66 results about "Blood typing" patented technology

The invention relates to a detection method performed on a maternal serum or plasma sample from a pregnant female, which method comprises detecting the presence of a nucleic acid of foetal origin in the sample. The invention enables non-invasive prenatal diagnosis including for example sex determination, blood typing and other genotyping, and detection of pre-eclampsia in the mother.

The invention relates to a detection method performed on a maternal serum or plasma from a pregnant female, which method comprises the presence of a nucleic acid of fetal origin in the sample. The invention enables non-invasive prenatal diagnosis including, for example, sex determination, blood typing and other genotyping, and detection of pre-eclampsia in the mother.

Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.

An apparatus for classifying a liquid patient sample includes at least one sample container having a quantity of a sample that is aggressively acted upon so as to create a flow field. A measurement mechanism includes at least one low angle light emitter aligned with a measurement window of the at least one sample container and a detector oppositely disposed relative to the measurement window. Measurement of the scattered light detects particle characteristics of a moving flow field from the sample to determine, for example, the amount of agglutination of the sample so as to perform blood typing or other classifications without spatial separation.

A centrifuge includes: a plurality of centrifuge discs each disc having an attachment for attaching a container containing a liquid to be centrifuged; a disc driver positioned to engage and rotate the discs; a disc engager / disengager for individually moving each of said discs into and out of contact with the disc driver; and a controller for controlling which discs are engaged or disengaged from the disc driver and the amount of time each disc is centrifuged. In a preferred embodiment, the container is a card for blood typing. In another embodiment, a centrifuge includes: a plurality of centrifuge discs each disc having an attachment for attaching a container containing a liquid to be centrifuged; a plurality of disc drivers positioned to engage and rotate the discs, wherein the rotation of discs are controlled by the plurality of disc drivers; and a controller for controlling which discs are rotated by the plurality of disc drivers and the amount of time the discs are centrifuged by individually controlling each disc driver. In a preferred embodiment, the container is a card for blood typing. An immunohematology instrument includes: a centrifuge which includes a plurality of centrifuge discs each disc having an attachment for attaching a blood typing card containing blood to be centrifuged; a disc driver positioned to engage and rotate the discs; a disc engager / disengager for individually moving each of the discs into and out of contact with the disc driver; and a controller for controlling which discs are engaged or disengaged from the disc driver and the amount of time each disc is centrifuged; an incubator; a metering apparatus; an imaging apparatus; card storage; and reagent storage.

An improved method of collecting identifying information (such as samples and data) from a subject to facilitate later identification of said subject. Identifying information may include biological samples, medical records, photographs and videos, audio recordings, odor characterization (of body or exhalations, for example, characterizing a disease such as diabetes), fingerprints, dental records, and the like. Such a identification kit may be comprised of some combination of the following items: a data recording medium (such as a CD, DVD, flash card, or other memory card, other memory device, or printable data such as a barcode or chart); a first receptacle (such as a plastic bag, vial, or other container) for hair samples; a dentition recorder such as a tooth impression wafer; a second receptacle for a blood sample, which may be part of a blood typing kit or other blood sample collection kit; address information, such as a mailing label which may be supplied already attached to an envelope or other mailing container, or e-mail address, or URL, for sending a copy of collected identifying information to an administrating business; a cheek retractor to facilitate obtaining a dentition record; and a fingerprint kit.

The invention relates to a preparation method of an ABO / RhD blood typing detection reagent card. Six microcolumn gel tubes are arranged on the reagent card and includes a gel tube containing monoclonal anti-A antibodies with IgM property, a gel tube containing monoclonal anti-B antibodies with IgM property, a gel tube containing monoclonal anti-D antibodies with IgM property, two gel tubes which are used for reverse typing and contain a gel suspending medium and a gel tube which is used as a negative control and contains the gel suspending medium. The preparation method comprises the processes of preparing the gel suspending medium, preparing gel, selecting antibodies as well as suspending and packing the gel. The ABO / RhD blood typing detection reagent card prepared by the method has highsensitivity, good specificity and stable quality and can be used for positive typing and reverse typing.

