182 results about "Aloe emodin" patented technology

A method of inhibiting angiogenesis in a mammal is disclosed, which employs a pharmaceutically acceptable composition containing a selective inhibitor of protein kinase CK2 (also known as casein kinase II) enzymatic activity, such as emodin, aloe-emodin, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and 4,5,6,7-tetrabromobenzotriazole (TBB). Also disclosed is a use of a selective inhibitor of protein kinase CK2 enzymatic activity in the manufacture of a medicament for inhibiting angiogenesis. An in vitro method of screening a potential antiangiogenic agent is also disclosed. A kit for the treatment of a disease by inhibiting angiogenesis is disclosed that contains the pharmaceutically acceptable composition containing a selective inhibitor of protein kinase CK2 enzymatic activity.

The invention relates to a novel method to prepare diacerein which is an active ingredient for synthesizing medicine for knee osteoarthritis. The invention is characterized in that two steps of oxidation are adopted, firstly, the aloe-emodin is oxidated to rhubarb aldehyde and is acetylated for protection, secondly the intermediate product of the rhubarb aldehyde is oxidated, in this way, the final product diacerein can be obtained. The oxidation process of the invention is easy to control with a friendly environment and the quality of the products is greatly improved, thus the invention is suitable for large-scale production.

The present invention relates to rhubarb extract and its composition, the plant rhubarb Rheum palmatum is extracted to obtain emodin, chrysophanol, aloe-emodin and their mixture of two or three kinds, then mixed and prepared into agricultural pesticide for crops.

The invention discloses a method for measuring effective component content in kuhuang injection on line by near-infrared spectroscopy quickly. Effective components in kuhuang injection mainly comprise aloe-emodin, rhein, emodin, chrysophanol, physcion, sophocarpine and matrine so on. Near-infrared absorption spectroscopy collecting kuhuang injection make data of effective component content relate with near-infrared spectroscopy by HPLC method. Calibration model is built by partial least-squares regression method. Quick on-line measurement for effective component in injection can be accomplished. Studying result shows that near-infrared spectroscopy analyzing method can measure effective component in kuhuang injection effectively. The method is provided with simple pretreatment for sample, quick measurement and measuring multiple components at the same time. It can be used in on-line analysis and on-line quality control in tcm manufacture process.

The invention relates to a polyphenol cross-linking agent and application thereof to preparation of an anti-calcification biovalve. The polyphenol cross-linking agent is prepared in a way that polyphenol compound is dissolved in organic solvent, and then, buffer solution is adopted for dilution, wherein the polyphenol compound is selected from one or multiple of procyanidine, curcumin, resveratrol, puerarin, aloin and aloe-emodin. The preparation method for the anti-calcification biovalve comprises the following steps: dipping a bio-based material which completely removes cells into the polyphenol cross-linking agent to be subjected to cross-linking, and fully cleaning after ending; dipping in PBS (polybutylene succinate) solution and / or D-Hanks solution to be subjected to post-processingto obtain the anti-calcification biovalve. The anti-calcification biovalve provided by the invention has better mechanical property and stability, tissue calcification, inflammation and thrombus can be obviously reduced, biotoxicity is lowered, service life is greatly prolonged, and the defects of serious calcification, short service life and the like of biological cardiac valve materials processed with a traditional glutaraldehyde crosslinking method are overcome.

The invention relates to a preparation method for extracting rhubarb total anthraquinone from traditional Chinese medicine material rhubarb. The method adopts a solvent method to extract main active components of the rhubarb total anthraquinone of rhubarb from the traditional Chinese medicine material rhubarb. The main active components of the rhubarb total anthraquinone comprise emodin, chrysophanol, rhein, emodin methyl ether and aloe emodin. The method comprises process methods of crushing of the rhubarb, percolation, precipitating by alkali, refining of precipitate and concentrate, drying and collection of the rhubarb total anthraquinone, and the like.

The invention belongs to the technical field of biopesticides, and particularly relates to a natural-proportion composition of rheum officinale free anthraquinone as well as a formula of a nano emulsion preparation of the composition, a preparation process of the composition and application of the composition for preventing powdery mildew. Monomer emodin, aloe-emodin, chrysophanol, emodin monomethyl ether and rhein in the rheum officinale free anthraquinone composition are extracted from the traditional Chinese medicine rheum officinale and provided with a natural proportion with a fixed range. The rheum officinale free anthraquinone composition and the nano emulsion preparation thereof can be used for preventing the plant powdery mildew. The free anthraquinone in the rheum officinale free anthraquinone nano emulsion disclosed by the invention is from the traditional Chinese medicine rheum officinale, the extracting process is strong in applicability, the raw material obtaining cost is low, the nano emulsion preparation is spontaneously formed, the process is simple, the quality is controllable, the large-scale production is easy, and an excellent prevention effect is shown for the plant powdery mildew.

