32 results about "Crossmatching blood" patented technology

A method for detecting and / or observing particle agglutination comprising: placing a volume of particle suspension on a filter constructed to allow passage of individual particles; placing a volume of solution or suspension containing an agglutination reagent on the particle The location of the suspension; optionally placing the washing solution at the location of the agglutinating reagent; and observing the surface of the location for the presence of particles, which presence indicates that particle agglutination has occurred. Also provided are methods for detecting agglutination in general and hemagglutination, eg, for blood typing and cross-matching in particular. The method consists of continuous vertical addition of whole blood, blood typing reagents, and detergent to the filter. In the case of hemagglutination, colored, preferably red or reddish spots appear after washing. Devices and kits based on the present invention are also claimed which facilitate blood typing and cross matching in a non-laboratory environment without the need for laboratory instruments.

The invention discloses a fully-automatic blood extraction centrifuging device and an extraction centrifuging method thereof. Before operation such as a blood cross-matching test is conducted in a hospital or a laboratory, currently, medical care personnel or test personnel need to transfer to-be-tested blood in sample tubes into test tubes, then the blood is centrifuged, and therefore operation is cumbersome. The fully-automatic blood extraction centrifuging device comprises a rack, a lifting-type centrifuging mechanism, a blood vessel clamping mechanism, a cutting mechanism, a tool storage mechanism and a tool transport mechanism; the tool storage mechanism comprises a circular tool disc, a tool disc rotating shaft, a tool disc driving motor, a fixed pushing block, a tool storage rack and a first reset spring; and the cutting mechanism comprises a cutting rotating shaft, a rotating motor, a rotary cantilever, a tool box assembly, a tool box driving assembly and a tool box sliding block. The blood in the sample tubes is transferred into the test tubes on a centrifuging rotating disc through instrument automation, blood centrifuging required before blood cross-matching is conducted, and previous complex operation is replaced.

The invention discloses a blood platelet magnetizing and immunolabeling analysis method. The method comprises the following steps: uniformly mixing blood platelets and magnetic beads; magnetizing the blood platelets to obtain suspension; uniformly mixing, incubating and washing the magnetized blood platelets and a detected sample; adding a labeled second antibody and incubating to obtain mixed liquid; applying magnetic force to layer the mixed liquid; determining upper reaction liquid or determining after washing the magnetized blood platelets in the lower layer to obtain a result, namely performing double-phase complementary immune analysis. In the mode, the blood platelet magnetizing and immunolabeling analysis method provided by the invention is used for detecting blood platelet related antigen antibody and cross-matching of blood; the magnetic force is applied so that the magnetized blood platelet is washed without centrifuging; the method is easy and convenient to operate; by a labeled antibody adsorption test for directly determining the upper reaction liquid, the non-specific adsorption in an immunolabeling technology is overcome, the processes of closing and washing are reduced, and the time consumption is short. The method can detect a large number of samples and facilitates automation; the two detection results of the double phases can be verified mutually, so that the accuracy of the detection results is improved.

The invention discloses an automatic cross-matching test method for bloods with unknown groups. Blood group detection and blood cross matching experiments need to be completed by professional testersin a professional laboratory before blood is transfused. A tester adopted in the invention comprises an upper shell, a lower shell, needle releasers, hemostixes, thimble devices, a reagent sucking andadding mechanism, a pedestal, a centrifuging test mechanism, blood matching test tubes, a microscope camera, extracting tube grippers, a test tube gripper for test, a blood receptor test tube gripper, a test tube storage box, an extracting tube storage box, a waste test tube collecting box and a waste extracting tube collecting box. The centrifuging test mechanism comprises an upper disc, a supporting disc, a centrifuging rotating shaft, a positioning rotating shaft, a lifting shaking assembly, a positioning gear and a clutch. The reagent sucking and adding mechanism includes a reagent tray,layered collectors, condensed amine medium reagent stores and a serum guiding tubes. The blood group detection and the blood cross matching test can be automatically completed, and the workload of medical staff in the blood matching process is reduced.