The present invention is directed to a microfluidic biochip based on an agglutination reaction that is frequently used in qualitative typing in the diagnostic medicine field by realizing a specimen inlet, a reagent inlet, a split microchannel, transfer microchannels, a chaos micromixer, a reaction microchamber, a microfilter, a passive microvalve, and an outlet on a plastic microchip. Particularly, the biochip of the present invention is characterized in that portability thereof is superior and a small amount (about 1 μl) of each of a specimen and a reagent is used. In addition, the biochip of the present invention can be cheaply made through conventional photolithography, electroplating, injection molding, and bonding. Therefore, by utilizing the microfluidic biochip for blood typing according to the present invention, a point-of-care diagnosis for performing blood typing based on an agglutination reaction at any place becomes possible.

This invention describes how users can capture digital artifacts from any medical device using their mobile device. Some examples of medical devices included, but are not limited to a medical ID card, Medical ID bracelet, Electronic Medical Records, blood pressure machines, blood glucose, scales, inhalers, INR, prescription bottles and trays, pulse oximeter, etc. Digital artifacts included, but are not limited to a medical ID, basic patient information, patient contact information, emergency contact information, primary care physician information, health insurance information including co-pay and deductibles, prescriptions, office visit summary, appointment cards, Electronic Medical Records (EMR), lab results, blood type, organ / donor status, vital signs, diagnostic data, immunization records, payments and transaction history, pictures, etc

A method for detecting and / or observing particle agglutination comprising: placing a volume of particle suspension on a filter constructed to allow passage of individual particles; placing a volume of solution or suspension containing an agglutination reagent on the particle The location of the suspension; optionally placing the washing solution at the location of the agglutinating reagent; and observing the surface of the location for the presence of particles, which presence indicates that particle agglutination has occurred. Also provided are methods for detecting agglutination in general and hemagglutination, eg, for blood typing and cross-matching in particular. The method consists of continuous vertical addition of whole blood, blood typing reagents, and detergent to the filter. In the case of hemagglutination, colored, preferably red or reddish spots appear after washing. Devices and kits based on the present invention are also claimed which facilitate blood typing and cross matching in a non-laboratory environment without the need for laboratory instruments.

The present invention discloses a system for testing microfluid which is made with a disposable disc. The high sensitivity, high sensing accuracy, and quick response microfluidic disc is demonstrated in the present invention. It is note that easy to test microfluid without traditional detecting method, and then reduce energy and simplify procedure. Furthermore, to additive the microfluidic disc is useful to enhance blood typing, and hence raising the sensitivity by the video recognition of blood agglutination.

The present invention discloses a system for testing microfluid which is made with a disposable disc. The high sensitivity, high sensing accuracy, and quick response microfluidic disc is demonstrated in the present invention. It is note that easy to test microfluid without traditional detecting method, and then reduce energy and simplify procedure. Furthermore, to additive the microfluidic disc is useful to enhance blood typing, and hence raising the sensitivity by the video recognition of blood agglutination.

A method of extracting target nucleic acid and performing PCR augmentation comprises the following steps: adding a cracking liquid, a sample containing target nucleic acid and a reaction liquid which performs PCR augmentation into a PCR reaction tube and evenly mixing; placing in the PCR apparatus for performing PCR augmentation. The invention only needs simple instrument to rapidly and high efficiently extract target nucleic acid from the sample and to synchronously perform real-time fluorescence PCR augmentation detection; the invention has wide detection linear range, accurate quantification for samples of different concentrations, good specificity and good repetitiveness; the invention is extremely simple in operation and suitable for the PCR apparatus of different types; it can be widely applied to the fields of detection of pathogenic microorganism, medicolegal expertise, tissue and blood typing, genetic mutation detection.

The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.

The present invention relates to random access incubator. A centrifuge includes: a plurality of centrifuge discs each disc having an attachment for attaching a container containing a liquid to be centrifuged; a disc driver positioned to engage and rotate the discs; a disc engager / disengager for individually moving each of said discs into and out of contact with the disc driver; and a controller for controlling which discs are engaged or disengaged from the disc driver and the amount of time each disc is centrifuged. In a preferred embodiment, the container is a card for blood typing. In another embodiment, a centrifuge includes: a plurality of centrifuge discs each disc having an attachment for attaching a container containing a liquid to be centrifuged; a plurality of disc drivers positioned to engage and rotate the discs, wherein the rotation of discs are controlled by the plurality of disc drivers; and a controller for controlling which discs are rotated by the plurality of disc drivers and the amount of time the discs are centrifuged by individually controlling each disc driver. An immunohematology instrument includes: said centrifuge; an incubator; a metering apparatus; an imaging apparatus; gel card storage; and reagent storage.

