Compound sulfachlorpyridazine sodium powder and preparation method thereof

The technology of sulfachlordazine sodium and chlordazine sodium powder is applied in the field of compound sulfachlordazine sodium powder and preparation thereof, and can solve the problems of not being able to exert maximum curative effect, reducing animal absorption rate, reducing bioavailability and the like, and achieving The effect of improving bioavailability, improving palatability, and increasing solubility

Inactive Publication Date: 2020-12-29
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It cannot meet the requirements of administration through drinking water, greatly reduces the abs

Method used

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  • Compound sulfachlorpyridazine sodium powder and preparation method thereof

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Effect test

Embodiment 1

[0027] A kind of compound sulfachlordazine sodium powder of the present embodiment, every 100g includes raw materials: 62.5g of sulfachlordazine sodium, 12.5g of trimethoprim, 2g of poloxamer, 15g of beta cyclodextrin, sucrose 8g.

[0028] The method for preparing above-mentioned compound recipe sulfachlorperazine sodium powder is carried out according to the following steps:

[0029] (1) Dry beta-cyclodextrin at 105°C for 8 hours, and control the weight loss on drying within 3.0%;

[0030] (2) Weigh the dried beta-cyclodextrin, dissolve it in an appropriate amount of hot water at 60°C, add 2g of poloxamer, and stir evenly;

[0031] (3) Add the prescribed amount of sulfa synergist, keep the temperature at 60°C, and stir to dissolve;

[0032] (4) After the sulfa synergist is completely dissolved, take the prescribed amount of sulfachlordazine sodium and filler, and stir to dissolve;

[0033] (5) Turn on the machine to preheat the spray tower, set the parameters and spray dry...

Embodiment 2

[0036] A kind of compound sulfachlordazine sodium powder of the present embodiment, every 100g includes raw materials: sulfachlordazine sodium 62.5g, trimethoprim 12.5g, polysorbate 80 2g, beta cyclodextrin 13g, sucrose 10g.

[0037] The method for preparing above-mentioned compound recipe sulfachlorperazine sodium powder is carried out according to the following steps:

[0038] (1) Dry beta-cyclodextrin at 105°C for 12 hours, and control the weight loss on drying within 1.0%;

[0039] (2) Weigh the dried beta-cyclodextrin, dissolve it in an appropriate amount of hot water at 60°C, add 2g of polysorbate 80, and stir evenly;

[0040] (3) Add the prescribed amount of sulfa synergist, keep the temperature at 60°C, and stir to dissolve;

[0041] (4) After the sulfa synergist is completely dissolved, take the prescribed amount of sulfachlordazine sodium and filler, and stir to dissolve;

[0042] (5) Turn on the machine to preheat the spray tower, set the parameters and spray dry...

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Abstract

The invention discloses compound sulfachlorpyridazine sodium powder and a preparation method thereof. The compound sulfachlorpyridazine sodium powder is prepared from the raw materials in parts by weight of 59-65 parts of sulfachlorpyridazine sodium, 11-13 parts of sulfanilamide synergist, 11-26 parts of inclusion compound, 1-2 parts of cosolvent and the balance filler. The compound sulfachlorpyridazine sodium powder is obtained by adopting an inclusion technology and spray drying. The inclusion compound is used after being dried for 8-12 hours, so that the inclusion space of the inclusion compound is increased, trimethoprim can be better included, the bad smell and bitter taste of trimethoprim are covered, the palatability of traditional compound sulfachlorpyridazine sodium powder is improved, the solubility of sulfachlorpyridazine sodium powder is increased, active ingredients are stably released, and the bioavailability is improved.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a compound sulfachlordazine sodium powder and a preparation method thereof. Background technique [0002] The antibacterial spectrum of sulfachlordazine sodium is similar to that of sulfamethoxine, and it is the sulfa drug with the strongest antibacterial activity in vivo and in vitro. It has a wide antibacterial spectrum and a wide range of effects, and has a good inhibitory effect on most Gram-positive and Gram-negative bacteria. Clinically, it is mainly used for infectious diseases of Escherichia coli and Pasteurella in pigs and chickens. It also has a significant effect on coccidia, toxoplasma, leukocytozoa, etc. Bacteria are slow to develop drug resistance to running, maintain for a long time, have low blood drug concentration, and are not easy to produce crystallization urine and hematuria. [0003] With the emergence of antibacterial synergists such as trime...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/69A61K47/26A61K47/10A61K31/635A61K31/505A61P31/04
CPCA61K9/145A61K9/146A61K47/6951A61K31/635A61K31/505A61P31/04
Inventor 熊玲玲
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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