97results about How to "Long-term release" patented technology

This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.

The invention relates to a chewing gum comprising at least one biodegradable polymer, wherein the molecular weight of said polymer is at least 105000 g / mol (Mn). According to the invention, it has moreover been realized that this problem may be effectively dealt with by increasing the molecular weight of at least one of the biodegradable polymers in the chewing gum when compared to conventional chewing gum polymers and thereby increasing the robustness of the chewing gum with respect to softeners, emulsifiers and e.g. flavor.

The invention discloses a trace element-doped porous calcium carbonate ceramic, and a preparation method and application thereof, belonging to the field of medical materials for bone repair. The preparation method disclosed by the invention comprises the following steps: doping Mg, Sr, Zn, Si, Cu and other trace elements in a human body into calcium carbonate through a chemical precipitation method, or doping trace elements into low-temperature phosphate bioglass used as a sintering binder, uniformly mixing the trace element-doped calcium carbonate powder, the glass binder and pore forming agent, then forming, performing isostatic pressing treatment, sintering, and removing the pore forming agent to obtain the trace element-doped porous calcium carbonate ceramic. The trace element-doped porous calcium carbonate ceramic prepared by the invention has high strength and porosity, controllable degradation rate, long-term slow release of the doped trace element ions and favorable bone conductibility and inductivity, and is a novel artificially synthesized bone repair material.

The invention discloses a preparation method of injectable chitosan grafted cyclodextrin compound drug-carrying hydrogel. The preparation method comprises the steps of carrying out amination and hydroformylation on cyclodextrin, reacting by virtue of hydroformylated cyclodextrin with chitosan so as to obtain chitosan grafted cyclodextrin, soaking molecules of obtained chitosan grafted cyclodextrin into medical liquid, uniformly stirring, filtering, carrying out freeze drying so as to obtain drug-carrying chitosan grafted cyclodextrin, adding drug-carrying chitosan grafted cyclodextrin into a chitosan water solution, adding beta-sodium glycerophosphate, so as to obtain the injectable chitosan grafted cyclodextrin compound drug-carrying hydrogel. The preparation method has the beneficial effects that reaction conditions are mild, and the operation is relatively simple and convenient; the stability of a drug concentration in a gel system of the prepared hydrogel can be maintained for a long time, and a drug can be effectively and controllably released for a long time, so that the utilization rate of the drug is increased; and the preparation method has relatively wide application prospects.

The invention discloses an ecological slow-release carbon source, and a preparation method and an application thereof. The preparation method comprises the following steps: carrying out destructive distillation treatment and pyrolysis on a straw material, and then drying to a constant weight to obtain a basic solid-phase slow-release carbon source; and immobilizing a denitrifying bacteria liquid on the basic solid-phase slow-release carbon source to obtain the ecological slow-release carbon source. In the preparation process of the ecological slow-release carbon source, medium-low temperaturedestructive distillation treatment and pyrolysis treatment destroy a lignocellulose structure, reduce the length of a cellulose molecular chain, reduce the polymerization degree and improve the availability of microorganisms for cellulose and hemicellulose, and meanwhile, the treated structure has porosity, the surface area is increased, and the carbon source is beneficial to long-term release. The ecological slow-release carbon source provided by the invention can maintain release of the carbon source for a long time, the average removal rate of nitrate nitrogen is maintained at about 92% andis far higher than the rate of release of the carbon source of a natural straw material, and secondary pollution to a water environment cannot be caused after long-term use of the ecological slow-release carbon source.

The invention provides a nanoparticle preparation method. According to the preparation method, a first microemulsion is mixed with a second microemulsion. The first microemulsion contains a surfactant, an organic solvent and a first reactant aqueous solution. The second microemulsion contains a surfactant, an organic solvent and a second reactant aqueous solution. Precipitates can be formed afterthe first reactant contacts with the second reactant. The surfactant in the first microemulsion is the same as that in the second microemulsion, and the surfactant is a mixture of an oil-soluble polyoxyethylene-polyoxypropylene segmented copolymer surfactant and a water-soluble polyoxyethylene-polyoxypropylene segmented copolymer surfactant or a cationic surfactant of cetyl trimethyl ammonium bromide and the like. The nanoparticles provided by the invention have good safety and can obviously raise gene transfection level and promote proteins or drugs to enter into cells.