The invention discloses a ruthenium-anthraquinone conjugate, the preparation process thereof and the application as a photo-dynamic therapy photosensitizer. The general formula of the ruthenium-anthraquinone conjugate of the invention is [Ru(L)2HAIP].(PF6)2, the general formula of the HAIP is 1,8- dihydroxy -9,10- anthraquinoneimidazole [4,5-f][1,10] phenanthroline, the general of the L is bpy or phen. The preparation process for the ruthenium-anthraquinone conjugate comprises the following procedures: 1. the synthesis of the HAIP: 1,8- dihydroxy -9,10- anthraquinone-3-aldehyde is reacted with the phenanthroline5,6-diketone to produce the HAIP; 2. Ru(L)2Cl2 is reacted with HAIP and NH4PF6 to produce the [Ru(L)2HAIP].(PF6)2. The invention takes the aloe-emodin as the raw material and the ruthenium polypyridyl complex has single chemical composition; the synthesis route is simple and the yields are higher; during the experiment, the compound shows the light suppression to the growth of cancer cells.

Belonging to the field of medical technologies, the present invention discloses application of aloe-emodin in preparation of drugs reducing blood lipid and liver lipid. Specifically, blood lipid refers to total cholesterol and low density lipoprotein in serum, and liver lipid refers to total cholesterol in liver. Toxicity tests show that aloe-emodin has no obvious toxic and side effect. Pharmacodynamic tests of aloe-emodin show that aloe-emodin can significantly reduce the total cholesterol and low density lipoprotein in hyperlipidemia animal model serum, and has obvious blood lipid reducing effect. At the same time, aloe-emodin can also significantly reduce the total cholesterol content of a hyperlipidemia animal model liver, and has obvious liver lipid reducing effect. Therefore, the invention puts forward the application of aloe-emodin in reduction of blood lipid and liver lipid, aloe-emodin has the characteristics of significant lipid reducing effect, low toxicity, no irritation, low price, and convenient production, transportation, storage and taking, and can have broad application prospects as a blood lipid and liver lipid reducing drug.

The invention discloses a method for extracting rhubarb total free anthraquinone extract from rhubarb. The content of total anthraquinone in the rhubarb total free anthraquinone extract is 5-100% (w / w), wherein, the content of five components, namely, rheum emodin, rhein, aloe-emodin, chrysophanol and physcion, accounts for 5-100% (w / w) of all content of total anthraquinone. The method includes the following steps: 1. rhubarb extract is added with acid and then heated for hydrolyzing, and hydrochloric acid is the preferred acid. 2. hydrolysate solution is centrifugated, precipitation part is dissolved by ethanol and put on polyamide columns, effluent liquid is removed, ethanol with a certain concentration is used for removing impurities, finally methanol or ethanol is used for eluting, eluate is collected and methanol or ethanol is removed by evaporation to obtain the rhubarb total free anthraquinone extract which essentially contains rheum emodin, rhein, aloe-emodin, chrysophanol and physcion.

The invention relates to a preparation method and an application of aloe emodin azole compounds, belonging to the technical field of chemical synthesis. The aloe emodin azole compounds are representedas the general formulas I-V and have high biological activity and have shown great development value and broad application prospect in the field of bio-organic pharmaceutical chemistry, antimicrobialactivity test in vitro shows that these compounds have certain inhibitory activity on one or more of gram-positive bacteria, gram-negative bacteria and fungi, these compounds can be used to prepare anti-bacterial and / or anti-fungal drugs, thus providing an opportunity to provide more safe, efficient and diversified candidate drugs for clinical antimicrobial therapy, and helping to solve the increasingly serious clinical treatment problems of drug resistance, persistent pathogenic microorganisms and emerging harmful microorganisms. Its preparation material is simple, cheap and easy to obtain,the synthesis route is short, and the application of anti-infection has important significance.

