61results about How to "The synthesis method is safe" patented technology

The invention discloses a preparation method of magnetic / gold nano particles. The preparation method comprises the following steps: firstly adopting a co-precipitation method to prepare the magnetic Fe3O4 nano particles; polymerizing the dopamine in-situ on the surfaces of the magnetic particles to obtain Fe3O4 nano particles modified by the poly dopamine; introducing polyphenol and amino groups to the surfaces of the Fe3O4 nano particles; absorbing the nano gold seeds on the surfaces of the modified magnetic particles through the static action; adopting the nano gold which is absorbed on the surfaces of the magnetic particles as the seed, adopting the polyphenol on the surfaces of the magnetic particles as a reducing agent, gradually adding the chloroauric acid liquid to gradually produce the gold layers on the surfaces of the magnetic particles to obtain the core-shell magnetic / gold nano particles. The nano particles have good water dispersion and strong magnetic respond performance. The diameters of the nano particles are 30-100 nanometers, the saturation magnetization is 30.1-38.7emu / g, and the nano particles are superparamagnetic. The nano particles have wide application prospect on the fields of targeted drug controlled release, thermal therapy, separation of protein and enzyme, etc.

This invention discloses a cellulose base chelated textile fiber and the synthetic method and the application. The chelated textile fiber takes the native cellulose textile fiber as the raw material. Through the duplet bond and the shrinkage glycerin compound carries on the free radical stem grafting copolymerization, we obtain the cellulose textile fiber which the epoxy activates, this epoxy activates the cellulose textile fiber and the polyethylene multi-amines respond a lot the amine chelated textile fiber, the multi-amine chelated textile fiber continues with the chloroacetic acid to respond, multi-amine multi-carboxylic acid chelated textile fiber. This kind of cellulose base chelated textile fiber has the fine trapping performance to the harmful heavy metal ion, and the synthetic method is simple, safe. the synthesis cost is low, too.

The invention belongs to the technical fields of catalysts and xylosic acid, and discloses a modified carbon nitride photocatalyst, a preparation method thereof, and a method for synthesizing xylosicacid by photocatalytic oxidation of xylose. The preparation method of the photocatalyst comprises the following steps: (1) uniformly mixing a nitrogen-containing organic matter precursor with a low-melting point chlorine-containing salt compound in a solvent, and removing the solvent to obtain a solid product; and (2) performing calcining, acid treatment, washing and drying on the solid product toobtain the modified carbon nitride photocatalyst. The modified carbon nitride photocatalyst is used for photocatalytic oxidation of xylose to synthesize xylosic acid. The method for synthesizing xylosic acid is characterized in that the photocatalytic oxidation of the xylose is carried out in an alkaline solution under an illuminating condition in the presence of the modified carbon nitride photocatalyst to obtain the xylosic acid. The photocatalyst has the advantages of good thermal stability, high catalytic activity and good recyclability. The method for successfully synthesizing xylosic acid by photocatalytic oxidation of xylose through using the photocatalyst has the advantages of good safety, non-toxicity, quick effect, low energy consumption, high yield of the xylosic acid, and easiness in realizing industrial production.

The invention provides a synthetic method for preparing alpha, beta-unsaturated ketone, and relates to the technical field of medicines, pesticides, spices and the like. The synthetic method is characterized in that under the catalysis of calcium hydroxide, in a low-concentration alcohol solution, the alpha, beta-unsaturated ketone is directly synthesized by aldehyde ketone through one-step aldol condensation. The calcium hydroxide as a catalyst used in the method is cheap and rich, and after the completion of the reaction, carbon dioxide can be introduced to remove calcium hydroxide. As the method uses the low-concentration alcohol solution, cleanness and environmental protection are achieved. Therefore, the synthetic method is eco-friendly, small in equipment corrosion, durable and more suitable for industrial production.