The invention discloses a poly N-isopropyl acrylamide-sodium alginate double-layer coated temperature-sensitive slow-release nitrogen fertilizer. A method for preparing the poly N-isopropyl acrylamide-sodium alginate double-layer coated temperature-sensitive slow-release nitrogen fertilizer includes carrying out oxidation treatment on sodium alginate by the aid of sodium periodate to obtain oxidized sodium alginate; coating urea with the oxidized sodium alginate to obtain sodium alginate coated urea micro-spheres; synthesizing temperature-sensitive polymer poly N-isopropyl acrylamide microgel;carrying out fluidized bed spray granulation on the temperature-sensitive polymer poly N-isopropyl acrylamide microgel to obtain the poly N-isopropyl acrylamide-sodium alginate double-layer coated temperature-sensitive slow-release nitrogen fertilizer. The sodium periodate is used as an oxidizing agent. The oxidized sodium alginate is used as a base material. The temperature-sensitive polymer poly N-isopropyl acrylamide microgel is used as a temperature-sensitive envelope material. The poly N-isopropyl acrylamide-sodium alginate double-layer coated temperature-sensitive slow-release nitrogenfertilizer and the method have the advantages that temperature-sensitive polymers are led into the surfaces of the sodium alginate coated urea micro-spheres, accordingly, double-layer slow-release coating can be carried out on nitrogen fertilizers, effects of retaining the poly N-isopropyl acrylamide-sodium alginate double-layer coated temperature-sensitive slow-release nitrogen fertilizer can berealized, and loss and wastage of fertilizers can be reduced; aldehyde sodium alginate can be degraded without special conditions with specific enzymes and the like, and accordingly the problem of secondary pollution can be solved.

The invention discloses a carrageenan and gelatin microsphere embolization agent and a preparation method thereof. The carrageenan and gelatin microsphere embolization agent comprises mixed glue formed by carrageenan and gelatin, a biodegradable polymer, an emulsifier and a crosslinking agent. The carrageenan and gelatin microsphere embolization agent is a novel microsphere integrated with embolism and medicine administration functions, and can be applied to treatment of diseases such as tumors and the like. By adopting the preparation method of the microsphere, the novel microsphere, which has the advantages of wide grain diameter distribution range, large drug loading capacity, long embolization time, controllable in-vivo degradation time and the like can be prepared. The function of the existing microsphere is perfected, the carrageenan and gelatin microsphere embolization agent is prepared by using an emulsion crosslinking method, the carrageenan and gelatin microsphere embolization agent is simple in process, and convenient to operate, and good news is brought about for a patient.

The invention relates to an amphiphilic block copolymer micelle containing a lepidopteron sex pheromone, wherein one of a plutella xylostella sex pheromone, a prodenia litura sex pheromone and a beet armyworm sex pheromone is adopted as the lepidopteron sex pheromone. A waterborne block of an amphiphilic block copolymer comprises at least a polyethylene glycol (MPEG) series polymer unit, and a lipophilic block comprises at least a polycaprolactone (PCL) series polymer unit. MPEG-PCL has the good biocompatibility and the good medicine passing ability for small-molecule medicine, is high in medicine loading capacity and good in stability and is a biodegradable and environment-friendly material; in addition, the usage amount of organic solvent is little in the preparation process, so that environment pollution in the usage process is avoided; the lepidopteron sex pheromone is slowly released through pores in the wall, so that the effect of lasting and stable releasing is achieved.

