69 results about "Octreotide acetate" patented technology

The invention discloses a method for preparing a hammer-shaped palladium nanoparticle by utilizing octreotide acetate as a template. The method mainly comprises the steps of: dissolving the octreotide acetate by using hydrochloric acid with pH of 2-3; adjusting the octreotide acetate into an acid solution; then adding a palladium dichloride solution into the well-adjusted solution according to a molar ratio of 1: 4-6; placing the mixed solution into a water-bathing constant temperature vibrator for incubation for 20-26 hours at 100-200 rpm and at 13-25 DEG C; and then adding a sodium borohydride reducing agent having a molar ratio to the octreotide acetate of 1: 45-55 into the well-incubated solution drop by drop to change the solution from light yellow to grey brown so as to finish the preparation of the octreotide acetate-hammer-shaped palladium nanoparticle. The method for preparing the hammer-shaped palladium nanoparticle by utilizing the octreotide acetate as the template has the advantages of a simple preparation process, low price, easy source, easy control of reaction, high yield and the like.

The present invention provides a sterile solution comprising octreotide acetate in a pharmaceutically acceptable vehicle, wherein solution is present as a reservoir in a multiple dose pen injection device, the device being adapted to subcutaneously inject a portion of the said reservoir in multiple daily doses and further being adapted to provide multiple portions of the said solution, while the reservoir remains sterile.

The invention provides an octreotide acetate freeze-dried combination for injection, which comprises octreotide acetate, mannitol and a proper amount of buffer substances, wherein the mass ratio of the octreotide acetate to the mannitol is 1:(450-500); and the buffer substances are lactic acid and sodium bicarbonate and can be tartaric acid and sodium tartrate. The invention also provides a preparation method of the composition. The composition provided by the invention is produced by adopting an aseptic technique; by striving to make the technological breakthrough in optimal pH range and optimal preparation temperature in a liquid medicine preparation process, the product stability is improved; and finally, a freeze-dried product is prepared. By adopting a quick-freezing mode for pre-freezing, a finished product has low related substance content and good re-solubility, can be preserved at room temperature for two months and can be refrigerated for two years, thereby facilitating the product transportation and delivery. By clinically matching with a solution, the combination has good stability and low local injection irritation. The invention provides a safe and effective octreotide acetate freeze-dried combination for injection, which has good and controllable quality, for clinics.