acidifying agent, anti-oxidant, stabilizer and purified water.

The invention relates to the technical field of environment detection and is suitable for measuring erythrocin, chloramphenicol, sulfamethoxazole, sulfadiazine, roxithromycin, cefotiam, pyridazol, norfloxacin, ofloxacin, tetracycline and doxycycline in sewage, surface water and bottom mud. After being sampled, a water sample and a mud sample are pretreated and detected through ultra-high performance liquid chromatography-triple quadrupole mass spectrometry, and qualitative diagnosis is conducted through the characteristic ion pair (m / z) of a target compound, a standard curve is drawn accordingto the response value and the corresponding concentration, and the external standard method is used in quantification, so that the contents of various antibiotics in the sample are obtained. The method is accurate, sensitive and simple, and is suitable for measuring the contents of 11 typical antibiotics in the sewage, the surface water and the mud at the same time.

The invention belongs to the field of xenogenic acellular dermal matrixes and preparation methods thereof. The preparation method of a freeze-thawing xenogenic laser microporous irradiated acellular dermal matrix is characterized by comprising the following steps: chipping a skin graft of piglet skin, and drawing the skin graft; perforating with laser; cleaning by adopting a buffer solution; performing freeze-thawing, and adding the buffer solution which is enough to immerse the skin graft for ultrasonic oscillation so as to remove destroyed dead cells and cell debris to maintain the completeness of structure and base membrane in acellular derma; cleaning with purified water, adding sulfadiazine zinc less than or equal to 0.12mg / cm<2>, and freezing at minus 20 DEG C; and sealing, disinfecting and sterilizing. The freeze-thawing xenogenic laser microporous irradiated acellular dermal matrix prepared with the method is characterized in that: the thickness is between 0.3mm and 0.4mm, the pitch is between 1.0mm and 2.0mm, and the pore diameter is between 500um and 808um.

The invention provides a sheath-core composite photocatalytic fiber and a method for preparing the same. The method includes steps of placing sheath-core composite polyester fibers in composite photocatalyst solution and carrying out padding treatment on the sheath-core composite polyester fibers; sequentially carrying out first heat treatment and second heat treatment on fibers obtained by means of padding treatment so as to obtain the sheath-core composite photocatalytic fiber. The sheath-core composite photocatalytic fiber and the method have the advantages that composite photocatalysts can be firmly attached onto the sheath-core composite polyester fibers by the aid of the padding treatment, polyester of core layers can have certain viscosity after the fibers are subjected to the first heat treatment and the second heat treatment, and accordingly excellent adhesion effects can be realized for the composite photocatalysts; as shown by experimental results, the sheath-core composite photocatalytic fiber is high in sulfadiazine degradation rate, and all sulfadiazine can be degraded by the sheath-core composite photocatalytic fiber in 5 hours approximately; the sulfadiazine degradation activity of the sheath-core composite photocatalytic fiber is hardly changed after the sheath-core composite photocatalytic fiber is reused by 20 times, and accordingly the sheath-core composite photocatalytic fiber is excellent in photocatalytic stability.

The invention discloses a preparation method and application of sulphonamide molecular-imprinting solid-phase extraction columella. The preparation method comprises the following steps of: (1) mixing a template molecule, a functional monomer and a cross-linking agent; (2) representing molecular-imprinting polymer particles; (3) filling the molecular-imprinting polymer particles into a solid-phase extraction columella, wetting and washing by using methanol and acetone, sealing in vacuum, wherein the sulphonamide molecular-imprinting polymer is obtained by the following steps of: (a) dissolving the template molecule sulfanilamide and the functional monomer in pore-foaming agent acetonitrile to obtain a mixed solution; (b) carrying out ultrasonic treatment onto the mixed solution by an ultrasonic cleaner to obtain a pre-polymerization system; (c) transferring the pre-polymerized system to a quartz reaction test tube, adding cross-linking agent and imitator; (d) placing the pre-polymerization system under ultraviolet light; (e) directly grinding the imprinted polymer to obtain the imprinted polymer particles. The preparation method of the sulphonamide molecular-imprinting solid-phase extraction columella is high in recovery rate, simple to prepare, low in cost and capable of being directly used for selective adsorption and efficient enrichment of sulfadiazine, sulfamerazine and sulfadimidine in animal-origin food.