The invention provides albumin hydrogel. The albumin hydrogel is prepared by mixing albumin, a cross-linking agent and a solvent, the cross-linking agent comprises a repeating unit having a structureof formula (I) and an end group having a structure of formula (II). The invention develops the albumin hydrogel which is rapid in crosslinking, low in gelatinization concentrating and free of biotoxicity, and the albumin hydrogel is applied to the fields of cell culture, tissue engineering and drug delivery. Besides, as a good paclitaxel topical treatment drug carrier, the albumin hydrogel overcomes the defect of poor paclitaxel solubility, polyoxyethylene castor oil with biotoxicity is not introduced, and compared with a systemic preparation, the albumin hydrogel has the advantages that the administration frequency is effectively reduced, the drug concentration at a tumor is increased, and the systemic toxicity is reduced. Nanoparticles wrapping paclitaxel are used as gel forming components of the gel, so that uniform distribution of the paclitaxel in the gel can be realized, and stable and continuous release is realized.

The invention relates to an implant and a preparation method thereof. The implant is prepared from components of raw materials in parts by weight as follows: 25-65 parts of a water-insoluble / micro-soluble medicine, 35-75 parts of a water-insoluble polymer and 0-10 parts of a release modifier. The preparation method of the implant comprises steps as follows: (1) the water-insoluble / micro-soluble medicine and the release modifier are dissolved in an organic solvent, and a water-insoluble / micro-soluble medicine solution is obtained; (2) the water-insoluble polymer and the water-insoluble / micro-soluble medicine solution obtained in the step (1) are mixed, the organic solvent is removed and a solid mixture is obtained; (3) the solid mixture obtained in the step (2) is put into a hot melt extruder to be extruded and cut, alternatively, the solid mixture in the step (2) is pressed and formed, and the implant is obtained. With the adoption of the preparation method of the implant, the phenomena of medicine crystallization or aggregation and degradation of the polymer can be effectively reduced or avoided, and long-term release of a medicine is facilitated.

An active intra-uterine device (IUD) is prepared from the basic material (low-density polyethene or silicon rubber) and the active substance chosen from steroid hormone contraceptive, Cu particles and copper oxide particles through proportional mixing and blow moulding.

The invention discloses a special organic fertilizer for organic oil tea. The special organic fertilizer is prepared from the following components in percentages by mass: 30-55% of compost, 5-15% of peat, 15-30% of potassium magnesium sulfate, 9-17% of powdered rock phosphate, 0.5-2% of borax, 0.5-1% of a seaweed extraction liquid and 5-15% of clay. The special organic fertilizer disclosed by the invention not only can provide crops with nutrients directly, but also can improve the cold resistance of the oil tea obviously, reduce the flower and fruit falling rates, reduce the plant diseases and insect pests and improve the stress resistance of plants, so that the crops bloom better and bear more fruits, a lot of nutrients are absorbed in a flowering and fruit-bearing later period, a purpose of bearing more fruits to promote production is achieved, the output of the oil tea is improved obviously, and a purpose of production and yield increase is achieved; moreover, the special organic fertilizer which can be used as a soil improver improves the organic matters of soil, regulates the pH value of the soil and improves the granular structures of the soil, and achieves the purposes of improving the soil and increasing the fertilizer efficiency.

The invention relates to a venlafaxine hydrochloride sustained-release capsule and a preparation method thereof, wherein the sustained-release capsule is composed of a sustained-release pillet and a capsule shell; the substrate of the sustained-release pillet is an inert pillet core; and a fluidized bed respectively comprises a medicine layer, an isolation layer and a sustained-release layer. Compared with the traditional rolling extrusion method, the preparation method disclosed by the invention is simple; and simultaneously, because of optimal selection of a coating layer, long-term release of medicines can be realized.