A method and apparatus for characterizing the type of a blood sample and a variety of blood components are provided wherein a transmission spectrum of the sample is collected over a predetermined wavelength range. For blood typing, this spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. Further methods and apparatus are provided for determining the viability of and for cross matching a platelet unit Additional method and apparatus permit analysis of the sample for the presence of a contaminant, Particles can also be counted in the sample, even when present in low concentrations, including white blood cell.

The invention discloses a blood ABD typing rapid comprehensive test card. A card seat (21) of the test card is provided with a plurality of card slots; the plurality of card slots are divided in to a plurality of groups arranged in order; the plurality of card slots are corresponding to a blood group forward typing test region (1), a blood group reverse typing test region (2) and a blood cross-matching test region (3) in sequence; each card slot is provided with a test strip matching the test region thereof; and a card cover is opened with a sampling hole (6) and a flushing hole (7) successively on the positions of each test strip corresponding to the blood group forward typing test region (1), the blood group reverse typing test region (2) and the blood cross-matching test region (3) on the card seat (21). The test card integrates blood group forward typing test, reverse typing test and blood cross-matching test on the same card for simultaneous tests, is short in test time, convenient for carrying, simple in operation, accurate and reliable in results, is suitable for being used in comprehensive tests of primary blood screening and blood group typing, and can also be applied in blood group typing test before transfusion in an emergency military period.

Apparatus and a method for mixing a liquid within a disposable aspirating probe tip so that most of the liquid is forced to move past a transition zone between two different inside diameters to cause rotational mixing. The apparatus and method can be used to provide agglutination of blood, which in turn can be used for blood typing. The probe tip can include a single integral piece, or two separate portions. The transition zone can include a sharp demarcation between inside diameters, or a smooth one.

The invention discloses a microfluidic blood type detection chip. The chip comprises a chip body, and the chip body comprises a positive type blood type identification area which is provided with a first sample injection cavity, a quantitative uniform mixing cavity, a positive type reaction cavity and an air hole; a reverse typing blood type identification area which is provided with a second sample injection cavity, a quantitative separation cavity, a reverse typing reaction cavity and an air hole; a sample is injected into the first sample injection cavity, and the sample and a preset diluent in the first sample injection cavity enter the quantitative uniform mixing cavity through the micro-channel; a sample and a diluent are uniformly mixed in the quantitative uniform mixing cavity and then enter the positive setting reaction cavity to react with a reaction reagent for detection; a sample is injected into the second sample injection cavity and enters the quantitative separation cavity through the micro-channel, the sample is separated in the quantitative separation cavity, and separated plasma enters the reverse typing reaction cavity to react with a reaction reagent for detection. The positive and negative typing blood type identification can be simultaneously carried out, so that the blood type identification result is more accurate.

An improved method of collecting identifying information (such as samples and data) from a subject to facilitate later identification of said subject. Identifying information may include biological samples, medical records, photographs and videos, audio recordings, odor characterization (of body or exhalations, for example, characterizing a disease such as diabetes), fingerprints, dental records, and the like. Such a identification kit may be comprised of some combination of the following items: a data recording medium (such as a CD, DVD, flash card, or other memory card, other memory device, or printable data such as a barcode or chart); a first receptacle (such as a plastic bag, vial, or other container) for hair samples; a dentition recorder such as a tooth impression wafer; a second receptacle for a blood sample, which may be part of a blood typing kit or other blood sample collection kit; address information, such as a mailing label which may be supplied already attached to an envelope or other mailing container, or e-mail address, or URL, for sending a copy of collected identifying information to an administrating business; a cheek retractor to facilitate obtaining a dentition record; and a fingerprint kit.