The invention relates to a preparation method for a carbon quantum dot fluorescent probe used for detection of the concentration of nitric oxide in organisms. The carbon quantum dot is a powdery solidwith excellent water solubility, is synthesized from citric acid and L-cysteine through a microwave-assisted method, and has extremely high quantum yield which is up to 85%. The preparation method for the carbon quantum dot comprises the following steps: 1) dispersing and dissolving the citric acid and the L-cysteine in deionized water; 2) carrying out stirring and ultrasonic dispersion, and allowing the citric acid and the L-cysteine to be uniformly dispersed in a solution; 3) transferring a mixed solution into a microwave oven, and carrying out heating for 2 to 8 min; 4) carrying out cooling to a room temperature, adding water, and carrying out dissolving; 5) transferring an obtained solution into a centrifuge, and carrying out centrifuging at a high speed; and 6) subjecting a centrifuged solution to filtering and drying operations so as to prepare the carbon quantum dot. The carbon quantum dot prepared by using the method provided by the invention has the advantages of high fluorescence quantum yield, good chemical stability, photobleaching resistance and biological compatibility, and applicability to detection of the concentration of the nitric oxide in the organisms.

The invention discloses a method for synthesizing heat-sensitive and biodegradable hydrogel. The method comprises the following steps: preparing a biodegradable cross-linking agent, namely polymerizing lactic acid dimmer lactide and hydroxyethyl methylacrylate to form an intermediate, introducing glucosan to synthesize the biodegradable cross-linking agent by virtue of a chemical reaction; and preparing the heat-sensitive and biodegradable hydrogel, namely dissolving N-isopropylacrylamide, an initiator and the biodegradable cross-linking agent in bovine serum albumin, adding a photoinitiator, performing light initiated polymerization, thereby obtaining the heat-sensitive and biodegradable hydrogel. The poly-N-isopropylacrylamide gel synthesized by the method is decomposed in a certain time due to the degradable structure of the cross-linking agent, and the decomposition products such as polylactic acid and glucosan can participate in human metabolism.

The invention relates to the technical field of biology, in particular to a method for biosynthesizing nano-silver through photoinduction of imperata leaf extract. The method comprises the following steps: 1) picked imperata leaves are cleaned, dried and grinded to powder; ultrapure water is added in the powder for oscillating, extracting and centrifugating to obtain supernatant; and the supernatant is frozen and dried to obtain the imperata leaf extract; and 2) the imperata leaf extract in the step 1) is taken as a reaction matrix; AgNO3 solution is added, so that the concentration of the reaction matrix in obtained mixed solution is 10-50 mg / mL, and the concentration of AgNO3 is 1-3 mM; and nano-silver particles are prepared through reaction under sunlight irradiation or LED lamp irradiation. The biosynthesizing method is safe, environment-friendly, wide in synthetic material source and fast in synthesizing speed, can finish the reaction within 90-120 minutes, and is a green, safe and efficient biosynthesizing method.

The invention provides a guanidine substituted aromatic compound modified high polymer material shown in a formula (1). The guanidine substituted aromatic compound modified high polymer material comprises a cationic high polymer skeleton and guanidine substituted aromatic compound functional groups, and the guanidine substituted aromatic compound functional groups are covalently connected to the surface of the cationic high polymer skeleton. The invention further provides a preparation method of the high polymer material and an application of the high polymer material as a nucleic acid and protein molecule transport carrier. The synthesis method has low cost and is simple; the synthesized high polymer material is low in cytotoxicity and has the good application prospect.

The invention relates to a preparation method of 4-benzyl piperazi ethyliminumacyl (formimidoyl benzol) hydrazine compounds, and specifically relates to a method for preparing a compound of the following formula I or its pharmaceutically acceptable salts or solvates, wherein, R1, R2, R3 and R4 are respectively selected from hydrogen atom, hydroxyl, halogen, C1-8 alkenyl, C1-8 alkyl and sulfonamido. The method comprises the step of: (1) in a suitable organic solvent, reacting hydrazine hydrate with the compound of formula 1a so as to obtain the compound of formula 1b; (2) with the existence of alkali, reacting 2-chloracetyl iminoiacetate hydrochloride with the compound of formula 1b in a suitable organic solvent so as to generate the compound of formula 1c; (3) in the presence of alkali and in a proper organic solvent, reacting the compound of formula 1c with the compound of formula 1d, thus obtaining the compound of formula I. The method of the invention is characterized by security, simplicity and convenient operation.