The invention belongs to the field of biological materials for dental healthcare, and relates to a root face protection material composition for dentistry. The root face protection material composition comprises a substrate material and a reinforcing material, wherein the substrate material comprises the following components in parts by weight: 1 to 10 parts of polymeric monomers, 1 to 20 parts ofadhesive additive, 0.01 to 10 parts of light initiator, and 50 to 99 parts of solvent; and the reinforcing material comprises the following components in parts by weight: 50 to 100 parts of polymericmonomers, 0.01 to 10 parts of light initiator, and 0 to 50 parts of inorganic filler. By adopting the root face protection material composition, a root face protection material has the following advantages: a) after the curing, people can take food immediately without worrying about the problems such as eating, tooth brushing and the like; b) the root face protection material is in a white or semi-transparent state, so that the attractive appearance of teeth is not influenced; and c) by adding a given amount of inorganic filler, the root face protection material has good strength and can remain on the tooth for a longer time.

The invention relates to a chewing gum comprising at least one biodegradable polymer, wherein the molecular weight of said polymer is at least 105000 g / mol (Mn). According to the invention, it has moreover been realized that this problem may be effectively dealt with by increasing the molecular weight of at least one of the biodegradable polymers in the chewing gum when compared to conventional chewing gum polymers and thereby increasing the robustness of the chewing gum with respect to softeners, emulsifiers and e.g. flavor.

The invention discloses a novel environmentally-friendly wood-plastic floor material and a preparation method thereof, and relates to the technical field of coatings. The material comprises, by weight, 15-25 parts of polyacrylic resin, 12-20 parts of polyamide resin, 20-35 parts of vegetable fibers, 8-13 parts of ceramic fibers, 5-12 parts of seashell powder, 7-15 parts of diatomaceous earth, 4-10parts of glass beads, 5-12 parts of expanded perlite, 10-18 parts of silica gel particles, 4-9 parts of nanometer titanium dioxide, 3-7 parts of nanometer magnesium oxide, 2-5 parts of nanometer molybdenum oxide, 2-5 parts of nanometer titanium nitride, 3-7 parts of peppermint essential oil, 4-7 parts of activated carbon, 5-10 parts of a plant regulator, 1.3-2.5 parts of a foaming agent, 2.4-3.8parts of a flame retardant, 1.4-2.6 parts of a plasticizer, 1.8-3.2 parts of an anti-aging agent and 30-45 parts of a 25 wt% ethanol solution. The material has the advantages of good aging resistance,no formaldehyde substances, greenness and environmental protection.

The invention relates to a konjac glucomannan aqua filter core and a preparation method therefor. The preparation method for the konjac glucomannan aqua filter core comprises the steps of preparing konjac fibers, preparing konjac glucomannan gel microspheres, preparing nutritional supplement containing konjac glucomannan gel microspheres and preparing the filter core. The konjac glucomannan aqua filter core disclosed by the invention adopts konjac as a main raw material and plays a role by using the adsorption performance of the konjac fibers and the konjac glucomannan gel microspheres and the sustained release performance of the microspheres. The konjac fibers can be used for purifying water, and the konjac glucomannan gel microspheres can be used for filtering out most microorganisms in the water, so that microbiocides are not required to be used to a large extent; and the nutritional supplement containing konjac glucomannan gel microspheres can enable nutrients to be released in a long-term, stable and continuous manner so as to guarantee human body absorption efficiency. A nutritional supplement contains the ingredients, i.e., calcium carbonate, ferrous fumarate, zinc sulfate, sodium selenite, copper sulfate, manganese sulfate, chromium picolinate and the like and can be used for supplementing human required essential trace elements such as calcium, ferrum, zinc, selenium, copper, manganese, chromium and the like.

The present invention discloses one kind of washing method with automatically controlled sterilization and the washing machine therewith. The washing machine includes one sterilizer comprising one container capable of being closed, one tray for the container to set on and one casing to holding the container and the tray and capable of being closed to form one integral. The sterilizer is set in the water supplying path of the washing machine, and inside the container is slow releasing functional composition for sterilizing. When water flows through, proper amount of functional composition is dissolved into water to sterilize and deodorize.