The invention discloses a blood type testing card punching device. A Y-axis moving device is arranged on the side surface of a clamping tray; a supporting frame is arranged on the Y-axis moving device; a Z-axis moving device is fixed to the upper part of the supporting frame; a puncher is fixed below the supporting frame; the puncher comprises a connecting base and a horizontal punching needle shaft; more than two groups of punching needles are arranged at different angles of the punching needle shaft; the top of the connecting base is connected with the Z-axis moving device; a first supporting plate and a second supporting plate are fixedly connected to the two sides of the bottom of the connecting base; the two ends of the punching needle shaft are mounted on the vertical first supporting plate and the vertical second supporting plate; one end of the punching needle shaft is connected with a driving device; the driving device drives the punching needle shaft to rotate so as to achieve punching needle replacement. The blood type testing card punching device has the beneficial effects as follows: the needles can be changed according to the types of blood type testing cards, so that cross contamination is avoided, the cleaning trouble is avoided, and the working efficiency is improved; multiple groups of blood type testing cards can be punched; the blood type testing card punching device is convenient to use, flexible to move and high in degree of automation.

A blood testing method for use in the detection of a disease, wherein at least one characteristic antibody or complement factor is bound to a subject's red blood cells, comprises providing a microarray wherein a plurality of binding agents therefor are immobilized on a substrate at discrete pre-defined positions; and contacting a blood sample therewith. The presence of bound red blood cells is then detected.

The present invention provides methods and apparatus for detecting the product of a reaction on a particle held at the pressure node of a standing wave. The methods and apparatus are particularly concerned with blood typing and the Coombs method.

A Chaenomeles lagenaria extract having a lectin specific for glycophorin A and method for extracting the same are proposed. The extract is prepared by homogenizing seeds of Chaenomeles lagenaria with a homogenizing agent into a mixture, and the mixture is further processed to produce the extract both effective in inhibiting tumor growth and applicable to a blood typing test.

The invention features systems and methods for the detection of analytes, particularly antigens, complement, and antibodies present in blood. The invention features a system for the detection of antigens, complement, and antibodies on the surface of RBCs and circulating antibodies in the blood.

The present invention discloses a blood typing system, including: a consumable roll including polyester membrane, wherein the polyester membrane has pores permitting individual red blood cells to go through while blocking agglutinated blood complexes; a liquid adding part, adapted to add blood specimen and reagent to the consumable roll, sequentially; and a mechanical part mounted above the consumable roll, adapted to manipulate movement of the liquid adding part. The present invention provides a simple system for blood type testing.

The invention belongs to the field of blood typing testing, and particularly relates to a composition of an antibody diluent for an Rh system typing detection card and the antibody diluent. The composition is composed of mannitol, trehalose and polysucrose in a mass ratio of (1-2) : (3-8) : (5-12). When the composition is used for preparing the antibody diluent, only one antibody diluent needs to be prepared, the composition can be suitable for various related antibodies of the Rh system typing detection card, different antibody diluents do not need to be prepared for different antibodies, and the preparation process of the Rh system typing detection card is simplified; meanwhile, the prepared antibody diluent can remarkably improve the stability of the antibody, prevent the titer of the antibody from being reduced, and avoid the phenomenon of leak detection. Moreover, the antibody diluent is suitable for a microcolumn gel immunodetection technology, sensitivity and specificity can be considered by adopting sephadex of a single model, and the stability of the antibody is effectively protected.

The invention discloses a traditional Chinese medicine composition for preventing ABO maternal-fetal blood group incompatibility. Infant jaundice caused by the ABO maternal-fetal blood group incompatibility mostly belongs to the scope of fetal jaundice and newborn jaundice of traditional Chinese medicine, and the key is preventive treatment during progestation and pregnancy for the infant jaundice. The composition adopts the following traditional Chinese medicines: Japanese angelica tree root bark, orchis, black soybean coat, parmelia tinctourium, thalictrum aquilegiifolium, astragalus bhotanensis, axillary choerospondias bark, dioscorea subcalva prain et bur-kill, dryland willow leaves, hempleaf negundo chastetree leaves and nothapodytes pittosporoides which are decocted by water into decoction. Clinical trials show that a total effective rate of the composition is 98%, and is obviously better than that of 70% of a control group, and the composition has a significant curative effect.