The invention relates to compound beauty-maintaining jerusalem artichoke aloe skin chewable tablets and a preparation method thereof, belonging to the technical field of food processing. The chewable tablets are prepared by the following steps: taking jerusalem artichoke powder, aloe skin powder and rose petal powder as main raw materials, xylitol, mannitol, citric acid and the like as auxiliary materials and magnesium stearate as a lubricant according to a certain mass ratio, grinding, mixing, adding a wetting agent to prepare a soft material, pelleting, drying, granulating, tabletting, sterilizing, packaging and the like. The prepared chewable tablets are rich in various bioactive substances such as aloe-emodin, aloin, flavonoids compounds, active polysaccharides, dietary fiber, rose anthocyanins and jerusalem artichoke fructosan, uniform in color, palatable in sourness and sweetness and convenient to carry, have the aroma of roses and the clean aromas of aloes and jerusalem artichoke, have the effects of promoting digestion, diminishing inflammation, preventing decayed teeth and obesity, calming the nerves, activating blood, relieving hypertension, hyperlipidemia and hyperglycemia, resisting oxidation and ageing and improving immunity after being eaten often, and have remarkable beauty-maintaining health-care effects.

The composite fodder for fowls and livestock contains corn, rice, wheat bran, rice bran, soybean cake, rape seed cake, fish meal, shell powder and salt as well as aloe powder in the amount of 0.2-0.6 wt%. Aloe contains aloin, aloe emodin, aloe polysaccharide, aloe saponin, amino acids, trace elements, etc. and can prevent and treat intestinal heat and parasitic disease of animals. The fodder with aloe has the function of preventing and treating intestinal heat, parasitic disease and other diseases of animals safely.

The invention relates to the field of non-woven fabric, and discloses antibacterial non-woven fabric, and a preparation method and application of the antibacterial non-woven fabric. The antibacterial non-woven fabric has good antibacterial effect on gram positive bacteria, gram negative bacteria and fungi; the preparation method is simple, the cost is low, no harmful substances are generated, and promotion and application are facilitated. The antibacterial non-woven fabric is prepared from polypropylene non-woven fabric, aloe-emodin, glutaraldehyde and polyethylenimine. The invention also discloses the preparation method of the antibacterial non-woven fabric and the application of the antibacterial non-woven fabric in textile industry.

The invention belongs to the technical field of analysis and detection, and discloses a capillary electrophoresis method for simultaneously separating and detecting stilbene glucoside and anthraquinone component in polygonum multiflorum. The method adopts micellar electrokinetic capillary chromatography to analyze and detect polygonum multiflorum extracting solution to obtain the electrophoresis pattern of stilbene glucoside, emodin, aloeemodin, rhein, chrysophanol or physcion; according to a correction curvilinear equation, the concentration of stilbene glucoside, emodin, aloeemodin, rhein, chrysophanol or physcion is calculated. The invention can simultaneously analyze and detect the stilbene glucoside and anthraquinone component in polygonum multiflorum and is simple, quick and efficient; adopted buffer liquid is mainly aqueous solution, does not need a great quantity of organic solvent and has small pollution and environment protection; a small amount of needed solvent and sample is needed, and analysis cost is low.

The invention relates to aloe-emodin (AE) derivatives and their use as anticancer drugs. Saids derivatives show a specific cytotoxicity to tumour cells, also of neuroectodermal origin, to which they may in particular act as aloe-emodin prodrugs. Said pharamcological profile makes them particularly suitable for use in the treatment of neoplasias. Thereofore, pharmaceutical compositions containing said compound may be usefully used in the treatment of neoplasias. It has surprisingly been found that aloe-emodin derivatives in position 3′ (bearing either a positive or negaive charge) exhibit improved sollubility properties and, at the same time, in vitro show cytotoxicity to tumour cells, also of neuroectodermal origin.

The invention relates to a detection method of a medicinal preparation of cortex magnoliae officinalis seven-object soup. According to the method, by optimizing an extraction solvent, extraction time and an extraction method, various chemical components in the medicinal preparation of the cortex magnoliae officinalis seven-object soup are furthest extracted; by optimizing an chromatographic column, a mobile phase and an elution mode of the mobile phase, the various chemical components are better separated; thus a method for a fingerprint spectrum of the medicinal preparation is established, and relatively comprehensive spectrum information is acquired; further, by optimally selecting No.8 peak naringin as an internal reference peak, the facts that in common characteristic peaks, a No.9 peak is neohesperidin, a No.14 peak is ammonium glycyrrhetate, a No.15 peak is aloe-emodin, a No.17 peak is rhein, a No.18 peak is emodin, a No.19 peak is honokiol and a No.21 peak is magnolol are affirmed, and relative retention time of 21 common characteristic peaks is determined; by combining information of multiple chromatography peaks in the fingerprint spectrum, the quality can be comprehensively and systematically detected.

