38 results about "Sulfachlorpyridazine" patented technology

The invention relates to soluble powder for preventing and treating coccidiosis of poultry, comprising sulphaquinoxaline sodium, trimethoprim and auxiliary materials. The inventive medicament is mainly used to prevent and treat coccidiosis of poultry, rabbits, lambs etc. The sulphaquinoxaline sodium and trimethoprim have compatibility when used together. The trimethoprim is used as an antisepsis synergist of sulphaquinoxaline sodium when resisting coccidian, thus strengthening medicament effect of sulphaquinoxaline sodium. The sulfachlorpyridazine sodium and trimethoprim have synergetic effect during different growing periods of coccidian, simultaneously kill ova and imagoes, thus effectively treating colibacillosis. The soluble powder has good absorption and relatively high safety when orally taken.

The invention relates to a test strip for rapidly detecting trace sulfachlorpyridazine and a preparation method thereof. According to the test strip, the bottom layer is a support layer, the middle layer is an adsorption layer, and a protection layer is fixed on the adsorption layer; the adsorption layer sequentially comprises an adsorption fibre layer, a gold-labelled antibody fibre layer, a cellulose membrane layer and a water-absorbing material layer from a test end; a detection imprint printed by carrier protein solution coupled with sulfachlorpyridazine, and a control imprint printed by goat anti-mouse IgG antibody solution or rabbit anti-mouse IgG antibody solution or goat anti-rabbit IgG antibody solution are formed on the cellulose membrane layer; a gold-labelled antibody is a colloidal gold-labelled sulfachlorpyridazine antibody. The test strip disclosed by the invention is strong in specificity, high in sensitivity, simple and convenient, intuitive, accurate, wide in application range, low in cost, simple and convenient to operate, capable of meeting the needs of personnel in different levels, wide in market prospect, and easy to popularize and apply.

The invention discloses a method for preparing sulfachlororyridazine sodium, which belongs to the technical field of chemical synthesis. The method comprises the following steps of: performing chlorination reaction of 3,6-dihydroxypyridazine and a chlorinating agent to produce 3,6-dichlorophyridazine; reacting the 3,6-dichlorophyridazine with sulfanilamide and potassium carbonate, adding hot water and activated carbon for decoloring, performing filtration to remove the activated carbon, demixing filtrate, extracting supernatant, adding a diluted hydrochloric acid, adjusting a pH value of the mixed solution to be 4.0 to 5.0, performing the filtration, extracting solid matters and washing it with water to produce sulfachlorpyridazine; and finally reacting the sulfachlorpyridazine with the aqueous solution of sodium hydroxide, and performing cooling, crystallization and filtration to produce the sulfachlororyridazine sodium. The method has the advantage of simplifying a production operation process by directly entering the next condensation reaction after HPLC content measurement without taking the 3,6-dichlorophyridazine out as well as refining and purification, along with low production cost and high practical value.

The invention discloses compound sulfachloropyridazine. The compound sulfachloropyridazine is prepared from sulfachloropyridazine or salt thereof and ormetoprim, wherein the mass ratio of the sulfachloropyridazine or the salt thereof to the ormetoprim ranges from (20 to 1) to (1 to 1); the invention further discloses a preparation method of the compound sulfachloropyridazine; the preparation method comprises the following step: sufficiently mixing the sulfachloropyridazine or the salt thereof and the ormetoprim to prepare the compound sulfachloropyridazine. The compound sulfachloropyridazine has the advantages that the ormetoprim is added into the sulfachloropyridazine or the salt thereof, and the ormetoprim is used for inhibiting bacterial dihydrofolate reductase to interfere the synthesis of tetrahydrofolic acid, so as to inhibit the growth of bacteria; the ormetoprim has a relatively strong self bacterium-inhibiting capability, is combined with the sulfachloropyridazine or the saltthereof to have a stronger antibacterial synergistic effect and has a synergistic effect; the ormetoprim more easily penetrates through a tissue barrier and the compound sulfachloropyridazine more easily enters endometrium to express better medicinal performance.

The invention relates to compound sulfachlorpyridazine sodium powder, and specifically provides compound sulfachlorpyridazine sodium powder used for controlling pasteurella infection of livestock and poultry. 100 parts of the compound sulfachlorpyridazine sodium powder comprise 60 to 65 parts of sulfachlorpyridazine sodium, 2 to 4 parts of indometacin potassium, 10 to 25 parts of a suspending agent, 2 to 4 parts of a corrigent and the balance an acceptable carrier. The ingredients above are mixed and grinded so as to obtain the compound sulfachlorpyridazine sodium powder. The compound sulfachlorpyridazine sodium powder possesses accurate curative effects on pasteurellosis of a plurality of animals, and is suitable for popularization and application in livestock breeding. According to the preparation method, sulfachlorpyridazine sodium and indometacin potassium are used together, besides antisepsis and anti-inflammation effects, indometacin potassium is used as an antibacterial synergist of sulfachlorpyridazine sodium, so that synergistic effect is achieved, and pharmacological function of the main medicine is improved. Absorptivity of the compound sulfachlorpyridazine sodium powder, which can be taken orally, or mixed with feed for use, or dissolved in drinking water for use, is high; drug tolerance is difficult to be caused; the compound sulfachlorpyridazine sodium powder is safe to be used for protection, prevention and therapy in a long term. Palatability, fluidity and suspending water solubility are excellent; clinical administration methods are diverse; and the compound sulfachlorpyridazine sodium powder is convenient for clinical administration.

