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1156results about "Blood transfusion" patented technology
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Post-partum mammalian placenta, its use and placental stem cells therefrom
InactiveUS20030032179A1Enhance exsanguinationEnhance sterile conditionSenses disorderAntipyreticAnticoagulant AgentEmbryo
The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
Owner:CELULARITY INC
Method of collecting placental stem cells
InactiveUS20020123141A1Increase concentrationImprove the environmentSenses disorderAntipyreticCord blood stem cellEmbryo
A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom.
Owner:CELULARITY INC
Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
Owner:CELULARITY INC
Post-partum mammalian placenta, its use and placental stem cells therefrom
The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
Owner:CELULARITY INC
Device for treating a medical liquid
ActiveUS7648627B2Maximum flexibilityFast and simple exchangeabilityOther blood circulation devicesHaemofiltrationEngineeringActuator
An apparatus for the treatment of a medical liquid has a liquid treatment machine and a cassette that is insertable in the machine. The cassette has a rigid base body with fitted chambers and passages and a foil that covers the chambers and passages. Actuators and sensors are arranged in the liquid treatment machine for the operation of the apparatus with the inserted cassette such that cassettes are insertable in different integration shapes.
Owner:FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
Bezel assembly for pneumatic control
ActiveUS20050095154A1Reducing pump strokeReducing the pump strokeFlow mixersOther blood circulation devicesPositive pressureEngineering
A bezel and bezel assembly in which the bezel is a rigid block with a plurality of cavities. A depression in the block has ribs extending up therefrom to form an elevated contour. The depression includes at least one cavity therein for the application of air pressure into the depression and over the elevated contour. A gasket fits over the bezel so that positive pressure applied through the at least one cavity in the depression forces a gasket membrane to expand away from the pumping side and negative pressure applied through the at least one cavity in the depression pulls the gasket membrane against the elevated contour of the ribs. The bezel may include solvent bondable tubing connections for making pneumatic connections to the bezel.
Owner:DEKA PROD LLP
Medical Fluid Cassettes and Related Systems
InactiveUS20100133153A1Maximum flexibilityFast and simple exchangeabilityOther blood circulation devicesHaemofiltrationBiomedical engineering
The invention relates to an apparatus for the treatment of a medical liquid comprising a liquid treatment machine and a cassette insertable therein substantially made of a rigid base body of the cassette with fitted chambers and passages and a foil covering them.
Owner:FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
Blood separation systems and methods using a multiple function pump station to perform different on-line processing tasks
InactiveUS7041076B1Straightforward and accurate control functionReduce complexityOther blood circulation devicesRotary centrifugesBlood componentWhite blood cell
A multiple function pump station performs different on-line processing tasks. The pump station can be operated in one mode to draw blood from a donor can, in another mode, be operated to return blood to the donor. The pump station used to draw blood from a donor can also be used to perform subsequent blood processing tasks, such as mixing processing or additive fluids with the blood, or transfering a harvested blood component to a storage container, or finishing the processing of a harvested blood component, e.g., by passage through a filter to remove leukocytes.
Owner:FENWAL
Plasma concentrator device
Owner:HANUMAN +1
Blood component separator disk
InactiveUS7077273B2Improve processing efficiencyControl flowOther blood circulation devicesDispersed particle separationBlood component separatorRed blood cell
A separator disk (4) for use in centrifugal separation of components is designed to automatically position itself during separation at the interface between the supernatant and the remaining components. Preferably the interface is between plasma and red blood cells.
Owner:HARVEST TECH
Methods and apparatus for isolating platelets from blood
InactiveUS20050186120A1Simple and fast preparationIncrease productionMedical devicesLaboratory glasswaresMedicineRed blood cell
A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
Owner:DORIAN RANDEL +2
Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
Owner:CELULARITY INC
Methods and apparatus for isolating platelets from blood
InactiveUS20050196874A1Simple and fast preparationIncrease productionSurgeryVaccination/ovulation diagnosticsMedicineRed blood cell
A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
Owner:HANUMAN
Predonation blood sampling apparatus
InactiveUS7087047B2Simple and inexpensiveImproved apparatusSurgeryMedical devicesBlood Collection TubeMedicine
This invention discloses a donor blood donation and sampling system including a donor needle adapted for drawing blood from a body, a blood collection bag coupled to a blood collection conduit which is coupled to the donor needle, a blood sampling conduit also coupled to the donor needle, and a sampling tube assembly arranged for selectable fluid engagement with the blood sampling conduit and for selectable clamping engagement with at least said blood collection conduit. A donor blood donation and sampling method is also disclosed.
