Preparation method of konjac glucomannan-gelatin based capsule

Abstract

The invention discloses a preparation method of a konjac glucomannan-gelatin based capsule. The method includes: using mannose to degrade konjac refined powder to obtain a konjac glucomannan degradation solution; adding glycerin into the konjac glucomannan degradation solution, stirring the substances evenly, then adding gelatin, performing stirring till complete dissolution of the gelatin in the degradation solution so as to obtain mixed sol; subjecting the mixed sol to degassing, then carrying out standing glue dipping, freezing, shell pulling, cutting and drying, thus obtaining the konjac glucomannan-gelatin based capsule. The konjac glucomannan-gelatin based capsule has the characteristics of uniform capsule shell thickness, easy shell pulling and no rupture, no insert split, few bubble, no collapse, and no thin head. Strength and elastic detection of the capsule shell shows that the friability is lower than that of single gelatin capsule shell, and the elasticity is stronger. Dissolution rate detection determines the drug release effect of the konjac glucomannan-gelatin capsule, and the test finds that drug release occurs at about 4-5min, and the dissolution rate at about 60min is 95.5%.

Description

technical field [0001] The invention relates to a preparation method of capsules, in particular to a preparation method of konjac glucomannan-gelatin-based capsules. Background technique [0002] Capsules refer to preparations in which medicines are contained in empty capsules. The Chinese Pharmacopoeia defines capsules into two categories: hard capsules and soft capsules. The shape of the hard capsule is oval, which is composed of a capsule body and a cap, both of which have their own grooves and mold shapes, and can be tightly integrated into one body. Comparing capsules with tablets and other types of dosage forms, capsules are characterized by the ability to mask the bad smell of drugs, good absorption, and good stability of drugs. After more than 180 years of development, capsules have been used in oral solid preparations. It has become the main dosage form, and capsules have many advantages compared with other dosage forms, so the number of capsules in the pharmaceut...

AI Technical Summary

Problems solved by technology

This makes the output of gelatin empty capsules obviously oversupply, and the production capacity is excessive, which makes the industry of gelatin empty capsules extremely intense. This phenomenon has two sides. The advantage is that it can promote the development of the entire industry and promote the development of new gelatin-based capsule shells in the industry. It is the adverse consequences caused by the merchants seeing the benefits. The poisonous capsule incident that was exposed in 2012 was also due to the high price of gelatin and the complicated preparation process. Therefore, there are also problems with gelatin empty capsules, which will need to be solved by the pharmaceutical industry in the future.

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