The invention relates to compound sulfachlorpyridazine sodium powder, and specifically provides a preparation method of compound sulfachlorpyridazine sodium powder used for controlling pasteurella infection of livestock and poultry. 100 parts of the compound sulfachlorpyridazine sodium powder comprise 60 to 65 parts of sulfachlorpyridazine sodium, 2 to 4 parts of indometacin potassium, 10 to 25 parts of a suspending agent, 2 to 4 parts of a corrigent and the balance an acceptable carrier. The ingredients above are mixed and grinded so as to obtain the compound sulfachlorpyridazine sodium powder. The compound sulfachlorpyridazine sodium powder possesses accurate curative effects on pasteurellosis of a plurality of animals, and is suitable for popularization and application in livestock breeding. According to the preparation method, sulfachlorpyridazine sodium and indometacin potassium are used together, besides antisepsis and anti-inflammation effects, indometacin potassium is used as an antibacterial synergist of sulfachlorpyridazine sodium, so that synergistic effect is achieved, and pharmacological function of the main medicine is improved. Absorptivity of the compound sulfachlorpyridazine sodium powder, which can be taken orally, or mixed with feed for use, or dissolved in drinking water for use, is high; drug tolerance is difficult to be caused; the compound sulfachlorpyridazine sodium powder is safe to be used for protection, prevention and therapy in a long term. Palatability, fluidity and suspending water solubility are excellent; clinical administration methods are diverse; and the compound sulfachlorpyridazine sodium powder is convenient for clinical administration.

The invention relates to a synthetic method of long-acting sulfonamide. The synthetic method comprises the following steps: (a) sequentially adding methyl alcohol, caustic soda flakes and sulfachloropyridazine sodium into a reaction kettle, stirring for reaction for 1-15 hours at the pressure of 0.1-1.0 MPa and the temperature of 50-160 DEG C to obtain a first mixed solution, cooling the reaction kettle to a normal temperature, and depressurizing the reaction kettle to normal pressure, wherein the mass ratio of the methyl alcohol to the caustic soda flakes to the sulfachloropyridazine sodium is (1-3): (0.1-0.8): 1; (b) evaporating the first mixed solution to dryness, adding first deionized water for dissolution, adjusting the pH value to be 5.4-6.3 for product crystal precipitation, and carrying out suction filtration to obtain a crude product, wherein the ratio of the methyl alcohol to the first deionized water is (2-3) g: (1.5-2) ml; (c) adding the crude product into a decoloration 3-mouth bottle, adding second deionized water for dissolution, adjusting the pH value to be 12-14, adding activated carbon, stirring for 10-60 minutes at the temperature of 0-100 DEG C, filtering, adjusting the pH of the filtrate to be 5.4-6.3 for product crystal precipitation, carrying out suction filtration, and drying, wherein the ratio of the methyl alcohol to the second deionized water to the activated carbon is (2-3) g: (4-6) ml: (0.05-0.2) g. According to the synthetic method, the yield of the long-acting sulfonamide can be improved, and the cost is reduced.

The invention relates to compound sulfachlorpyridazine sodium powder for preventing and treating pasteurella infection of livestock and poultry. The compound sulfachlorpyridazine sodium powder comprises the following components by weight: 60-65 parts of sulfachloropyridazine sodium, 2-4 parts of indometacin potassium, 10-25 parts of suspending agents, 2-4 parts of flavoring agents and acceptable carriers accounting for parts added to be 100 parts. The compound sulfachlorpyridazine sodium powder has definite effect on pasteurellosis of various animals and is suitable for being popularized and applied to breeding of livestock and poultry. According to the compound sulfachlorpyridazine sodium powder, the sulfachloropyridazine sodium and the indometacin potassium are compatible for use, so that when antibacterial and anti-inflammatory effects are achieved, the indometacin potassium serving as the antibacterial synergist of the sulfachloropyridazine sodium can have an synergistic effect to strengthen the drug effect of the main drug. The compound sulfachlorpyridazine sodium powder can be taken orally or mixed in feeds or drinking water, is good in absorption and safe in usage, does not produce drug resistance easily, can be used for health protection, prevention and treatment for a long time, has good palatability, flowability and suspension water-soluble performance, and is various in clinical dosing mode and convenient to dose.

The invention belongs to the field of antibiotic detection, and relates to an analysis and determination method for four kinds of sulfonamide antibiotics in a water sample, which utilizes negative pressure suction filtration membrane solid-phase extraction technology and adopts metal organic framework material NH 2 ‑MIL‑101 (Fe) membrane solid phase extraction‑high performance liquid chromatography for the determination of four antibiotics, sulfadiazine, sulfamethazine, sulfachloropyridazine and sulfamethoxazole in environmental water samples. The method is simple, fast and sensitive to operate, and has the advantages of low detection limit, accuracy and good reproducibility; at the same time, the raw materials used in the invention are cheap and easy to obtain, the material preparation process is simple, the reaction conditions are mild, the application environment is friendly, and the market prospect is broad.