The invention relates to a preparation method of an indium antimonide nanocrystal, belonging to the technical field of a composite nanocrystal material. The product of the preparation method is the indium antimonide nanocrystal. The preparation method of the indium antimonide nanocrystal comprises steps of: mixing Sb2O3, In(NO3)3.9 / 2H2O, PEG200 (polyethylene glycol) with ethanediol in a 250ml three-necked flask, wherein the mixture is taken as growth solution; dissolving NaBH4 into ethidene diamine to be taken as storage solution; performing the oil bath on the growth solution until the temperature of the solution is 140 DEG C under the protective atmosphere of the nitrogen, and keeping the magnetic stirring for 30 minutes; adjusting the oil bath temperature at reaction temperature (120 DEG C-180 DEG C); fast injecting the storage solution into the growth solution (-2S) by a needle cylinder, and keeping the oil bath temperature and the magnetic stirring; sampling reaction solution within the reaction time from 5 minutes to 5 hours; and adding the alcohol with proper amount into the sampled reaction solution, and centrifuging for 20 minutes at the rotation speed of 15000rpm to separate the product (InSb). The preparation method is a liquid phase preparation method for preparing the InSb nanocrystal at a lower temperature (120-180 DEG C), wherein the method is high-efficiency, low-priced, free of catalytic agent and relatively safe; the prepared product is stable in property, and even in particle; and the preparation method can be used for providing the indium antimonide nanocrystal which is suitable for a high-speed electronic component, a magnetic component, and a far infrared-waveband photoelectric component.

The invention belongs to the field of chemical synthesis, and discloses a method for synthesizing 4-S-2', 3', 5'-O-triacetyluridine. According to the synthesis method, a compound 2', 3', 5'-O-triacetyluridine is used as a raw material, phosphorus pentasulfide and a Lawesson's reagent are combined to be used as a vulcanizing agent, 1,4-dioxane is used as a solvent for chemical reaction, and finally4-S-2', 3', 5'-O-triacetyluridine is prepared. By the method for synthesizing 4-S-2', 3', 5'-O-triacetyluridine provided by the invention, the reaction time is shortened, and moreover, the vulcanization efficiency is greatly improved. According to the synthesis method provided by the invention, the cost is reduced, the reaction aftertreatment is simple and convenient, and meanwhile, the yield ofa reaction thionucleoside compound is improved.

The invention belongs to the field of chemical synthesis and discloses a synthesis method for 4-S-5-Br-2',3',5'-O-triacetyluridine. The synthesis method comprises the steps that a compound 5-Br-2',3',5'-O-triacetyluridine serves as a raw material, phosphorus pentasulfide and a Lawesson reagent are combined to serve as a vulcanization reagent, 1,4-dioxane serves as a solvent, and a chemical reaction is carried out to finally prepare the 4-S-5-Br-2',3',5'-O-triacetyluridine. The synthesis method for the 4-S-5-Br-2',3',5'-O-triacetyluridine has the advantages that the reaction time is shortened,and the vulcanization efficiency is greatly improved. The synthesis method reduces the cost, the treatment after the reaction is simple and convenient, and meanwhile the yield of the thionucleoside compound after the reaction is increased.

The invention discloses a preparation method of zinc 5, 5'-azotetrazole, a green primary explosive. The method comprises: taking 5-aminotetrazole as the starting material, which is oxidized into sodium 5, 5'-azotetrazole by an alkaline oxidation method, then adopting pure water as the base solution, using a metering pump to control the feeding speed of a zinc acetate solution and a sodium 5, 5'-azotetrazole solution, and adding them dropwisely into the base solution for a combination reaction, then carrying out heat preservation, cooling, pumping filtration, washing, dehydration, and drying, thus obtaining a finished product of zinc 5, 5'-azotetrazole. The zinc 5, 5'-azotetrazole of the invention has the advantages of simple and safe synthesis method, low toxicity or no toxicity raw materials, low cost, no black residue after explosive decomposition, and small residue amount, generation of nitrogen as general gas product, no environmental pollution, as well as good explosion performance, thus being a green primary explosive.