The invention discloses a method for removing antibiotic-sulfadiazine in water through activated carbon fiber adsorbent. The method comprises the steps that the activated carbon fiber adsorbent is placed into water containing antibiotic-sulfadiazine according to the certain placing amount, vibration adsorption is carried out at set temperature, the treated water is filtered after vibration adsorption is finished, activated carbon fiber adsorbing antibiotic-sulfadiazine is separated from the treated water, and therefore the antibiotic-sulfadiazine in the water is removed. The method can effectively remove antibiotic-sulfadiazine in water, and meanwhile has the advantages of being high in removal efficiency, resistant to corrosion and heat, beneficial to separation and the like. The absorbent preparation process is simple, low in cost, low in energy consumption and quite good in application prospect. The method for removing sulfadiazine through the activated carbon fiber is low in energy consumption, economic and environmentally friendly, has the certain industrial development potential and provides a new thought for removing sulfadiazine.

The invention relates to a selective coloration culture medium for fast culturing and identifying clostridium perfringens. The selective coloration culture medium is characterized in that the preparation of 1000ml of the culture medium requires 12.0g-20.0g of casease hydrolysate, 6.0g-12.0g of yeast extract powder, 0.20g-0.80g of sodium sulfite, 0.005g-0.015g of polymyxin B, 0.05g-0.20g of sulfadiazine, 0.20g-0.80g of ferric citrate, 4-12 units of Y.S.N. and 10.0g-18.0g of agar powder and also requires the final addition of distilled water till the volume of 1000ml is achieved. The selective coloration culture medium has the advantages that the culturing time is obviously reduced when being compared with a conventional method and other bacteria with the same culturing characteristics are inhibited and do not grow so that the effect of fast clostridium perfringens culturing and identification can be realized.

The invention discloses a compound sulfadiazine injection and a preparation method thereof. The compound injection comprises the following components in parts by weight: 5-12 parts of sulfamonomethoxine sodium, 1-5 parts of trimethoprim (TMP), 0.1-0.3 part of anhydrous sodium sulfite, 0.01-0.05 part of disodium ethylene diamine tetraacetate, 8-10 parts of sulfamethoxazole, 20-50 parts of propylene glycol, 1-5 parts of ethanolamine and 45-79 parts of injection water. Compared with the single sulfamonomethoxine sodium, the compound preparation prepared from the sulfamonomethoxine sodium, the sulfamethoxazole and the TMP expands an antibacterial spectrum, enhances the curative effect of the injection and enlarges the clinical application range; and the compound preparation can be applied to treating infection caused by bacteria as well as fever, high fever and dyspnea caused by toxoplasma, and the preparation has better treatment effect on diseases such as appetite decrease and even anorexia, diarrhea and the like.

The invention provides an oral liquid preventing and curing gallinaceous leucocyto zoonosis and a preparation method thereof. The oral liquid comprises sulfadiazine, TMP, aluminum stearate, alcohol, sodium carboxymethyl cellulose, and Tween -80. The concrete preparation method comprises the following steps that: (1) the aluminum stearate is porphyrized, to which the alcohol is added, (2) the sulfadiazine and the TMP are added to the solution of the step (1), (3) distilled water is taken and stirred evenly, (4) the Tween -80 is added and stirred evenly, (5) the sodium carboxymethyl cellulose is taken and is mixed into paste with the distilled water and the paste is added to the solution of the step (4) to be mixed well, and (6) anhydrous sodium sulfate is added and dissolved, the distilled water is added and stirred evenly, the pH value is adjusted to 9.5 to 11.5 with 0.5 percent of sodium hydroxide water solution and the product is obtained. The oral liquid adopts the suspension technology. The slightly soluble sulfadiazine and TMP are made into suspension liquid. The procedure of stirring feed is left out. The use is convenient and the efficacy is obvious.