The invention relates to an intelligent blood detection system based on cross blood matching. The system comprises a base, wherein an annular rack is arranged on the outer wall of the base; a motor isarranged, the motor is arranged below the base, an output shaft of the motor is connected with a gear, and the gear is matched with the annular rack; a baffle is vertically arranged on the base, a rubber pad is arranged on the base, a limiting groove is formed in the rubber pad, and a resistance wire is arranged in the limiting groove and used for heating a reagent tube arranged in the limiting groove; a timer is also arranged on the inner wall of the baffle and is used for detecting the reaction time in the reagent tube; and a central control unit which is respectively connected with the resistance wire, the timer and the motor, and can adjust the reaction temperature and the rotating speed in the mixing process according to the reaction time, so reaction efficiency is improved, and detection efficiency is further improved.

The invention discloses a blood code automatic matching method. The method comprises the following steps: before blood matching, performing searching in a blood matching instrument to check whether a same donor has more than two blood components needing cross blood matching at the same time in a stock or not; if so, prompting and displaying the blood components in a list form, and enabling a worker to select blood components for bar code conversion; if not, carrying out barcode conversion on only one blood component of the same donor; and after the experiment is completed, transmitting data to an LIS system, when blood component ISBT-128 standard codes are scanned, searching the converted 15-bit or 12-bit bar codes in a system code comparison table through the blood component codes, and after the corresponding bar codes are searched, acquiring and displaying blood matching results corresponding to the bar codes through the bar codes in a view mode. The method can effectively solve the problem that a blood matching instrument cannot recognize 23-bit bar codes of donors.

The invention discloses a pipelining method and system for treating blood transfusion compatibility detection samples. The pipelining method for treating the blood transfusion compatibility detection samples includes the steps of data input, blood sample treatment, detection matching, cross-matching of blood and sample group placing and storing. According to the step of sample group placing and storing, a sample group is conveyed into sample storage equipment, a direct extraction storage area and a reexamination storage area are sequentially arranged in the sample storage equipment according to the placing time, the sample group is firstly placed in a direct extraction storage area, and the sample group in the direct extraction storage area is transferred to the reexamination storage area after the sample group is stored for days of direct extraction, and the sample group in the reexamination storage area is conveyed into garbage collection equipment after being stored for days of storage. According to the invention, a time-sharing storage mode is utilized, and the sample group is sequentially stored in the direct extraction storage area and the reexamination storage area, so that lots of complicated searching can be avoided, moreover, a target sample group can be conveniently searched, and in addition, secondary blood distribution use of blood braid samples, adverse reaction caused by blood use and accident cause tracing are facilitated.

The invention discloses an ABO blood type positive and negative typing and Rh blood type detection card and a preparation method thereof, and belongs to the technical field of blood type determination. The blood type detection card comprises eight micro-column gel tubes, an A-type erythrocyte reagent and a B-type erythrocyte reagent, the eight micro-column gel tubes comprise a gel tube containing a monoclonal anti-A antibody with IgM property, a gel tube containing a monoclonal anti-B antibody with IgM property, a gel tube containing a monoclonal anti-D antibody with IgM property, a gel tube containing a monoclonal anti-C antibody with IgM property a gel tube containing a monoclonal anti-E antibody with IgM property, two gel tubes for reverse typing, and a blank gel tube. The blood type detection card can simultaneously detect the ABO blood type and the Rh blood type, can provide an accurate and stable detection result, reduces the hemolysis risk probability in the cross-matching process, and has a long service life.

The present invention provides novel methods for the detection of antibodies, in particular, blood group antibodies. The methods of this invention may be applied to pre-transfusion blood compatibility testing for the detection of incompatibility between donor units (comprising donor red blood cells (erythrocytes)) and a recipient.

The invention discloses a test device for cross-matching blood. Existing blood test and blood matching equipment are all large-scale equipment, which will only be used when the amount of experiments is large. The invention includes a freezer body and a test part. A test area is arranged in the freezer body. The upper layer board and the lower layer board arranged at intervals up and down are fixed in the test area. The upper layer board and the lower layer board divide the test area into a blood sample storage chamber, a reagent storage chamber and a test body chamber arranged in sequence from top to bottom. The test part includes a lifting and retrieving mechanism, a blood sample access mechanism, a reagent adding mechanism, a blood collection centrifuge module and a camera. The blood collection centrifugation module includes a sampling mechanical arm, a blood recipient blood sample storage plate, a blood centrifugation mechanism, a needle storage mechanism and an empty test tube storage rack. The invention can automatically detect the blood type of the blood of the blood recipient, and select the blood of the blood donor of the same blood type to perform a cross-matching test, thereby automatically determining a suitable blood donor and sending out a usable blood bag.