Owner:TEVA MEDICAL LTD
System and method for processing bone marrow
A system for collecting and processing donated bone marrow comprises a closed and / or sealable collection container and a closed and / or sealable satellite container. The system may also include at least one porous medium interposed between the collection container and the satellite container. The porous medium is a size gradient depletion media. The system may also include at least one third container in fluid communication with the collection container. The system may also include at least one manifold interposed in the fluid flow path between the collection container and the third container.
Owner:BIOACCESS
Device and method for separation
InactiveUS20040069717A1Raise the possibilityHigh particle separationOther blood circulation devicesHaemofiltrationElectricityEngineering
The present invention provides a device and a method for separating particles from fluids using ultrasound, laminar flow, and stationary wave effects comprisinga micro-technology channel system with an integrated branching point or branching fork, and a single ultrasound source. One of the characteristics of the invention is that the single ultrasound source, which generates the standing waves, excites the complete structure including the channel system. No special reflectors or the like are needed. Extremely thin dividers can separate the flow, thereby enhancing the effectiveness of the device. The device could be manufactured in silicon and the ultrasound energy could preferably be delivered by a piezoelectric element.
Owner:ERYSAVE
System and method for pumping fluid using a pump cassette
A system and method for pumping fluid using a pump cassette. The system includes a control assembly for operating the pump cassette. A force assembly having a movable member is capable of applying force to the pump cassette to press the pump cassette against the control assembly. The movable member may be an expandable member, such as a bladder.
Owner:DEKA PROD LLP
Centrifuge chamber for a cell separator having a spiral separation chamber
InactiveUS6277060B1Increase valueEasy to ventWithdrawing sample devicesDispersed particle separationEngineeringCell separation
A centrifuge chamber of a cell separator having a separation channel with an inlet to introduce the cell suspension and at least one outlet to withdraw a fraction of the cell suspension is described. The cell suspension can be blood. The separation channel is shaped like a spiral extending from the radially outer end of the channel to the radially inner end of the channel, with a progressive slope. The centrifuge chamber allows a uniform, contaminant free separation of the cell suspension into its components.
Owner:FRESENIUS AG
Interface device and method for interfacing instruments to vascular access simulation systems
InactiveUS7308831B2Improve realismSimulate the realCosmonautic condition simulationsData processing applicationsControl signalSkin traction
An interface device and method for interfacing instruments to a vascular access simulation system serve to interface peripherals in the form of mock or actual medical instruments to the simulation system to enable simulation of medical procedures. The interface device includes a catheter unit assembly for receiving a catheter needle assembly, and a skin traction mechanism to simulate placing skin in traction or manipulating other anatomical sites for performing a medical procedure. The catheter needle assembly and skin traction mechanism are manipulated by a user during a medical procedure. The catheter unit assembly includes a base, a housing, a bearing assembly and a shaft that receives the catheter needle assembly. The bearing assembly enables translation of the catheter needle assembly, and includes bearings that enable the shaft to translate in accordance with manipulation of the catheter needle assembly. The shaft typically includes an encoder to measure translational motion of a needle of the catheter needle assembly, while the interface device further includes encoders to measure manipulation of the catheter needle assembly in various degrees of freedom (e.g., translation, pitch and yaw) and the skin traction mechanism. Alternatively, the shaft may include an additional encoder to measure translational motion of an instrument inserted through the catheter needle assembly. The simulation system receives measurements from the interface device encoders and updates the simulation and display, while providing control signals to the force feedback device to enable application of force feedback to the catheter needle assembly.
Owner:IMMERSION MEDICAL
Automated system and method for processing biological fluid
InactiveUS6106727AEasy to drainImprove flow characteristicsOther blood circulation devicesHaemofiltrationAutomatic controlPorous medium
An automated system for processing biological fluid includes a pressure differential generator, a biological fluid processing assembly, and an automated control arrangement coupled to at least one of the pressure differential generator and the biological fluid processing assembly. The automated system may include a porous medium, such as a red cell barrier medium, a leukocyte depletion medium, or a combination red cell barrier / leukocyte depletion medium. The automated system may also include a sensor producing a signal reflecting a parameter of fluid flow.
Owner:PALL CORP
Rapid infusion system
InactiveUS6942637B2Rich varietyEasy to installFlexible member pumpsPharmaceutical delivery mechanismPump chamberRapid infusion
A rapid infusion system for the intravenous delivery of fluids at standard and rapid flow rates. The system includes a pump assembly, a drive assembly to power the pump, and a fluid containment system that keeps the infused fluid out of direct contact with the pump assembly and that is preferably disposable and removable. In one embodiment the drive assembly includes a differential drive that interacts with more than one motor. In one embodiment, the pump assembly includes a roller pump and the pump chamber is a collapsible, preformed tube that is preferably attached to a pump cartridge frame. Optionally, the system includes a self-leveling drip chamber and the fluid containment system is disposable and includes a pump cartridge containing the drip chamber and the pump chamber, I.V. tubing, outlet infusion tubing, and a heater cartridge.
