The invention discloses a preparation method of a
konjac glucomannan-
gelatin based
capsule. The method includes: using
mannose to degrade konjac refined
powder to obtain a
konjac glucomannan degradation solution; adding glycerin into the
konjac glucomannan degradation solution, stirring the substances evenly, then adding
gelatin, performing stirring till complete
dissolution of the
gelatin in the degradation solution so as to obtain mixed
sol; subjecting the mixed
sol to degassing, then carrying out standing glue dipping, freezing, shell pulling,
cutting and
drying, thus obtaining the konjac
glucomannan-gelatin based
capsule. The konjac
glucomannan-gelatin based
capsule has the characteristics of uniform capsule shell thickness, easy shell pulling and no rupture, no insert split, few bubble, no collapse, and no thin head. Strength and elastic detection of the capsule shell shows that the
friability is lower than that of single
gelatin capsule shell, and the elasticity is stronger.
Dissolution rate detection determines the
drug release effect of the konjac
glucomannan-
gelatin capsule, and the test finds that
drug release occurs at about 4-5min, and the
dissolution rate at about 60min is 95.5%.