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Method for measuring effective ingredients of shenshuanning tablets

A technology for Shenshuining tablets and a detection method, which are applied in the directions of measuring devices, material separation, and analysis of materials, etc., can solve the problems that it is difficult to completely characterize chemical characteristics, and the physical and chemical properties of the chemical constituents of Shenshuining tablets are quite different.

Active Publication Date: 2016-12-07
QINHUANGDAO SHANHAIGUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the large variety of chemical components and the large differences in physical and chemical properties of Shenshuaining Tablets, it is too one-sided to evaluate the quality of the preparation by quantitatively evaluating only a few components in the preparation; it is difficult to fully characterize its chemical characteristics

Method used

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  • Method for measuring effective ingredients of shenshuanning tablets
  • Method for measuring effective ingredients of shenshuanning tablets
  • Method for measuring effective ingredients of shenshuanning tablets

Examples

Experimental program
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Effect test

Embodiment 1

[0092] Step 1: Preparation of reference solution

[0093] Take Danshensu sodium, salvianolic acid B, hesperidin, berberine hydrochloride, aloe-emodin, emodin, rhein, chrysophanol, emodin methyl ether reference substance amount, accurately weighed, add methanol to make each 0.8-1.2ml solution containing danshensu sodium, berberine hydrochloride 45-55μg, salvianolic acid B, hesperidin 80-120μg, aloe-emodin, emodin, chrysophanol, emodin methyl ether 8-12μg , that is.

[0094] Step 2: Preparation of reference medicinal material solution

[0095] Take Pseudostellariae (0.4-0.6g), Coptidis (0.18-0.22g), Pinellia (0.4-0.6g), Chenpi (0.18-0.22g), Poria (0.3-0.5g), Rhubarb (0.7-0.9g) ), Salvia miltiorrhiza (0.8-1.2g), Achyranthes bidentata (0.3-0.5g), safflower (0.18-0.22g), licorice (0.18-0.22g) medicinal powder, accurately weighed, put in a stoppered Erlenmeyer flask, Precisely add 20-30ml of 70-90% methanol, seal it tightly, weigh it, and treat it with ultrasonic for 25-35 minute...

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Abstract

The invention relates to a method for measuring effective ingredients of shenshuanning tablets. The method includes the following steps of 1, preparing reference substance solutions, wherein proper quantities of reference substances including salvianic acid A sodium, salvianolic acid B, hesperidin, berberine hydrochloride, aloe-emodin, rheum emodin, rheinic acid, chrysophanol and emodin monomethyl ether are taken and precisely weighed, and methyl alcohol is added to prepare solutions; 2, preparing reference medicinal material solutions, wherein radix pseudostellariae powder, coptidis rhizome powder, rhizoma pinelliae powder, dried tangerine powder, poria cocos powder, rheum officinale powder, powder of the root of red-rooted salvia, powder of the root of bidentate achyranthes, safflower powder and licorice root powder are taken and precisely weighed, and methyl alcohol is added to prepare solutions; 3, preparing a solution for a test product, wherein sample powder is taken and precisely weighed, and methyl alcohol is added to prepare the solution; 4, carrying out a measuring method, wherein 5 microliters to 15 microliters of the solutions are respectively taken and respectively injected into a liquid chromatograph for testing, and chromatograms are recorded and compared with standard fingerprints.

Description

technical field [0001] The invention relates to a method for detecting traditional Chinese medicines, in particular to a method for determining the active ingredients of Shenshuaining Tablets. Background technique [0002] Shenshuaining Tablet is a Chinese patent medicine already on the market. The formula is: Radix Pseudostellariae, Coptidis Rhizome, Pinellia (made), Tangerine Peel, Poria, Rhubarb, Danshen, Achyranthes bidentata, Safflower, Licorice. [0003] Shenshuaining Tablets have the functions of nourishing qi and invigorating the spleen, promoting blood circulation and removing blood stasis, and dredging the organs to relieve turbidity. It is used for patients with spleen failure, stagnation of blood stasis, low back pain, fatigue, sallow complexion, nausea and vomiting, loss of appetite, dysuria, viscous stool and chronic renal insufficiency caused by various reasons. [0004] Existing detection methods for Shenshuaining Tablets mainly include: identification of rh...

Claims

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Application Information

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IPC IPC(8): G01N30/86G01N30/06
CPCG01N30/06G01N30/8686
Inventor 张旭张仲毅赵相友
Owner QINHUANGDAO SHANHAIGUAN PHARMA CO LTD
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