The invention provides an electret high-melt-index polypropylene master batch and a preparation method thereof. The electret high-melt-index polypropylene master batch is prepared from the following components in percentage by weight: 95%-99% of polypropylene powder; 0.3%-2% of di-tert-butyl peroxide; 0.1%-0.3% of a nucleating agent; 0.2%-1% of an antioxidant; 0.1%-0.5% of a lubricant; and 0.2%-1%of a dielectric medium. The preparation method comprises the following steps: mixing raw materials; feeding the mixed materials into an extruder; carrying out a vacuum de-volatilization treatment onthe materials in the extruder; cooling, molding, dicing; sieving, transferring, and drying. The problems of difficult dispersion, easy nozzle blockage, instability and easy drifting of a single polypropylene particle material can be solved; the electrostatic adsorption and negative ion sterilization capabilities of melt-blown cloth are improved, and droplets, dust, and viruses with a size less than microns are effectively blocked.

The invention discloses a composite phosphorus removal material based on collophanite and an application method of the composite phosphorus removal material. The composite phosphorus removal materialis a granular material prepared by taking collophanite, a material rich in active magnesium oxide and calcium sulfate as main raw materials. The obtained material is used as a filtering and percolating medium material for phosphorus removal, is used for deep phosphorus removal of phosphorus-rich water such as domestic sewage, black and odorous water bodies and farmland water, and has the advantages of wide raw material source, low material preparation cost and good phosphorus removal effect.

The invention discloses a preparation method of an anti-vascular calcification degradable drug-carrying coated scaffold. With a medical metal vascular scaffold as a base body, the surface of the vascular scaffold material is coated with a dissolution-erosion high-molecular material and an anti-vascular calcification medicine composite, and then the vascular scaffold is dried and sterilized to obtain the vascular scaffold having a calcium-phosphorus metabolism sustained medicine releasing coating. The anti-vascular calcification degradable drug-carrying coated scaffold has excellent capability of preventing and inhibiting vascular calcification, has curative effects of reducing complications of blood vessel atherosclerosis, and meanwhile effectively reduces potential risk of causing the vascular calcification by the degradable vascular scaffold.

The invention discloses polymer composite microspheres, and a preparation method and application thereof, and relates to the technical field of microsphere materials. The polymer composite microspheres comprise macromolecular compounds, albumin and protein binding type functional molecules, wherein the macromolecular compounds are used for coating the albumin and the protein binding type functional molecules. According to the preparation method of the polymer composite microspheres, the macromolecular compounds are used for coating the albumin and the protein binding type functional moleculesto form a microsphere structure, through the effects of the albumin and the effects of the protein binding type functional molecules, the effect of slowly releasing the protein binding type functionalmolecules for a long term can be achieved, and the sudden release effects of the protein binding type functional molecules can be alleviated. The polymer composite microspheres can be applied as slowrelease functional materials, and can be particularly used as drug bearing microsphere for slow release of drugs.

The invention discloses a heavy metal pollution stabilized repair material suitable for tailings and waste rock. The heavy metal pollution stabilized repair material includes an adhesive, a microbialcarrier material, facultative sulfate reducing bacteria, a sludge and straw mixture, sulfates and water. The obtained repair material has the function of slowly releasing a carbon source and sulfur elements through compounding of various materials, natural growth of microorganisms is fully used for continuously providing the microorganisms, reproduction growth of the original environment improvesthe environmental adaptability, formation of biofilms on the ore surface is accelerated, the cost is low, the service life is long, slowly releasing of the carbon source and the sulfur elements is achieved, and the control efficiency of heavy metals can be improved.

The invention provides crisaborole temperature-sensitive gel as well as a preparation method and application thereof. The crisaborole temperature-sensitive gel is prepared from the following raw material components in percentage by mass: 1 to 2 percent of crisaborole, 17 to 23 percent of poloxamer, 0.1 to 1 percent of modified cellulose, 5 to 15 percent of propylene glycol and / or glycerol, 5 to 10percent of ethanol, 0.01 to 0.02 percent of butylated hydroxytoluene and the balance of water. The crisaborole temperature-sensitive gel disclosed by the invention has the advantages that injection implantation and long-term drug release can be achieved; the drug can play a good slow-release effect in a human body by adopting a percutaneous drug delivery mode; in addition, drug extravasation canbe prevented and long-term drug release is achieved.