The invention relates to a method for degrading sulfadiazine in water by activating persulfate with coagulated sludge. The method comprises the following steps: 1, preparing a persulfate activator: carrying out natural air-drying, crushing, drying, crushing and sieving on the coagulated sludge; taking the crushed sludge, adding the crushed sludge into a tubular furnace, pyrolyzing the sludge in anitrogen atmosphere, and cooling the obtained pyrolysis product to obtain a black carbonized material; and 2, acting persulfate with the prepared carbonized material to treat sulfadiazine wastewater:adding carbonized material to the sulfadiazine wastewater, carrying out a reaction on a shaking table at room temperature, adding the persulfate, and continuing the reaction under the above conditions, wherein a detection result shows that the method has a high removal rate. The method has the advantages of realization of recycling of wastes by using the coagulated sludge as a main raw material, simple and easy preparation process, low cost, and great application prospect in the removal of antibiotics and other refractory organic pollutants.

The invention relates to a preparation method and application of a molecularly imprinted polymer of sulfadiazine for controlled catalytic degradation, belonging to the technical field of material preparation and pollution control of water environments. The molecularly imprinted polymer of sulfadiazine for controlled catalytic degradation is prepared according to the steps of preparation of a substrate material of a molecularly imprinted controlled catalytic material by loading catalytic inorganic nanoparticles on a surface of a silica nanosphere, and coating of a layer of imprinted polymer on the surface of the silica nanospher by a controlled polymerization technology. When observed through a transmission electron microscope, the catalytic material has a uniform microstructure and good dispersibility. The catalytic degradation capability of the catalyst is evaluated by a static catalytic degradation experiment. Experimental results show that the catalyst has certain selective catalytic degradation capability for sulfadiazine and good regeneration performance and can be used in certain potential applications.

The invention relates to a strip dyeing method for corn fibers. The method comprises the following processes of: 1, dyeing, namely filling the corn fiber strips into a dye vat, rotating the dye vat, adding polyol ester liquid into the dye vat, rotating the dye vat, adding a carrier, namely polyolefin elastomer (POE) liquid, into the dye vat, rotating the dye vat, adding univadine diiodofluorescein (DIF) into the dye vat, rotating the dye vat, adding univadine DPS into the dye vat, rotating the dye vat for minutes, adding a disperse dye, namely Terasil sulfadiazine (SD), into the dye vat, rotating the dye vat, starting to raise the temperature to 70+ / -2 DEG C at the temperature rise speed of 1.5 to 2 DEG C per minute, raising the temperature to 90+ / -2 DEG C by keeping the temperature rise speed at 1 DEG C per minute, keeping the temperature for 10 seconds, raising the temperature to 110+ / -2 DEG C at the temperature rise speed of 1 DEG C per minute, keeping the temperature for 20 to 30 minutes, lowering the temperature to 50+ / -2 DEG C at the temperature descent speed of 2 DEG C per minute, and discharging the liquid; and 2, performing post treatment, namely adding the dyed corn fiber into the dye vat, adding soaping liquid 209, sodium bicarbonate and sodium hydrosulfite into the dye vat, raising the temperature to between 60 and 65 DEG C, keeping the temperature for 15 to 20 minutes, and discharging the liquid. The homochromatism, the dyeing uniformity and the stability of dyeing are improved by the method; the dyeing effect is good; and the color fastness is good. The injury to the fibers in the dyeing process is low.

The invention discloses a making method of macromolecular aquagel dressing of sulfanilamide pyrimidine salt, which comprises the following steps: dissolving N, N'-methylene diacrylamide into acrylic acid completely; dripping sodium hydroxide solution into acrylic acid; adding polyvinyl alcohol solution and chitose acetic acid solution; stirring evenly to obtain solution A; dispersing sulfanilamide pyrimidine salt powder into glycerin to obtain solution B; blending potassium persulfate solution and residual water completely to obtain solution C; dripping solution A in the solution B; stirring evenly; adding solution C; pouring into mould; heating to obtain the product to treat burn.