The invention relates to a method for measuring effective ingredients of shenshuanning tablets. The method includes the following steps of 1, preparing reference substance solutions, wherein proper quantities of reference substances including salvianic acid A sodium, salvianolic acid B, hesperidin, berberine hydrochloride, aloe-emodin, rheum emodin, rheinic acid, chrysophanol and emodin monomethyl ether are taken and precisely weighed, and methyl alcohol is added to prepare solutions; 2, preparing reference medicinal material solutions, wherein radix pseudostellariae powder, coptidis rhizome powder, rhizoma pinelliae powder, dried tangerine powder, poria cocos powder, rheum officinale powder, powder of the root of red-rooted salvia, powder of the root of bidentate achyranthes, safflower powder and licorice root powder are taken and precisely weighed, and methyl alcohol is added to prepare solutions; 3, preparing a solution for a test product, wherein sample powder is taken and precisely weighed, and methyl alcohol is added to prepare the solution; 4, carrying out a measuring method, wherein 5 microliters to 15 microliters of the solutions are respectively taken and respectively injected into a liquid chromatograph for testing, and chromatograms are recorded and compared with standard fingerprints.

The aloe vermicelli is produced with starch-rich agricultural product and through soaking and grinding to obtain starch, extruding, washing, sun drying and packing. It features the added aloe juice, which has rice nutritive components and physiological active matter of aloe maintained and contains rich amino acids, vitamines, trace elements, aloin, aloe-emodin and other components. It has the health functions of appetizing, raise sleep quality, promoting secretion of gastric acid, moistening the intestine, resisting senility and preventing tumor.

The invention relates to a preparation method for chemical reference substances of anthraquinone glycoside and stibene glucoside in a rheum officinale medicinal material. The method comprises (1) a step of performing heat reflux extraction after the rheum officinale medicinal material dry root is smashed, and subjecting an extract to concentration under reduced pressure until the extract has no alcohol smell to obtain an extract concentrate; (2) a step of adding the extract concentrate to a macroporous adsorption resin column to perform elution to obtain an eluate of the target components, and subjecting the eluate to concentration under reduced pressure to constant weight to obtain a crude extract of the target components; (3) a step of separating the crude extract by utilization of HSCCC using chloroform-ethyl acetate-methanol-water as a solvent system to individually obtain aloe-emodin-8-O-beta-D-glucoside, emodin-1-O-beta-D-glucoside and emodin-8-O-beta-D-glucoside which are three anthraquinone glycoside compounds, and a stibene glucoside compound resveratrol-4'-O-beta-D-(6''-O-galloyl)-glucoside; (4) a step of purity detection, namely a step of subjecting each of the compounds separated by the HSCCC to purity detection by utilization of HPLC; and (5) a step of structure identification, namely a step of subjecting each of the compounds separated by the HSCCC to <1>H-NMR and <13>C-NMR for identification. The method is simple and fast.

The invention discloses an aloe tobacco substitute product and a manufacturing method thereof, and belongs to the technical field of health products. The aloe tobacco substitute product is prepared by aloe leaves, the aloe leaves are processed through steps of 1) material preparation, 2) pretreatment of the prepared material, 3) a baking process, 4) storage and fermentation and 5) cigarette making, and the aloe is made into cut tobacco or slices and then are processes and produced into cigarettes or cigars. By improving the aloe tobacco substitute product during the processing process, the content of barbaloin or aloe-emodin in the aloe tobacco substitute product can be effectively reduced, when people smoke the aloe tobacco substitute product, the intake of aloe-emodin is controlled, the aloe tobacco substitute product is combined with traditional Chinese medicine, safety of the aloe tobacco substitute product is guaranteed, the health care effect of the aloe tobacco substitute product is improved, under the condition that the physiological need of the smoker is satisfied, tar and harmful components are reduced, and the flavor of aloe tobacco is further improved.

The invention provides a compound preservative for fruits. The preservative for the fruits is composed of an antibacterial preservative solution and a waxy mixed solution. The antibacterial preservative solution is prepared by an antibacterial preservative composition, acetic acid- chitosan, galactomannan, pullulan and other components; the waxy mixed solution is prepared by sodium citrate, sodiumphosphate, cyclodextrin, palm wax, trehalose and other components; the antibacterial preservative composition comprises betaine or betaine hydrochloride, beta-aminobutyric acid, glycerol monocaprylate, gallic acid, thyme essential oil or folium artemisiae argyi essential oil, aloe-emodin and limonene. The preservative for the fruits contains the low content of a waxy component, the waxy componenthas low direct contact performance with the fruits and is easily removed after being attached to the fruit surfaces, and no toxic chemical residue exists.