The invention discloses waterborne biomass negative oxygen ion paint. A formula of the waterborne biomass negative oxygen ion paint comprises the following raw materials by weight: 45-60 parts of a pure natural plant extract, 25-40 parts of a mineral extract, 25-40 parts of filler, 15-30 parts of a surfactant, 5-10 parts of a tackifier, 1-3 parts of an antifreeze agent, 1-3 parts of a dispersion agent, 0.8-1.2 parts of a film-forming agent, 0.4-0.8 part of a defoaming agent and 0.2-0.8 part of a mildew preventive. According to the waterborne biomass negative oxygen ion paint, an extracted pure natural plant, the rare mineral extract and the like are used as the raw materials, thus the comprehensive performance of the biomass paint is good, a wall is air-permeable, negative oxygen ions escape in an infrared radiation mode, and active time of solid molecules is long so that the negative oxygen ions can be released for a long time. The waterborne biomass negative oxygen ion paint is high in wear resistance capability, scratch-resistant, high-temperature-resistant, acid and alkali resistant, high in stability and long in service life, has functions of removal of harmful gas VOCs (volatile organic compounds), formaldehyde decomposition, air purification, health care and the like, does not contain formaldehyde, and is suitable for large-scale popularization.

The invention provides a photocatalyst coating material. The photocatalyst coating material comprises a sizing agent and a basic material, by weight, the sizing agent is mainly prepared by the following components of 40-50 parts of nano titania, 120-130 parts of titanium dioxide, 100-120 parts of nano silica flour, 30-40 parts of anion powder, 150-160 parts of extender pigment, 11-24 parts of sizing auxiliary agents and 230-250 parts of water; the basic material is mainly prepared by the following components of 260-280 parts of external wall emulsion and 44-74 parts of basic material auxiliary agent. The photocatalyst coating material and the preparation method thereof have five unique functions that 1, the ultra-low VOC and the excellent air purifying function are achieved, and formaldehyde, ammonia and benzene and other harmful gases in air can be purified; 2, the specific antibacterial and antifungal effects are achieved, and the antibacterial rate is above 98%; 3, anions can be released for a long time; 4. ultra-strong scrubbing resistance and aging resistance performances are achieved, and phenomena of pulverization, cracking and color fading and color changing are not prone to occurring; 5, the prominent protective capability is achieved, and fine cracks can be covered.

The invention provides a preparation method for refreshing and restoring preserved flowers. The preparation method comprises the following steps: immersing fresh sliced flowers in a decoloring and dewatering solution for 1-12 hours; and immersing the fresh sliced flowers into a microcapsule dispersing solution for 4-20 hours, and obtaining the refreshing and restoring preserved flower after drying. The microcapsule dispersing solution is prepared according to the following steps: uniformly dispersing 20-30 parts by weight of refreshing and restoring microcapsules in 80-150 parts by weight of waterborne polyurethane by a dispersing agent, and adding 0.5-1.5 parts by weight of a coloring material to obtain the microcapsule dispersing solution. Compared with the prior art, the preparation method disclosed by the invention has the advantages that the refreshing and restoring microcapsules are used as main components; as the microcapsules are excellent in slow release effect, essential oil can be continuously released for a long time; therefore, the preserved flowers have refreshing and restoring effects and also a slow release effect, are safe and effective, keep the beautiful appearance of a real flower and can beautify the environment.

The invention relates to the technical field of fertilizer processing, in particular to a preparation method of an elemental sulfur based ammonium phosphate slow release fertilizer. The preparation method comprises the following steps of preparation of sulfur sol, mixing, pelleting, coating and cleaning. The preparation method provided by the invention is simple in technology and safe to operate;a prepared coated elemental sulfur based ammonium phosphate product well controls the release rate of nitrogen, phosphorus and sulfur, realizes long-acting release of nutrient elements; and in addition, the contained sulfur and silicon components can promote absorption of other nutrient elements and improve the stress resistance growth of crops.