Sulfachlorpyridazine slow-release nano colloidal particle and preparation method thereof

Abstract

The invention relates to a sulfachlorpyridazine slow-release nano colloidal particle. Every 100g of the nano colloidal particle is prepared from the following components by weight: 0.1 to 6.0 g of sulfachlorpyridazine, 5.0 to 15.0 g of butyl lactate, 1.0 to 5.0 g of propylene glycol alginate, 0.1 to 1.0 g of polyethylene glycol 12000, 1.0 to 3.0 g of beeswax, 15.0 to 25.0 g of polyoxyethylene ether (40) hydrogenated castor oil, 2.0 to 8.0 g of propylene glycol monostearate, 2.0 to 10.0 g of polyvinyl alcohol, 4.0 to 20.0 g of boric acid and the balance of sucrose powder. The particle size of the sulfachlorpyridazine sustained-release nano colloidal particle drug ranges from 10 nm to 200 nm, the sustained-release effect is achieved after oral administration, the toxic and side effects of the drug can be remarkably reduced, and meanwhile the drug effect is exerted to the maximum extent. The invention further discloses a preparation method, the process operability is high, the technology is easy to transform, and the market prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, in particular to a sulfachloropyridazine sustained-release nano-colloid and a preparation method thereof. Background technique [0002] Sulfachloropyridazine is a veterinary sulfonamide drug, which is commonly used clinically for the prevention and control of bacterial and parasitic pathogenic infections that are sensitive to sulfonamide drugs, such as Haemophilus paragallium, Streptococcus, Escherichia coli, Pasteurella , Coccidia, Toxoplasma gondii, etc., but the drug also showed major defects and toxic side effects during the use of poultry farming. Can cause severe kidney swelling in chickens. In addition, for the breeder flocks entering the laying period, the function of the cells that secrete calcium in the fallopian tubes will be disordered, the eggshell quality will decrease, the proportion of broken eggs, soft-shelled eggs, deformed eggs, and sharp-preserved eggs wi...

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Problems solved by technology

[0004] The sulfachloropyridazine drug prepared by the existing preparation technology and process is a common mixing and crushing process, so that when the farm solves the problem of nephrotoxicity, the drug and small Baking soda is used together to relieve symptoms by alkalizing urine with baking soda, but the use of baking soda increases the cost of treatment on the one hand, and on the other hand, with the development of intensive and large-scale farming, the use of full-price feed is becoming more and more extensive , the opportunity to use mixing materials is less and less, and for granular full-price feeds, the process of secondary mixing is easy to destroy the original properties of feed particles, and it is difficult for drugs to mix evenly because of the particle gaps.

In addition, the use of baking soda increases the risk of respiratory alkalosis during the hot summer months

For the toxic and side effects of fallopian tubes, breeder farms often adopt the method of "a small amount of multiple doses" at intervals to prevent the blood concentration from rising too fast and exceeding the threshold that the fallopian tubes can bear. However, this method is time-consuming and laborious in actual operation. rarely used clinically

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