The invention discloses a ceramic tile seam detergent which is prepared from the following raw materials: 3-4 parts of nonylphenol polyethenoxy ether, 2-4 parts of alkylphenol polyoxyethylene, 3-5 parts of castor oil polyethenoxy ether, 1-3 parts of Turkey red oil, 1-2 parts of p-toluenesulfonic acid, 2-5 parts of potassium permanganate, 3-5 parts of 4-aminobenzenesulfonic acid, 2-6 parts of tartaric acid, 3-5 parts of ethylene glycol monophenyl ether, 5-8 parts of 1,2-propanediol, 2-5 parts of thermosetting phenol aldehyde resin, 3-6 parts of polypropylene, 5-8 parts of amino resin, 5-10 parts of polycarbamate, 5-10 butyl acrylate, 3-5 parts of sodium carboxymethyl cellulose, 6-8 parts of sodium hexametaphosphate, 8-10 parts of paraffin emulsifier and 120-150 parts of deionized water. The ceramic tile seam detergent can thoroughly remove scales and resist stains and molds, and can not corrode the ceramic tile seam material; and after being applied to the ceramic tile seam, the ceramic tile seam detergent can remove dust and other oxides, can not leave wash marking after volatilization, is bright, can form a protective film on the surface, has the advantages of dirt resistance and low cost, and is convenient to use.