The invention discloses an analysis method for determining rheum emodin, aloe-emodin, chrysophanol and emodin monomethyl ether in blood plasma at the same time and application of rheum emodin, aloe-emodin, chrysophanol and emodin monomethyl ether in pharmacokinetics, wherein the analysis method for determining rheum emodin, aloe-emodin, chrysophanol and emodin monomethyl ether in the blood plasma at the same time comprises the following steps: (1) preparing a sample; (2) detecting. The analysis method for determining rheum emodin, aloe-emodin, chrysophanol and emodin monomethyl ether in the blood plasma at the same time has good specificity, high precision degree, high accuracy and wide linear range and can be used for in vivo pharmacokinetic determination of Chinese medicinal compositions.

The invention discloses a novel synthesis method for rhein, which comprises the following steps: (1) slowly dripping concentrated sulfuric acid in hydrogen peroxide of -5.0 to 5.0 DEG C while stirring; (2) controlling the temperature of the mixed solution in step (1) to 0 to 30 DEG C, slowly adding aloe-emodin and stirring the mixture, and then preserving the heat for 2.0 to 4.0 hours while stirring; and (3) controlling the temperature of the reaction liquid in step (2) at 10 to 50 DEG C, slowly adding the reaction liquid to the aqueous solution of N,N-dimethyl formamide, stirring the mixed solution, preserving the heat for 2.0 to 2.5 hours, and filtering and washing the mixed solution to obtain a wet rhein product. According to the novel synthesis method, the concentrated sulfuric acid-hydrogen peroxide is taken as an oxidizing agent, so as to avoid the pollution from heavy metallic salt, replace the potassium permanganate, ferric oxide, chromium reagent and hypochlorite in the conventional method, and greatly reduce environmental pollution and the residual of harmful metallic ion in the product; and furthermore, the product prepared by the method is high in yield and purity.

A process for separating aloe-emodin and rhein from rhubarb and purifying them by high-speed counter-current chromatography features that its used solvent is the combination of some of petroleum ether, heptane, hexane, pentane, chloroform, dichloromethane, CCL4, acetonitrile, methanol, ethanol, acetone, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate and water. Its avdantage is high purity up to 98% or more.

The invention discloses a multielement nanometer spray for operating room instrument sterilization and a preparing method thereof. The spray is prepared from propylene glycol, phosphorous acid, nanometer medical stone meal, sodium citrate benzotriazole, fluvastatin, zinc sulfate, iris florentina extract, polygonum orientale extract, aloe-emodin, jasmonic acid, laggera alata extract, 2-phenoxetol, prothioconazole, 4-chloro-3,5-dimethylphenol, iprodione, phosphorous acid, trifloxystrobin, alkyne tert-butyl carbamate, emulgator, defoamer, surfactant, liquid stabilizer, ethanol and deionized water. The spray can achieve antibiosis, lubrication and corrosion resistance, and can be widely applied to operating room instrument sterilization to effectively kill various bacteria and viruses with generating residues and prevent hospital cross infection.

The invention belongs to the field of preparation of organic matters and particularly relates to a preparation process of aloe emodin. The preparation process comprises the following steps: (a) carrying out hydrolysis oxidation on an aloe extract as a raw material, so as to obtain an aloe emodin crude product; and (b) purifying the aloe emodin crude product. The preparation process has the beneficial effects of high product yield and product precision.

The present invention belongs to the field of preparation of the quaternary ammonium salt anticancer drugs, and in particular to aloe-emodin biquaternary ammonium salt with water solubility and anticancer activity and a preparation method thereof. Aloe-emodin quaternary ammonium salt is first obtained, then aloe-emodin quaternary ammonium salt dibenzyl bromide is prepared, and finally aloe-emodin biquaternary ammonium salt is prepared. The preparation method has the advantages of simpleness, little side reaction and high product purity. The obtained biquaternary ammonium salt has better ability to inhibit leukemic cells while maintaining water solubility. The compound with water solubility and anti-cancer activity is expected to be developed into anti-cancer drugs, and has good application prospects.

The invention discloses a method for preparing aloe-emodin of formula (II), comprising the following steps: feeding aloin of formula (I) and an oxidizer into a reaction container, adding water and toluene into the reaction container, stirring the mixture for reaction for 1-8 hours at a temperature between 50 and 110 DEG C, and post-treating the reactants to obtain the aloe-emodin after the reaction is over, wherein the oxidizer is selected from one or a combination of more than one of potassium monopersulfate, K2S2O8, Na2S2O and CaS2O8 in any proportion, and the amount of the substance of the oxidizer is 0.5-10 times of that of the aloin. The method for preparing the aloe-emodin has the advantages of easily obtained raw materials, simple process, little usage of solvent, higher product yield and purity, no iron ion pollution to environment or iron ion residue in the product, and better popularization and application prospects.