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Detection method of medicinal preparation of cortex magnoliae officinalis seven-object soup

A technology of pharmaceutical preparations and detection methods, applied in the field of detection of pharmaceutical preparations, can solve the problems of unstable types and contents, inability to systematically and comprehensively reflect the internal quality of Houpu Qiwutang granules, etc.

Active Publication Date: 2017-12-26
TONG REN TANG TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the quality of Chinese medicinal materials is affected by many aspects such as the place of origin, climate, season, etc., the type and content of the ingredients contained are often unstable, which leads to a certain one-sidedness in only testing the content of a single ingredient.
Therefore, none of the above methods can systematically and comprehensively reflect the intrinsic quality of Houpu Qiwutang granules.

Method used

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  • Detection method of medicinal preparation of cortex magnoliae officinalis seven-object soup
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  • Detection method of medicinal preparation of cortex magnoliae officinalis seven-object soup

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] The raw materials of Houpu Qiwu Decoction Granules are as follows: Magnolia officinalis 24g, licorice 9g, rhubarb 9g, jujube 25g, citrus aurantium 10g, cassia twig 6g, ginger 15g;

[0131] The preparation method is as follows: respectively take magnolia officinalis, licorice, rhubarb, jujube, citrus aurantium, cassia twig and ginger in selected parts by weight, add water to decoct twice, add 12 times the amount of water for the first time, decoct for 2 hours, Add 10 times the amount of water for the second time, decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.30 at 60°C, dry it, add conventional excipients, and make clinical acceptable granules.

Embodiment 2

[0133] The present embodiment establishes the method for the fingerprint of Hopu Qiwu Decoction granule, comprises the following steps:

[0134] Take the granules of Houpu Qiwu Decoction to be tested, grind it finely, take 1g, weigh it accurately, put it in a stoppered conical flask, add 25mL of methanol aqueous solution with a volume concentration of 80% precisely, weigh it, treat it with ultrasonic for 30 minutes, take it out , allowed to cool, then weighed again, with 80% aqueous methanol solution to make up the lost weight, shake well, filter, and get the filtrate to obtain the test solution;

[0135] Take an appropriate amount of naringin reference substance, weigh it accurately, add methanol aqueous solution with a volume concentration of 80% to make a solution containing 4 mg of naringin per 1 mL, shake well, and obtain the reference substance solution;

[0136] Using octadecylsilane bonded silica gel as filler, acetonitrile as mobile phase A, and 0.1% phosphoric acid a...

Embodiment 3

[0139] The present embodiment establishes the method for the fingerprint of Hopu Qiwu Decoction granule, comprises the following steps:

[0140] Take the granules of Houpu Qiwu Decoction to be tested, grind it finely, take 0.5g, accurately weigh it, put it in a stoppered Erlenmeyer flask, add precisely 10mL of methanol aqueous solution or methanol with a volume concentration of 95%, weigh it, and ultrasonically reflux or Shake for 60 minutes, take it out, let it cool, weigh again, make up the lost weight with methanol water or methanol with a volume concentration of 95%, shake well, filter, and take the subsequent filtrate to obtain the test solution;

[0141] Take an appropriate amount of naringin reference substance, weigh it accurately, add methanol aqueous solution with a volume concentration of 95% to make a solution containing 1 mg of naringin per 1 mL, shake well, and obtain the reference substance solution;

[0142] Using octadecylsilane bonded silica gel as filler, ac...

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Abstract

The invention relates to a detection method of a medicinal preparation of cortex magnoliae officinalis seven-object soup. According to the method, by optimizing an extraction solvent, extraction time and an extraction method, various chemical components in the medicinal preparation of the cortex magnoliae officinalis seven-object soup are furthest extracted; by optimizing an chromatographic column, a mobile phase and an elution mode of the mobile phase, the various chemical components are better separated; thus a method for a fingerprint spectrum of the medicinal preparation is established, and relatively comprehensive spectrum information is acquired; further, by optimally selecting No.8 peak naringin as an internal reference peak, the facts that in common characteristic peaks, a No.9 peak is neohesperidin, a No.14 peak is ammonium glycyrrhetate, a No.15 peak is aloe-emodin, a No.17 peak is rhein, a No.18 peak is emodin, a No.19 peak is honokiol and a No.21 peak is magnolol are affirmed, and relative retention time of 21 common characteristic peaks is determined; by combining information of multiple chromatography peaks in the fingerprint spectrum, the quality can be comprehensively and systematically detected.

Description

technical field [0001] The invention belongs to the field of drug analysis, and in particular relates to a method for detecting a drug preparation of Houpu Qiwu Decoction. Background technique [0002] One side of Hopu Qiwu Decoction comes from "Synopsis of the Golden Chamber" written by Zhang Zhongjing in the Eastern Han Dynasty. Floating and counting, diet remains the same. Hopu Qiwu Decoction is the main one. It has the effect of promoting qi and eliminating fullness, relieving exterior and dispelling cold. It has been widely used in modern clinical practice for acute enteritis, habitual constipation, chronic gastroenteritis, intestinal obstruction, etc. Treatment. [0003] The composition of traditional Chinese medicine is complex, and the active part is often not a single component. Using a single component as a quality control indicator has become less and less suitable for the quality control requirements of traditional Chinese medicine. Therefore, traditional Chine...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/062
Inventor 解素花韩志玲杜菁高云佳易剑平李东影屠鹏飞崔凯茜
Owner TONG REN TANG TECH CO LTD
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