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Sulfadiazine salt high-molecular hydrogel dressing and its preparation method

A technology of salt polymer and sulfadiazine, which is applied in the field of sulfadiazine salt polymer hydrogel dressing and its preparation, can solve the problems of wound skin irritation, difficulty in controlling the dosage, and contamination of clothes, etc. control, easy dressing change, and increased contact time

Inactive Publication Date: 2007-05-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dosage forms have the disadvantages of polluting clothes in use, difficulty in controlling the dosage, difficulty in lasting drug effect and needing cotton gauze and adhesive plaster to fix, causing adverse irritation to the wound skin, etc., which are inconvenient to use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of solution A: Dissolve 0.025g of N,N'-methylenebisacrylamide in 3.5g of acrylic acid at room temperature, then slowly drop 8ml of sodium hydroxide solution (0.22g / ml) into the acrylic acid Until the system pH=6~7, after the reaction is complete, add 5ml of 0.01g / ml chitosan acetic acid aqueous solution (0.006g / ml) that has been dissolved in advance, and stir evenly to obtain solution A;

[0031] (2) Prepare solution B: disperse 0.3 g of silver sulfadiazine in 3 ml of glycerin;

[0032] (3) Prepare solution C: Mix 2.5ml polyvinyl alcohol aqueous solution (0.1g / ml), 2ml potassium persulfate aqueous solution (0.02g / mL), and 1-2ml water until fully dissolved;

[0033] (4) Add solution A into solution B, stir evenly, add solution C and a small amount of cooling agent, stir evenly, pour into a mold, heat at 50° C. to polymerize and cross-link to obtain the acyclovir polymer hydrogel dressing.

[0034] (5) Cover both sides of the dressing with non-woven fabri...

Embodiment 2

[0037] (1) Preparation of solution A: Dissolve 0.03g of N,N'-methylenebisacrylamide in 4.0g of acrylic acid at room temperature, then slowly drop 8ml of sodium hydroxide solution (0.22g / ml) into the acrylic acid Until the system pH=6~7, after the reaction is complete, add 5ml of 0.01g / ml chitosan acetic acid aqueous solution (0.006g / ml) that has been dissolved in advance, and stir evenly to obtain solution A;

[0038] (2) Prepare solution B: disperse 0.3 g of silver sulfadiazine in 3 ml of glycerin;

[0039] (3) Preparation of solution C: Mix 5ml of polyvinyl alcohol aqueous solution (0.1g / ml), 2ml of potassium persulfate aqueous solution (0.02g / mL), and 1-2ml of water until fully dissolved;

[0040] (4) Add solution A into solution B, stir evenly, add solution C and a small amount of cooling agent, stir evenly, pour into a mold, heat at 60° C. to polymerize and cross-link to obtain the acyclovir polymer hydrogel dressing.

[0041] (5) Cover both sides of the dressing with no...

Embodiment 3

[0044] (1) Preparation of solution A: Dissolve 0.05g of N,N'-methylenebisacrylamide in 6g of acrylic acid at room temperature, then slowly drop 20ml of sodium hydroxide solution (0.22g / ml) into the acrylic acid until System pH=6~7, after the reaction is complete, add 10ml of 0.01g / ml chitosan acetic acid aqueous solution (0.006g / ml) that has been dissolved in advance, and stir evenly to obtain solution A;

[0045] (2) Prepare solution B: disperse 0.6g silver sulfadiazine in 6ml glycerin;

[0046] (3) Prepare solution C: mix 8ml polyvinyl alcohol aqueous solution (0.02g / ml), 4mL potassium persulfate aqueous solution (0.02g / mL), and 1-2ml water until fully dissolved;

[0047] (4) Add solution A into solution B, stir evenly, add solution C and a small amount of cooling agent, stir evenly, pour into a mold, heat at 50° C. to polymerize and cross-link to obtain the acyclovir polymer hydrogel dressing.

[0048] (5) Cover both sides of the dressing with non-woven fabric and anti-adh...

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PUM

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Abstract

The invention discloses a making method of macromolecular aquagel dressing of sulfanilamide pyrimidine salt, which comprises the following steps: dissolving N, N'-methylene diacrylamide into acrylic acid completely; dripping sodium hydroxide solution into acrylic acid; adding polyvinyl alcohol solution and chitose acetic acid solution; stirring evenly to obtain solution A; dispersing sulfanilamide pyrimidine salt powder into glycerin to obtain solution B; blending potassium persulfate solution and residual water completely to obtain solution C; dripping solution A in the solution B; stirring evenly; adding solution C; pouring into mould; heating to obtain the product to treat burn.

Description

technical field [0001] The invention relates to a drug dressing, in particular to a sulfadiazine salt polymer hydrogel dressing and a preparation method thereof. Background technique [0002] Sulfadiazine salt (silver, zinc) (SD-Ag) is the drug of choice for clinical treatment of wounds such as burns and scalds over the years. Escherichia coli has a strong inhibitory effect. In recent years, sulfadiazine zinc (SD-Zn) has also been used in the treatment of burns and other wounds. It not only has the effect of preventing infection, but also can accelerate tissue repair and promote Wound healing; in addition, 20% of the zinc in the human body is concentrated on the skin, and zinc is related to immunity and wound healing, so it is necessary to supplement zinc for burn patients. [0003] Chitosan is one of the most abundant natural polymers in the world. It has good biocompatibility and degradability, and has antibacterial, anti-inflammatory, and hemostatic effects. In recent ...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/24A61K31/505
Inventor 刘新星黄玮童真
Owner SOUTH CHINA UNIV OF TECH
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