The invention discloses a clinical department self-service blood taking method based on an RFID intelligent refrigerator, and belongs to the technical field of blood bank blood transfusion management. The method is applied to a blood transfusion management system, the blood transfusion management system is in communication connection with a refrigerator management system through a network, and the method comprises the steps of blood bag warehousing, inventory forward moving, blood cross matching, blood taking confirmation, blood taking, warehouse-out and the like. A blood bag is moved forwards to the clinical intelligent refrigerator, the blood bag is accurately positioned according to the RFID induction technology, the management work of a blood bank is improved, and the working efficiency is greatly improved. The blood bag which is already moved to the clinical intelligent refrigerator is taken out from the intelligent refrigerator in real time in a self-service mode, the storage state of the blood bag can be better guaranteed, the blood transfusion safety is improved, and meanwhile, monitoring of clinical blood transfusion key links is enhanced, quality and efficiency control in the blood transfusion process is guaranteed, and errors possibly caused in the blood transfusion process are reduced. The clinical blood sampling time and the blood sampling amount are free and convenient, and the blood transfusion management quality level of hospitals is improved.

The invention discloses a blood cross matching method of an unknown blood type. Before blood transfusion, blood type detection and a blood cross matching test should be carried out in a professional lab by a professional tester. A tester adopted in the method comprises an upper shell, a lower shell, a reagent sucking and feeding mechanism, a base, a centrifugation test mechanism, a blood matchingtube, a microscope camera, an extraction tube claw, a test tube claw, a receptor test tube claw, a test tube storage box, an extraction tube storage box, a waste test tube collection box, and a wasteextraction tube collection box. The centrifugation test mechanism comprises an upper disc, a support disc, a centrifugal rotation shaft, a positioning rotation shaft, and an elevating and shaking assembly. The reagent sucking and feeding mechanism comprises a reagent disc, a layered collector, a polybrene medium reagent storing device, a serum conduit, a normal saline storage box, a first serum storage box, and a second serum storage box. The provided tester can automatically finish blood type detection and a blood cross matching test and reduces the workload for the medical workers in blood matching.

The invention relates to the technical field of in-vitro diagnosis, and particularly discloses a blood type serological analysis card comprising a blood type card and an anti-human globulin card and a preparation method of the blood type serological analysis card. According to the blood type serology analysis card, efficient analysis of blood type serology is achieved by means of the mechanism that PMMA microspheres with a certain diameter form a molecular sieve, and meanwhile the blood type serology analysis card is high in filler particle size uniformity, good in temperature resistance effect, small in result interpretation interference, high in human body environment simulation degree, low in external technology dependency and low in price and has good application prospects. And a guarantee is provided for blood type identification, irregular antibody screening and cross blood matching tests.

The invention discloses a special test tube rack for cross-matching examination during transfusion. The special test tube rack comprises a device body, a supporting plate and a device base, wherein the supporting plate is connected to the top of the device body in an embedded mode; the device base is fixedly connected to the bottom of the device body; the supporting plate is fixedly connected to the upper portion of the device base; supporting rods are fixedly connected to the two sides of the top of the device base; a partition plate is fixedly connected to the upper portion of the device body; a containing opening is fixedly connected to the top surface of the supporting plate; the partition plate is fixedly connected to the top surface of the supporting plate;the other side of the partition plate is fixedly connected with the containing opening; a classification label is fixedly connected to the bottom of the containing opening; and anti-skid pads are fixedly connected to the two sides of the lower portion of the classification label. According to the invention, the stability of the special test tube rack is improved through the anti-skid pads; the convenience of the special test tube rack is improved through side edge plates; the practicability of the special test tube rack is improved through a test tube rack mechanism; the convenience of the special test tube rack is improved through the moving mechanism; the adaptability of the special test tube rack is improved through a storage mechanism; and the special test tube rack is suitable for blood matching examination andhas wide development prospects in the future.