The invention discloses an imidazolecarboxylic acid complex and a synthesis method and application thereof. The chemical formula of the imidazolecarboxylic acid complex is [Cd(L)<1 / 2>.2H2O]n, wherein a ligand L is 2,2'-(1,2-phenyl)bis(1H-imidazole-4,5-dicarboxylic acid). The brand new imidazolecarboxylic acid complex is obtained by taking 2,2'-(1,2-phenyl)bis(1H-imidazole-4,5-dicarboxylic acid) as a bridging ligand and constructing a coordination polymer by means of 2,2'-(1,2-phenyl)bis(1H-imidazole-4,5-dicarboxylic acid) and metal ions Cd<2+>. According to the method, Cd(Ac)2.2H2O and 2,2'-(1,2-phenyl)bis(1H-imidazole-4,5-dicarboxylic acid) react through a hydrothermal method, the ligand and the corresponding metal ions are subjected to coordination, and then the brand new imidazolecarboxylic acid complex is obtained. The synthesis method is simple, convenient to operate, safe, mild in reaction condition, high in yield and purity and beneficial for subsequent testing.

The invention provides a synthesis method of tetracarboxylic dianhydride with a fluorinated rigid structure. According to the method, trifluoromethanesulfonic acid, trifluoroacetic acid and / or sulfuric acid is adopted to replace hydrofluoric acid to serve as a catalyst to achieve conversion from 3,4-dimethylphenol or 3,3',4,4'-tetramethyldiphenyl ether to xanthene tetracarboxylic dianhydride, so that the whole synthesis method has the advantages of being efficient, safe and controllable.

The invention belongs to the technical field of biosynthesis, and provides a strain of Talaromyces sp FL15 and application thereof in mediating nano-silver biosynthesis. The Talaromyces sp FL15 provided by the invention is Talaromyces sp, the strain is preserved in China Center for Type Culture Collection, the address is Wuhan University, Wuhan City, China, the preservation date is October 17, 2019, and the preservation number is CCTCC NO: M 2019832. The Talaromyces sp FL15 is found in huperzia serrata endophytic fungi, and the fungi are found to have the ability of mediating nano-silver synthesis. By optimizing synthesis conditions, the obtained nano-silver has high yield, smaller size and obvious bacteriostatic effect.

The invention discloses a bismuth tungstate catalyst and a preparation method thereof as well as application of combined ultrasound to catalysis and degradation of antibiotics. A hydrothermal synthesis method is adopted to synthesize the bismuth tungstate catalyst with a square plate-shaped crystal form under the condition that the pH value is equal to 5. A catalyst synthesis method is simple, convenient, safe, and easy for post-treatment. The degradation rate of a ciprofloxacin hydrochloride water solution catalyzed and degraded by a catalyst and ultrasonic combination sound is greater than that of a ciprofloxacin hydrochloride water solution independently degraded by bismuth tungstate, and the bismuth tungstate has better sound catalytic activity. The bismuth tungstate is used for catalysis and ultrasonic degradation of the ciprofloxacin hydrochloride water solution so as to enable the degradation efficiency of the ciprofloxacin hydrochloride water solution to be improved, and the bismuth tungstate catalyst has guiding significance for the synthesis of a more effective sound catalysis nano material.