The invention provides quick-acting scarless burn and scald ointment. The ointment comprises the following components in weight proportion: the ratio of rheum officinale: tendril-leaved fritillary bulb: compound sulfamethoxazole: sulfadiazine: gentamicin: borneol: bark oil: Vaseline: cefradine is (15-25):(8-12):(10-20):(0-12):(2-6):(3-8):(5-7):(85-125):(0-1). The drugs are weighed and mixed in specified amount, are grinded and mixed to prepare the ointment. The burn and scald ointment can treat various burn and scald wounds, has short course of treatment, and scars cannot be left after healing.

The invention relates to a method for simultaneously screening multiples categories of drug residues in fish by using ultra performance liquid chromatography-quadrupole rod time-of-flight mass spectrometry. The multiples categories of drugs screened simultaneously comprise enrofloxacin, danofloxacin, tetracycline, oxytetracycline , chlortetracycline, doxycycline, chloramphenicol, thiamphenicol, florfenicol, sulfamethoxazole, sulfamethoxazole, sulfathiazole, sulfadiazine, sulfadoxine, sulfisoxazole, sulfaphenirazole, sulfacetamide, sulfamethazine, azithromycin, tilmicosin, medimycin, roxithromycin, acetylspiramycin, doramectin, sudan I, sudan II, sudan III, sudan IV and rhodamine B. By optimizing the parameters of a d-SPE pretreatment method, all target drugs can obtain good recovery rates.29 kinds of target drugs are simultaneously screened by an optimized chromatographic mass spectrometry condition, thereby achieving simultaneous screening of common multiples categories of drug residues in fish. The method has a good application prospect in the field of fish food.

The present invention belongs to the field of medical dressing technology, is especially the technology of biological skin as foreign substituting skin, and aims at provides biological skin processing method to improve the performance of biological skin, including abacterial performance, no repulsion reaction and even high cell activity and biological affinity. The SD-Zn irradiated biological skin is made with piglet skin, has thickness of 0.2-0.5 mm and contains sulfadiazine zinc. Its preparation process includes the steps of : taking piglet, scraping to eliminate hair, cutting, defatting, cutting to 0.2-0.5 mm thickness, washing, soaking in medicine solution of sulfadiazine zinc, packing, irradiating and cold storing.

The invention discloses a sodium sulfadiazine compound preparation for treating pig brain hydropsy, and a preparation method and application thereof, and belongs to the technical field of veterinary medicines. The sodium sulfadiazine compound preparation comprises sodium sulfadiazine, mannitol, furosemide, trimethoprim and the like. The sodium sulfadiazine compound preparation is scientific and reasonable in formula, safe in auxiliary material, controllable in quality, high in stability and low in cost, and a preparation process is simple and is suitable for industrial production.

The invention provides a sulfadiazine rapid release tablet. The sulfadiazine rapid release tablet comprises a sulfadiazine active ingredient as well as one or more of a filler, a disintegrating agent, a binding agent, a lubricating agent, a flow aid, a flavouring agent, a smell reducing agent and a colouring agent and further comprises a release accelerator which can promote release of the active ingredient. The release accelerator can be selected from the following substances: lauryl sodium sulphate, poloxamer, Twain, cetyltriethyl ammonium bromide, sodium laurylsulfate, sodium stearyl sulfonate, polyoxyethylene higher aliphatic alcohol, sucrose ester, sorbitol fatty ester, soybean phospholipil, alginic acid, sodium alga acid and aluminium-magnesium silicate colloid, and usage amount of the release accelerator accounts for 0.1-5% of the total weight of the sulfadiazine rapid release tablet.

The embodiment of the invention discloses ointment for treating bedsore, diabetic wound and scald. The ointment comprises the following components in percentage by weight: 1.5 to 6.5 percent of sulfanilamide crystal, 1.5 to 6.5 percent of sulfadiazine, 2.0 to 10.0 percent of zinc oxide, 0.4 to 4.0 percent of cod liver oil, 0.1 to 3.0 percent of racanisodamine, 0.02 to 1.4 percent of borneol, 5.0 to 30.0 percent of herba violae, and the balance of medical vaseline. By adopting the ointment, tissue permeability at the afflicted part of a patient can be enhanced, moisture evaporation of the ointment is reduced, the acting time of the medicament at the afflicted part is prolonged, bacteria at the afflicted part are inhibited, local microcirculation is obviously improved, discontinuity during capillary blood perfusion is avoided, and healing of the afflicted part is promoted.

