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Preparation process of aloe emodin

A technology for the preparation of aloe-emodin, which is applied in the field of organic matter preparation, can solve the problems of low product purity and less content in the preparation process of aloe-emodin, and achieve the effects of high purity, high product rate, and improved utilization rate

Inactive Publication Date: 2017-01-04
LUOTIAN YONGFEI CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of less content and low product purity in the existing aloe-emodin preparation process, the present invention proposes a preparation process of aloe-emodin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step a) Put 100mol water, 10mol hydrochloric acid, and 10g aloe extract into the enamel dissolving kettle, heat to 30°C to dissolve, let it stand for 1 hour, take the supernatant and transfer it to another enamel dissolving kettle, discard the sediment as filter residue, filter residue It is a polysaccharide substance, which can be decomposed by burning. After the clear liquid is transferred to another enamel dissolving kettle, 12g of ferric chloride is dropped into, after stirring completely, cooling crystallization, centrifugation, the centrifugal speed is 500r / min, the wet product of aloe-emodin is obtained, and the wet product is dried to obtain 9g of aloe Crude emodin.

[0029] Step b) Put the crude product of aloe-emodin into the dissolution kettle, add 142.5g of toluene as the solvent, heat up to 50°C for dissolution, press filter the solution, take the filtrate to the crystallization kettle, cool and crystallize, and conduct crystallization on the crystallized s...

Embodiment 2

[0032] Step a) Put 10mol water, 100mol hydrochloric acid, and 10g aloe extract into the enamel dissolving kettle, heat to 50°C to dissolve, let it stand for 10 hours, take the supernatant and transfer it to another enamel dissolving kettle, discard the sediment as filter residue, filter residue It is a polysaccharide substance, which can be decomposed by burning. After the clear liquid is transferred to another enamel dissolving kettle, 20g of ferric chloride is dropped into, after stirring completely, cooling crystallization, centrifugation, the centrifugal speed is 1000r / min, the wet product of aloe-emodin is obtained, and the wet product is dried to obtain 9.5g Crude aloe-emodin.

[0033] Step b) Put the crude product of aloe-emodin into the dissolution kettle, add 90g of toluene as solvent, heat up to 40°C to dissolve, press filter the solution, take the filtrate to the crystallization kettle, cool and crystallize, and centrifuge the crystallized solution , and the centri...

Embodiment 3

[0036] Step a) Put 100mol water, 100mol hydrochloric acid, and 10g aloe extract into the enamel dissolving kettle, heat to 35°C to dissolve, let it stand for 8 hours, take the supernatant and transfer it to another enamel dissolving kettle, discard the sediment as filter residue, filter residue It is a polysaccharide substance, which can be decomposed by burning. After the clear liquid was transferred to another enamel dissolving kettle, 180g of ferric chloride was dropped into, after the stirring was completed, cooling and crystallization, centrifugation, the centrifugal speed was 800r / min, to obtain the wet product of aloe-emodin, and the wet product was dried to obtain 9.1g Crude aloe-emodin.

[0037] Step b) Put the crude product of aloe-emodin into the dissolution kettle, add 130g of toluene as solvent, heat up to 48°C for dissolution, press filter the solution, take the filtrate to the crystallization kettle, cool and crystallize, and centrifuge the crystallized solution...

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Abstract

The invention belongs to the field of preparation of organic matters and particularly relates to a preparation process of aloe emodin. The preparation process comprises the following steps: (a) carrying out hydrolysis oxidation on an aloe extract as a raw material, so as to obtain an aloe emodin crude product; and (b) purifying the aloe emodin crude product. The preparation process has the beneficial effects of high product yield and product precision.

Description

technical field [0001] The invention belongs to the field of organic matter preparation, in particular to a preparation process of aloe-emodin. Background technique [0002] In the research and development of anti-tumor drugs, the screening of anti-tumor drug lead compounds based on biological target molecules is one of the research hotspots of anti-tumor drugs. The formation of G-quadruplex DNA can effectively inhibit the activity of telomerase and the elongation of telomeres, thereby curbing the massive proliferation of tumor cells. Therefore, compounds that can induce GDNA to form a G-quadruplex structure or specifically bind to G-quadruplex and stabilize it are expected to inhibit the growth of tumor cells, thereby achieving anticancer effects. The screening and structural design of compounds for the targets of anticancer drugs is a hot spot that chemists and biologists are paying close attention to. [0003] Aloe-emodin is the antibacterial active ingredient of rhubar...

Claims

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Application Information

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IPC IPC(8): C07C50/34C07C46/10
CPCC07C46/10C07C50/34
Inventor 姚进姚莎张浩
Owner LUOTIAN YONGFEI CHEM
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