The invention relates to a synthesis method of a GQDs modified ZnO composite nanostructure gas sensitive material for detecting dimethylamine gas. The method comprises the following steps: adding GQDsin different proportions into ZnO nanosheets, and synthesizing to obtain the GQDs-modified ZnO composite nanostructure gas sensitive material, namely GQDs-ZnO. The GQDs-modified ZnO composite nanostructure gas sensitive material provided by the invention has an appropriate porous structure and a relatively high specific surface area, and the synthesis method is green, simple and safe, relativelysimple and convenient in raw material acquisition and relatively high in practical degree. When being used as a gas sensitive material, the invention shows excellent gas sensitive performance at the working temperature of 160 DEG C, shows relatively high sensitivity, relatively high linearity, excellent selectivity and relatively good repeatability on dimethylamine gas, has a gas detection lower limit of 0.1 ppm, and has huge potential in the aspect of dimethylamine gas detection.

The invention discloses a method for preparing an umeclidinium bromide intermediate compound as shown in a formula 3, and further discloses a synthesizing method of umeclidinium bromide. The synthesizing method effectively avoids unstable phenyl lithium with high price and toxicity, corresponding quinuclidine building reaction steps are omitted, reaction steps are greatly decreased, and reaction efficiency and yield are improved. The synthesizing method is shorter in reaction step, mild in operation condition, high in safety, low in environmental pollution and higher in yield, and a good basisis provided for industrial amplification of the umeclidinium bromide.

The invention discloses a xylose compound with a terminal group containing a HS-(PEG)-2-O branch chain and a synthesis method of the xylose compound with the terminal group containing the HS-(PEG)-2-O branch chain. The compound is shown as the formula I (the formula is shown in the description). The synthesis method comprises the following steps that xylose is subjected to an acetylation or benzoylation reaction and terminal group glycosylation sequentially and then reacts with potassium thioacetate in a N,N-dimethylformamide solution at normal temperature, Ac or Bz protecting group removal is finally conducted with sodium methylate / methanol, and then the xylose compound with the terminal group containing the HS-(PEG)-2-O branch chain is obtained. The xylose compound with the terminal group containing the HS-(PEG)-2-O branch chain shows the good water solubility due to the fact that multiple -OH are contained and can be applied to quantum dot surface modification due to the fact that -SH is contained; the application field of the xylose compound is widened due to the fact that the xylose compound has multiple chiral centers, and therefore specific identifiability of glucose and combination of quantum dot special material properties are achieved.

The invention relates to an environment-friendly synthesis method of nitrate, which comprises the following steps: adding organic acid and nitric acid used as catalysts into a nitration kettle according to preset percents to form a mixture, wherein the inside of the nitration kettle is in a nitrogen protective atmosphere, and the reaction temperature inside the nitration kettle is controlled at 25-50 DEG C; and dropwisely adding alkyl alcohol into the mixture to carry out nitration, thereby obtaining the nitrate. The method can effectively overcome the defects of difficulty in waste acid after-treatment, long production process, inapplicability to nitration of water-sensitive and acid-sensitive substances, higher production cost, low atomic economical efficiency, poor selectivity, difficulty in product separation, severe environmental pollution and poor adaptability to raw materials.

The invention discloses a preparation method and application of antifreeze glycopeptides based on fructooligosaccharide modification, and belongs to the technical field of biology and food processing. The fructooligosaccharide carbohydrate chain is introduced into antifreeze peptide from different sources by a glycosylation grafting means to synthesize the antifreeze glycopeptides. The antifreeze glycopeptides have good antifreeze functions, and can be applied to low-temperature freeze preservation of cells, tissues, organs, microorganisms and frozen food. The freezing survival rate of the cells, the tissues and the microorganisms added with the antifreeze glycopeptides is obviously improved; when the antifreeze glycopeptides are applied to freezing preservation food, the stability of the regional quality of the freezing food can be well maintained; the food quality deterioration caused by freezing damage is obviously reduced.