Owner:SMISSON CARTLEDGE BIOMEDICAL
Chemiluminescently illuminated suction appliances
This invention relates to chemiluminescent suction devices and methods for using the devices. The devices may be useful as medical, industrial, and consumer products. They may be disposable and may employ an integrated or attachable chemiluminescent source. In some variations, the device may include a supporting structure or body that is at least partially translucent or transparent for transmitting chemiluminescent illumination.
Owner:SIMON JAMES S +1
Tissue matrices comprising placental stem cells
Owner:CELULARITY INC
Medical material handling systems
InactiveUS20050154368A1Inhibition releaseAvoid treatmentInfusion syringesSurgeryFluid couplingAutologous blood
Disclosed herein is a system for the collection, treatment and delivery of an autologous blood sample, comprising a first syringe having a first body portion. A first sample transfer portion has a first syringe inlet for drawing an untreated blood sample from a patient and a first syringe outlet for dispensing the untreated blood sample. A blood sample treatment chamber having a chamber inlet, the first syringe outlet being operable to establish a dedicated first fluid coupling with the chamber inlet to dispense the untreated blood sample to the blood sample treatment chamber. The blood sample treatment chamber having a chamber outlet for dispensing a treated blood sample following treatment. The second syringe has a second body portion and a second sample transfer portion, the second sample transfer portion having a passage with a first access location which is operable to form a dedicated second fluid coupling with the chamber outlet. The second body portion has a second syringe outlet, the passage having a second access location for fluid communication with the second syringe outlet, releasable lock means for forming a locked third fluid coupling between the second access location and the second syringe outlet. The lock means is operable in response to a release signal to release the third fluid coupling, the second syringe outlet being operable when released from the third fluid coupling to form a fourth fluid coupling with a blood sample delivery unit.
Owner:VASOGEN IRELAND LTD
Freezing and thawing bag, mold, apparatus and method
InactiveUS6146124AHigh strengthImprove integrityLighting and heating apparatusConfectioneryFreeze and thawCryopreservation
A mold is disclosed for forming a freezable and thawable bag of uniform thickness, especially useful for cryopreservation of thermolabile substances. The mold features one or more recessed planar surfaces, including radiused peripheral walls about the recesses, a planar top surface, and means for conforming a blank sheet to the mold. Two mold halves combine to form a completed bag. The mold halves may be complimentary.
Owner:CESCA THERAPEUTICS
Pump cassette bank
A plurality of pump cassettes are connected through distribution tubing to a single inlet tube such that the inlet tube is shared by the pump cassettes through the distribution tubing. The plurality of pump cassettes may be symmetrically attached to the distribution tubing. A four-port coupling may be inserted in the distribution tubing for making connection to the inlet tube and a middle one of the pump cassettes when the number of cassettes is an odd number.
Owner:DEKA PROD LLP
Extracorporeal blood processing information management system
ActiveUS7072769B2Simplified storage and controlEase and optimize and operationMechanical/radiation/invasive therapiesOther blood circulation devicesBlood componentCollection system
A blood component collection system with manipulation and optimization capabilities. In one embodiment, process parameters are derived from an input / configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.
Owner:TERUMO BCT
Medical treatment control system
A device for controlling the collection and delivery of materials to a patient, the device has a dispenser-engaging portion, the dispenser-engaging portion being operable in a release position to receive a materials dispenser when the dispenser is in a materials-containing configuration, the dispenser-engaging portion being operable in a lock condition for locking the dispenser therewith, and access control means for controlling the release and lock positions according to a material transaction condition.
Owner:VASOGEN IRELAND LTD
Apparatus and methods for monitoring transfusion of blood
ActiveUS20050184153A1Reduce the amount requiredAccurate identificationTicket-issuing apparatusBallastwaySurgeryHematological test
Owner:NEOTERIC TECH ULC +1
Single-use manifold for automated, aseptic transfer of soulutions in bioprocessing applications
InactiveUS7052603B2Reduce expenditure of resourceReduce time expenditureIon-exchanger regenerationUltrafiltrationPinch valveQuality assurance
Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These manifolds interact with at least one remotely controlled pinch valve which engages only the outside surface of the manifold tubing. Such manifold and pinch valve systems can be used in conjunction with a peristaltic type of pump, which, together with the remotely operated pinch valve, can be operated by a controller which provides automated and accurate delivery of biotechnology fluid in an aseptic environment while avoiding or reducing cleaning and quality assurance procedures.
Owner:PARKER INTANGIBLES LLC
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