221results about How to "Three wastes less pollution" patented technology

This invention discloses a preparation method of solid-phase peptide synthesizing bivalirudin. It includes the following steps: taking any one of triphenyl methyl chloride resin, 4-methyl-triphenyl methyl chloride resin, 4-methoxy-triphenyl methyl chloride resin, 2-chlorine-triphenyl methyl chloride resin, or Wang resin as the starting raw materials, connecting amino acids in turn according to the method of solid-phase synthesis, to get a protective 28-peptide resin, removing Fmoc-protective group in turn, side-chain protecting group and cutting the peptide to get a crude, then purifying the crude through C18 (or C8) high-pressure column to get bivalirudin exquisite article. In this invention, the peptide yield of every step is more than 99%, and the total yield is 14%.

The invention relates to a preparation method of prothioconazole. The preparation method comprises that a compound IV undergoes a reaction at 20 to 120 DEG C in the presence of an oxidizing agent and a solvent, and after the reaction, the product is treated to form prothioconazole. The preparation method has mild reaction conditions, utilizes cheap and easily available raw materials, has simple processes, is environmentally friendly and clean in regents and reaction processes, greatly reduces three wastes, is suitable for industrial production, and realizes a high yield of a final product and high content.

The invention discloses a method for synthesizing triazine ring, which is implemented by reacting aqueous methylhydrazine solution with ammonium sulfocyanate, and then preparing amino methyl sulfourea methanol solution by using methanol; performing cyclization reaction on amino methyl sulfourea methanol solution with dimethyl oxalate and sodium methylate, adjusting pH value with hydrochloric acid after finishing cyclization reaction, removing excessive sodium methylate, and filtering to prepare triazine ring sodium salt; aciding out the triazine ring sodium salt to obtain a crude triazine ring product; agitating the crude triazine ring product with hot water, washing, cooling, crystallizing, and drying to obtain a fine triazine ring product. The invention has high yield and low material cost, reduces labor intensity and pollution of waste gas, waste water and industrial residue.

The present invention discloses non-enantioselective preparation process of emtricitabine. The preparation process includes condensation of glyoxalic acid as the initial material and 2, 5-dihydroxy-1, 4-dithiane under the asymmetric induction of optically active alcohol ester to obtain trans-5-hydroxy-1, 3-oxythiacyclopentane-2-carboxylate; halogenating and coupling with silylated 5-flucytosine, and reducing to obtain initial product; reaction with salicylic acid to form salt, purification and separation to obtain optically pure emtricitabine. The present invention has mild reaction condition, simple operation, low cost, less environmental pollution and high product purity reaching medicinal standard, and is suitable for industrial production. The product is used in treating hepatitis B and AIDS.

The invention relates to carbonyl terminated hyperbranched polycarbonate capable of emitting bright fluorescence. Glycerol and diethyl carbonate are used as raw materials; a simple and controllable ester exchange condensation method is used for synthesizing the terminated hyperbranched polycarbonate; then, tert-Butyl acetoacetate is used for termination to obtain the hyperbranched polycarbonate. The synthesized hyperbranched polycarbonate does not contain pi keys such as benzene rings; the addition of fluorescent powder is not needed; the bright blue fluorescence can be given out; the characteristics of simple process, controllable process and low three-waste pollution are realized; in addition, the product stability is high; the toxicity is high; the biodegradability is high; the light intensity is high; the application range is wide.

The invention discloses a synthetic method of 3, 5-dichloro-2, 4-difluoroaniline. The synthetic method takes distillation residues which are generated in the manufacturing technology that 2,6-dichlor fluorbenzene is nitrified to prepare 2, 4-dichloro-3-fluoronitrobenzene as raw material, and the distillation residues are chlorinated through chlorine gas and fluorated through potassium fluoride so as to prepare 3, 5-dichloro-2, 4-difluoro nitrobenzene; and finally, 3, 5-dichloro-2, 4-difluoro nitrobenzene is reduced to obtain 3, 5-dichloro-2, 4-difluoroaniline. The synthetic method adopts by-products that are generated in the conventional manufacturing technology line as raw material, is directly used for synthesizing 3, 5-dichloro-2, 4-difluoroaniline without any treatment, is characterized by low price of raw material, full resource utilization, mild reaction conditions, high yield coefficient of products, low manufacturing cost and the like compared with a conventional method for preparing 3,5-dichloro-2,4-difluoroaniline, is easy to get raw material, and is very suitable for industrialized production.

The invention relates to preparation of octreotide acetate and an octreotide acetate injection pharmaceutical composition. Specifically, the invention relates to a method for preparing the octreotide acetate; the method comprises the following steps: taking merrifield resin as a starting raw material and preparing Boc-Thr(tBu)-OH into cesium salt; sequentially connecting amino acid with protecting groups according to a solid-phase synthesis method to obtain protected octapeptide resin; removing Boc-protecting groups in sequence by utilizing HCl / isopropyl alcohol and carrying out peptide linking reaction by utilizing a condensing agent; reducing with palladium-carbon / hydrogen; meanwhile, chopping off a peptide chain to obtain reduced octreotide; ventilating air under the condition that the pH (Potential of Hydrogen) is 8 to 9 to form a ring by a disulfide bond, so as to obtain an octreotide crude product; separating and purifying the octreotide crude product through a C18 column to prepare refined octreotide. The invention further relates to the octreotide acetate injection pharmaceutical composition. The method for preparing the octreotide acetate and the octreotide acetate injection pharmaceutical composition, provided by the invention, have the excellent technical effects shown in the description.