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Sulfadiazine rapid release tablet and preparation method thereof

A technology for sulfadiazine and immediate-release tablets, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery to achieve the effects of rapid release, simple preparation, and improved reliability and effectiveness

Inactive Publication Date: 2013-06-26
SHANGHAI TIANLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sulfonamides are broad-spectrum antimicrobials, but because many common clinical pathogens are resistant to such drugs, they are only used for infections caused by sensitive bacteria and other sensitive pathogenic microorganisms

Method used

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  • Sulfadiazine rapid release tablet and preparation method thereof
  • Sulfadiazine rapid release tablet and preparation method thereof
  • Sulfadiazine rapid release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023]

[0024]

[0025] Preparation: pulverize the above-mentioned auxiliary materials respectively and pass through a 60 mesh sieve; after fully mixing sulfadiazine and poloxamer 188, sieve and mix with calcium hydrogen phosphate and cross-linked sodium carboxymethyl starch, and prepare granules by dry granulation , including pressing into large pieces, then crushing, sieving through a 14-mesh sieve to granulate, and adding micropowder silica gel for tableting.

Embodiment 2

[0027] prescription:

[0028]

[0029] Preparation: pulverize the above-mentioned auxiliary materials respectively and pass through a 60-mesh sieve; fully mix sulfadiazine and sodium dodecyl sulfonate, sieve and mix with compressible starch and low-substituted hypromellose, and add micropowder silica gel for tableting, That's it.

Embodiment 3

[0031] prescription:

[0032]

[0033] Preparation: pulverize the above-mentioned auxiliary materials respectively and pass through a 60-mesh sieve; fully mix sulfadiazine and sodium alginate, sieve and mix with lactose and cross-linked polyvinylpyrrolidone, and add micropowder silica gel to press into tablets.

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PUM

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Abstract

The invention provides a sulfadiazine rapid release tablet. The sulfadiazine rapid release tablet comprises a sulfadiazine active ingredient as well as one or more of a filler, a disintegrating agent, a binding agent, a lubricating agent, a flow aid, a flavouring agent, a smell reducing agent and a colouring agent and further comprises a release accelerator which can promote release of the active ingredient. The release accelerator can be selected from the following substances: lauryl sodium sulphate, poloxamer, Twain, cetyltriethyl ammonium bromide, sodium laurylsulfate, sodium stearyl sulfonate, polyoxyethylene higher aliphatic alcohol, sucrose ester, sorbitol fatty ester, soybean phospholipil, alginic acid, sodium alga acid and aluminium-magnesium silicate colloid, and usage amount of the release accelerator accounts for 0.1-5% of the total weight of the sulfadiazine rapid release tablet.

Description

technical field [0001] The invention relates to a solid oral preparation for the treatment of cardiovascular diseases, such as myocarditis, cardiomyopathy, ischemic encephalopathy and other diseases, in particular to a rapid-release sulfadiazine tablet, and the invention also relates to a sulfadiazine tablet of the tablet. Preparation. Background technique [0002] Sulfadiazine immediate-release tablets belong to the middle-acting sulfonamides, which are effective against non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella and other intestinal bacteria. Bacteriaceae, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae have antibacterial activity, and also have antimicrobial activity in vitro against Chlamydia trachomatis, Nocardia asteroidis, Plasmodium and Toxoplasma gondii. Sulfonamides are broad-spectrum antibacterial drugs, but because many common clinical path...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/635A61P9/00A61P9/10
Inventor 丁杰
Owner SHANGHAI TIANLONG PHARMA
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