The invention discloses a hydrogen evolution catalyst with a nickel hydroxide layer coated elemental ruthenium structure and a preparation method thereof. The catalyst comprises nickel hydroxide and ruthenium, elemental ruthenium is anchored on the surface of foamed nickel and is coated with a nickel hydroxide layer, and ruthenium chloride hydrate and foamed nickel are added into a sodium hydroxide solution to directly synthesize the required catalyst in a homogeneous reactor in a one-step hydrothermal mode. The nickel hydroxide nano sheet and the elemental ruthenium grow on the surface of thefoamed nickel in-situ, so that the use of an additional adhesive is avoided, the good conductivity and mechanical stability are ensured, and the catalytic performance of the catalyst in an alkaline environment is improved by utilizing the synergistic effect between the bi-functional active sites of nickel hydroxide and ruthenium; when the current density of the prepared catalyst in a 1.0 M KOH electrolyte solution is 10 mA.cm<-2>, the required over potential is 27.56 mV (vs RHE).

The invention discloses a preparation method of magnetic / gold nano particles. The preparation method comprises the following steps: firstly adopting a co-precipitation method to prepare the magnetic Fe3O4 nano particles; polymerizing the dopamine in-situ on the surfaces of the magnetic particles to obtain Fe3O4 nano particles modified by the poly dopamine; introducing polyphenol and amino groups to the surfaces of the Fe3O4 nano particles; absorbing the nano gold seeds on the surfaces of the modified magnetic particles through the static action; adopting the nano gold which is absorbed on the surfaces of the magnetic particles as the seed, adopting the polyphenol on the surfaces of the magnetic particles as a reducing agent, gradually adding the chloroauric acid liquid to gradually produce the gold layers on the surfaces of the magnetic particles to obtain the core-shell magnetic / gold nano particles. The nano particles have good water dispersion and strong magnetic respond performance. The diameters of the nano particles are 30-100 nanometers, the saturation magnetization is 30.1-38.7emu / g, and the nano particles are superparamagnetic. The nano particles have wide application prospect on the fields of targeted drug controlled release, thermal therapy, separation of protein and enzyme, etc.

The invention discloses a method for introducing fluorine ions into ZnMoO4 by a hydrothermal method. The method comprises the following steps: a, weighing molybdenum trioxide, dissolving themolybdenumtrioxide in deionized water, weighing zinc fluoride tetrahydrate, and adding into the obtained aqueous molybdenum trioxide solution; b, transferring a mixed solution obtained in step a into a reaction kettle, and carrying out a hydrothermal reaction for 12-24 hours at the temperature of 200-201 DEG C to obtain a yellow product; and c, repeatedly and centrifugally washing the yellow product obtained in step b with deionized water and ethanol, carrying out vacuum drying for 6-12 hours at the temperature of 50-80 DEG C, and grinding into powder to obtain ZnMoO4: F. According to the ZnMoO4: F material prepared by the invention, XPS, TG and the like prove that a certain amount of fluorine ions exist in crystal lattices, and the ZnMoO4: F material has visible light adsorption. The method disclosed by the invention exceeds the traditional method for preparing the fluorine-containing compound by using dangerous reactants such as HF and PVDF, and is a non-toxic and simple preparation method.

The invention relates to a synthesis method of high-purity odorless chlorphenesin. The method comprises the steps of S1, adding water, an inorganic base catalyst and parachlorophenol into a reaction tank, and stirring; S2, adding a phase transfer catalyst into the reaction tank, and heating; S3, dropwise adding glycidol into the reaction tank at a constant temperature, and carrying out condensation reaction on the glycidol and parachlorophenol under the catalytic action of an inorganic base catalyst to generate chlorphenesin; and S4, after the reaction is completed, obtaining chlorphenesin through a post-treatment method. According to the synthesis method of the high-purity odorless chlorphenesin, the reaction process is simple, and the obtained chlorphenesin is high in purity, free of parachlorophenol residues and odorless; and no industrial waste salt is generated in the production process, a small amount of generated low-concentration waste brine is subjected to three-dimensional electrolysis to realize open-loop degradation of organic matters in the wastewater, and the wastewater is discharged after being treated by anaerobic treatment, oxygen consumption treatment and other biochemical treatment measures and reaching the standard, so that the water body is not polluted.