The invention discloses a method for simultaneous determination of nine sulfonamide antibiotics on suspended particles in water. The method comprises the following steps: taking a target water sample,filtering, and collecting a filtered membrane and particles retained on the surface; adding a quantitative internal standard substance; cutting and placing in a centrifuge tube after freeze drying; adding an appropriate amount of extractant; performing constant temperature oscillation, ultrasonic treatment and centrifuging; transferring supernatant to a K-D concentration bottle; purging the extraction liquid to less than 1ml by nitrogen gas; filtering with an organic microporous filter membrane; and measuring with an ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometer. The method has the advantages of short sample pretreatment time, simple steps, simultaneous determination of the contents of nine sulfonamide antibiotics such as sulfadiazine, sulfapyridine, sulfamethazine, sulfisomidine, sulfachlorpyridazine, sulfamerazine, sulfamethoxazole, sulfaquinoxaline and trimethoprim adsorbed on the suspended particles in water, and more accurate and true reflection of the contents of the sulfonamide antibiotics in water more.

The invention provides a hybridoma cell strain NaN-1 secreting a monoclonal antibody resistant to sulfonamide antibiotics (SAs) and an application thereof, belonging to the field of food safety immunodetection. The hybridoma cell strain NaN-1 secreting the common monoclonal antibody capable of identifying 25 SAs is collected in the China General Microbiological Culture Collection Center (CGMCC), with collection number of CGMCC No.12028. The monoclonal antibody secreted by the cell strain NaN-1 can identify 25 SAs, has better detection sensitivity, enables the IC<50> of sulfadiazine (SD), sulfamerazine (SMR), sulfadimethoxine (SDM) and sulfathiazole (STZ) to be respectively 4.51mu g / L, 1.80mu g / L, 1.98mu g / L and 0.53mu g / L and can be used for multi-residue detection of SAs in food safety.

The invention discloses a composite sulfadiazine-trimethoprim nanoparticle preparation. The particle size of the nanoparticle preparation ranges from 1 to 100 nm. The nanoparticle preparation is prepared from sulfadiazine, trimethoprim, a macromolecule substance and a cosurfactant. The composite preparation is a nanoparticle preparation which is good in stability and high in solubility; the sulfadiazine and the trimethoprim in the preparation have remarkable synergetic effects, and with the combination of the two components, the antibacterial function of the preparation can be greatly improved, in addition, anti-medicine strains can be reduced; the composite nanoparticle preparation has the advantages of safety, high efficiency, wide spectrums, low drug resistance, and the like.

The invention discloses a compound sulfadiazine suspension. The compound sulfadiazine suspension comprises sulfadiazine, trimethoprim, sodium hydroxide, a suspending aid A, a suspending aid B, a surfactant and water for injection. The preparation method comprises steps as follows: sulfadiazine and trimethoprim are ground to 400-700 nm; trimethoprim is added to the suspending aid A; the mixture is dissolved, and a first dissolved solution is obtained; the water for injection is taken and heated to 45 DEG C, sulfadiazine and the suspending aid B are added, and a second dissolved solution is obtained; the rest water for injection is taken and heated to 30 DEG C-50 DEG C, sodium hydroxide is added and dissolved, the first dissolved solution is heated to 60 DEG C-65 DEG C, the second dissolved solution is heated to 40 DEG C-50 DEG C, then the first dissolved solution and the second dissolved solution are mixed, a third dissolved solution and the surfactant are added to a batching container and uniformly stirred, and a fourth dissolved solution is obtained; the prepared fourth dissolved solution is added to a high-speed homogenizer and sheared for 10-20 minutes, and filtrate is sterilized for 30 minutes at the temperature of 100-300 DEG C and under the pressure of 0.1-0.2 Mpa. The absorptivity is improved, the acetylation rate is decreased, and few crystals are formed in urine.

The invention discloses a synthetic method for sulfadiazine. The sulfadiazine is synthesized with sulphaguanidine and malonaldehyde as raw materials. The synthetic method has the advantages of being mild in reaction condition, short in reaction time, high in conversion rate and beneficial to industrial production.