The invention discloses an automatic cross-matching tester for bloods with unknown types. Blood group detection and blood cross matching experiments need to be completed by professional testers in a professional laboratory before blood is transfused. The tester comprises an upper shell, a lower shell, needle releasers, hemostixes, thimble devices, a reagent sucking and adding mechanism, a pedestal, a centrifuging test mechanism, blood matching test tubes, a microscope camera, extracting tube grippers, a test tube gripper for test, a blood receptor test tube gripper, a test tube storage box, anextracting tube storage box, a waste test tube collecting box and a waste extracting tube collecting box. The centrifuging test mechanism comprises an upper disc, a supporting disc, a centrifuging rotating shaft, a positioning rotating shaft and a lifting shaking assembly. The reagent sucking and adding mechanism includes a reagent tray, layered collectors, condensed amine medium reagent stores,serum guiding tubes, a normal saline storage box, a first serum storage box and a second serum storage box. The tester can automatically complete blood group detection and the blood cross matching test, and reduces the workload of medical staff in the blood matching process.

The present invention provides novel methods for the detection of antibodies, in particular, blood group antibodies. The methods of this invention may be applied to pre-transfusion blood compatibility testing for the detection of incompatibility between donor units (comprising donor red blood cells (erythrocytes)) and a recipient.

The invention provides a whole blood microfluidic automatic cross-matching system, which includes a blood matching card, an incubation device connected to the sample outlet of the blood matching card, and a detection device connected to the sample outlet of the incubation device. The incubation device includes the first The first mixed incubation area and the second mixed incubation area, the blood matching card includes the diluent quantitative distribution system, the blood supply quantitative distribution system and the blood receiving quantitative distribution system, the sample outlet of the serum quantitative distribution system in the blood supply quantitative distribution system and the blood receiving quantitative distribution The sample outlets of the red blood cell quantitative area in the system are all connected with the first mixed incubation area, the sample outlets of the red blood cell quantitative area in the blood supply quantitative distribution system and the sample outlets of the serum quantitative area in the blood receiving quantitative distribution system are connected with the first mixed incubation area. The two mixing incubation areas are connected. The invention realizes the automatic separation, quantification, mixing and detection process of serum and red blood cells. It is easy to operate and realizes the integration and automation of cross-matching blood detection. At the same time, the invention also provides a whole blood microflow Control the blood matching method of the automatic cross matching system.

The invention discloses a blood cross matching method suitable for a known blood type. Before blood transfusion, blood type detection and a blood cross matching test should be carried out in a professional lab by a professional tester. A tester adopted in the method comprises an upper shell, a lower shell, a reagent sucking and feeding mechanism, a base, a centrifugation test mechanism, a test tube, a microscope camera, an extraction tube claw, a test tube claw, a blood receptor test tube claw, a blood donor test tube claw, a test tube storage box, an extraction tube storage box, a waste testtube collection box, and a waste extraction tube collection box. The centrifugation test mechanism comprises an upper disc, a support disc, a centrifugal rotation shaft, a positioning rotation shaft,and an elevating and shaking assembly. The reagent sucking and feeding mechanism comprises a reagent disc, a layered collector, a polybrene medium reagent storing device, a serum conduit, a normal saline storage box, a first serum storage box, and a second serum storage box. The provided tester can automatically finish blood type detection and a blood cross matching test and reduces the workload for the medical workers in blood matching.

The invention discloses a cross matching blood instrument. Before blood transfusion, professional testers are required to complete blood type testing and cross-matching experiments in professional laboratories. The invention includes a support frame, a reagent suction and adding mechanism, a first serum storage box, a second serum storage box, a physiological saline storage box, a low ion medium storage box, a polybrene solution storage box and a suspension storage box. The reagent suction and adding mechanism includes a reagent plate, a layered collector, a layered extraction tube, a polybrene medium reagent adding tube, and a serum adding tube. The bottom surface of the reagent tray is provided with six installation holes uniformly distributed along the circumference of the reagent tray axis; the six installation holes are all blind holes, and the bottom is fixed with permanent magnetic steel. The tops of the polybrene medium reagent addition tubes, the three layered collectors and the two serum addition tubes are all embedded with adsorption blocks. The invention can assist medical staff to complete blood type detection and cross-matching test, greatly simplifying the workload of medical staff during the blood matching process.

The invention discloses a blood transfusion medical record quality evaluation model. The model is the following mathematical model: F=0.1111*related examination score before blood transfusion+0.0443*applicant physician title score+0.0438*application variety / dose score+0.0456*medical record home page score+0.1456*blood transfusion agreement book score+0.1001*blood transfusion course record score+0.0344*blood transfusion application form score+0.1032*intraoperative blood transfusion record score+0.0591*blood transfusion indication / destination score+0.1179*blood transfusion curative effect evaluation score+0.0677*blood transfusion adverse reaction score+0.0342*blood collection time-to-blood transfusion time score +0.0314*cross blood matching form score+0.0212*blood bag recovery score+0.0402 *blood transfusion starting time-to-ending time score, wherein the highest score of each index is 100, the filling correctness is 100, and the filling error or missing is 0; if F is less than 60, the medical record is unqualified; if F is more than or equal to 60 and less than 80, the medical record is qualified; if F is more than or equal to 80 and less than or equal to 99, the medical record is good; and if F is equal to 100, the the medical record is excellent. The model can be used for clinical blood transfusion management and blood transfusion safety early warning.

The invention discloses a full-automatic blood matching equipment for a blood transfusion department, which is characterized by comprising a conveying unit, a blood type detection unit, a cross blood matching unit, a first storage refrigerator, a second storage refrigerator and a central control unit, and the central control unit is used for sending a blood testing process and recording blood testing information; the conveying unit is used for conveying the blood sample of the patient and the blood sample of the blood supplier according to the blood measuring process; the blood type detection unit is used for performing ABO blood type test and Rh typing test according to a blood testing process; the cross blood matching unit is used for performing cross blood matching operation on the blood of the patient and the blood of the blood donor according to the blood measuring process; the first storage refrigerator is used for temporarily storing blood samples in the blood matching process; and the second storage refrigerator is used for transferring the blood samples in the first storage refrigerator into the second storage refrigerator, and then waiting for treatment, the full-automatic blood matching equipment can achieve full-automatic blood matching and blood taking operation, the workload of workers is reduced, and the working accuracy is improved.

The invention discloses an automatic cross-matching testing method suitable for known blood types. Before the blood transfusion, a professional examiner needs to finish a cross-matching test in a specialized laboratory. A tester comprises an upper-part shell, a lower-part shell, a needle ejection device, a hemostix, a needle ejector, a reagent absorbing and adding mechanism, a base, a centrifugaltest mechanism, a blood matching test tube, a microscope camera, an extraction pipe hand claw, a test tube hand claw for the test, a test tube hand claw for a blood receptor, a test tube storage box,an extraction tube storage box, a waste test tube collection box and a waste extraction tube collection box, wherein the centrifugal test mechanism comprises an upper disc, a support disc, a centrifugal rotating shaft, a positioning rotating shaft and a lifting shaking assembly; and the reagent absorbing and adding mechanism comprises a reagent disc, a layering collector, a condensed amine mediumreagent storage, a serum guiding pipe, a normal saline storage box, a first serum storage box and a second serum storage box. According to the method, the blood type detection and cross-matching testcan be automatically finished, and the workload of medical workers in the blood matching process is simplified.

The invention relates to a high-accuracy blood type diagnosing reagent by blood type serological immune reaction, specially a blood type diagnosing reagent of Rh, Kidd and so on and cross-mixed blood as well as preparing method. The diagnosing reagent includes pawpaw proteinase powder and enzyme inhibitor, pawpaw proteinase diluted solution and enzyme inhibitor diluted solution, and the preparing method: firstly cultivate streptomycin by activated culture medium, then enlarge culture, and finally make industrialized production in fermentation cylinder, and then obtain the finished product through inactivation, purification, condensation and drying. Compared with other medium reagents, the diagnosing agent has characters of higher detecting sensitivity, accurate and reliable identification result, simple method, etc, applied in vitro blood type serological diagnosis tests such as antibody screening test, antibody identification test, antibody effect titration test, transfusion compatibility test, and sensitive blood type identification test.

The invention provides a venous transfusion closed-loop system based on a mobile information platform. A hospital information system, a laboratory information system, a blood bank system and an electronic medical record system are taken as bases; a venous transfusion closed-loop management system is formed on the mobile information platform; medical advice information is automatically read througha wireless WLAN technology, intelligent checking and identity recognition are conducted, and blood sampling and blood transfusion work is completed. The venous transfusion closed-loop system comprises the following procedures: determination of blood types and cross-matching of blood, blood receiving, blood transfusion, automatic generation of blood transfusion records, blood transfusion quality data analysis and monitoring and the like. According to the invention, blood transfusion quality can be improved, blood transfusion safety is guaranteed, and applicability of the blood transfusion system is improved.

The invention provides a safe cross blood matching card and a blood matching method. The blood matching card comprises a blood receptor plasma containing hole, a blood receptor erythrocyte diluent containing hole, a blood donor plasma containing hole, a blood donor erythrocyte diluent containing hole, a main side cross reaction hole and a secondary side cross reaction hole which are sequentially arranged. Hole number identifiers are arranged below the reaction holes; and information identification areas of blood receptor and blood donors are set. In addition, the blood matching method comprises the following steps: respectively putting blood plasma of a blood receptor and blood plasma of a blood donor into corresponding blood plasma containing holes; putting overstocking erythrocytes of the blood receptor and the blood donor respectively in the corresponding containing holes to prepare erythrocyte suspensions; carrying out sampling on the blood receptor plasma containing hole and the blood donor erythrocyte diluent containing hole and adding the sampled products into the main side cross reaction hole; and carrying out sampling on the blood donor plasma containing hole and the bloodreceptor erythrocyte diluent containing hole and adding the sampled products into the secondary side cross reaction hole to complete cross blood matching. Therefore, Pollution of diluent and waste ofresources are avoided; cross contamination is avoided in a unique person-card-correspondence manner; and the safety of clinical blood transfusion is guaranteed.

The invention discloses a blood cross matching tester of an unknown blood type. Before blood transfusion, blood type detection and a blood cross matching test should be carried out in a professional lab by a professional tester. The tester comprises an upper shell, a lower shell, a reagent sucking and feeding mechanism, a base, a centrifugation test mechanism, a blood matching tube, a microscope camera, an extraction tube claw, a test tube claw, a receptor test tube claw, a test tube storage box, an extraction tube storage box, a waste test tube collection box, and a waste extraction tube collection box. The centrifugation test mechanism comprises an upper disc, a support disc, a centrifugal rotation shaft, a positioning rotation shaft, and an elevating and shaking assembly. The reagent sucking and feeding mechanism comprises a reagent disc, a layered collector, a polybrene medium reagent storing device, a serum conduit, a normal saline storage box, a first serum storage box, and a second serum storage box. The provided tester can automatically finish blood type detection and a blood cross matching test and reduces the workload for the medical workers in blood matching.

The invention discloses a blood cross matching method of an unknown blood type. Before blood transfusion, blood type detection and a blood cross matching test should be carried out in a professional lab by a professional tester. A tester adopted in the method comprises an upper shell, a lower shell, a reagent sucking and feeding mechanism, a base, a centrifugation test mechanism, a blood matchingtube, a microscope camera, an extraction tube claw, a test tube claw, a receptor test tube claw, a test tube storage box, an extraction tube storage box, a waste test tube collection box, and a wasteextraction tube collection box. The centrifugation test mechanism comprises an upper disc, a support disc, a centrifugal rotation shaft, a positioning rotation shaft, and an elevating and shaking assembly. The reagent sucking and feeding mechanism comprises a reagent disc, a layered collector, a polybrene medium reagent storing device, a serum conduit, a normal saline storage box, a first serum storage box, and a second serum storage box. The provided tester can automatically finish blood type detection and a blood cross matching test and reduces the workload for the medical workers in blood matching.

The present invention relates to an intelligent blood detection system based on cross-matching blood. The system includes a base, an annular rack is set on the outer wall of the base; a motor is set under the base, and the The output shaft of the motor is connected with a gear, and the gear is matched with the ring rack; the baffle, the baffle is vertically arranged on the base, and a rubber pad is arranged on the base, and the A limiting groove is arranged on the rubber pad, and a resistance wire is arranged in the limiting groove to heat the reagent tubes arranged in the limiting groove; a timer is also arranged on the inner wall of the baffle plate for To detect the reaction time in the reagent tube; the central control unit is respectively connected with the resistance wire, the timer and the motor, and can adjust the reaction temperature and the rotating speed in the mixing process according to the reaction time to improve the reaction efficiency, and then Improve detection efficiency.