75results about How to "Increase molecular size" patented technology

The present invention provides antimicrobial solutions that in certain cases comprise a biguanide and a glycol ether and, in some cases, optionally also includes combinations of at least one an alcohol, at least one chelator, glycerol, deoxycholate, and / or at least one alkylpolyglucoside. In certain aspects the invention comprises a biguanide and deoxycholate or a combination of chelator, ethanol, and alkylpolyglucoside. Also provided are methods for rapidly killing and / or reducing bacteria, fungi, or virus from surfaces, for example, including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as medical equipment, pipelines etc.

The invention provides compositions containing hemoglobin, particularly PEGylated hemoglobin. The PEGylated hemoglobin molecule is capable of transferring oxygen or carbon monoxide bound thereto to a tissue with which it is in proximity. Exemplary PEGylated hemoglobin formulations of the invention are virally inactivated. Various compositions of the invention include deoxygenated hemoglobin, which may be conjugated with one or more water-soluble polymer. PEGylated hemoglobin includes those species in which the iron atom of the hemoglobin molecule is not bound to oxygen or any other species, and hemoglobin molecules in which a species other than oxygen, e.g., carbon monoxide, is bound to the iron atom. The compositions of the invention are formulated as hypo-, iso- or hypertonic solutions of the PEGylated hemoglobin. The compositions are of use to treat and / or ameliorate disease, injury and insult by providing for the oxygenation of tissues and / organs.

The invention relates to a chewing gum comprising at least one biodegradable polymer, wherein the molecular weight of said polymer is at least 105000 g / mol (Mn). According to the invention, it has moreover been realized that this problem may be effectively dealt with by increasing the molecular weight of at least one of the biodegradable polymers in the chewing gum when compared to conventional chewing gum polymers and thereby increasing the robustness of the chewing gum with respect to softeners, emulsifiers and e.g. flavor.

The invention discloses a silicon-containing polycarboxylate superplasticizer. The silicon-containing polycarboxylate superplasticizer is characterized by having a molecular structural formula (IV) as shown in the specification, wherein a and b are both greater than 0. C is greater than or equal to 0, and d is greater than 0; M1 is an organic silicon monomer structure of which the molecular structure contains a plurality of organic silicon molecules cross-linked by use of Si-O-Si bonds; M2 is one or both of -H and -Na; M3 is one or both of -H and -Na; M4 is one or both of ester monomers or ether monomers. According to the silicon-containing polycarboxylate superplasticizer, the organic silicon structure is introduced into the structure of the common polycarboxylate superplasticizer. A double-bond organic silicon monomer of a large molecular size is prepared by virtue of the hydrolysis reaction, and then the prepared organic silicon monomer is used in a polycarboxylate superplasticizer synthesis system, and therefore, the molecular size of the polycarboxylate superplasticizer is increased and then the polycarboxylate superplasticizer cannot come into the intercalation structure of soil easily, and furthermore, the effects of resisting soil and retarding consumption are achieved.

The present invention relates to a method for post-modification of a macroporous polymeric support comprising one or more unreacted double bonds, which method includes the steps of contacting the support with a liquid comprising a grafting compound; and initiating a free radical reaction in the mixture obtained, wherein the grafting compound is comprised of a double bond as a reactive group coupled to a linear or cyclic chain of carbon. The grafting compound can be illustrated with vinyl ethers and / or styrene and styrene derivatives.

This invention provides for a fusion protein between an IL2αβγ Selective Agonist protein (IL2 Selective Agonist) and a IgG Fc protein. The IL2 Selective Agonist moiety provides a therapeutic activity by selectively activating the IL2αβγ form of the receptor, thus selectively stimulating Tregs. The Fc moiety provides a prolonged circulating half-life compared to the circulating half-life of IL-2 or an IL2SA protein.

The invention provides compositions containing hemoglobin, particularly PEGylated hemoglobin. The PEGylated hemoglobin molecule is capable of transferring oxygen or carbon monoxide bound thereto to a tissue or red blood cells with which it is in proximity. Exemplary PEGylated hemoglobin formulations of the invention are virally inactivated. Various compositions of the invention include hemoglobin, which may be conjugated with one or more water-soluble polymer. PEGylated hemoglobin includes those species in which the iron atom of the hemoglobin molecule is not bound to oxygen or any other species, and hemoglobin molecules in which a species other than oxygen, e.g., carbon monoxide, is bound to the iron atom. The compositions of the invention are formulated as hypo-, iso- or hypertonic solutions of the PEGylated hemoglobin. The compositions are of use to treat and / or ameliorate disease, injury and insult by providing for the oxygenation of tissues and / organs.

The invention relates to a polysaccharide macromolecular paramagnetic metal complex and a synthesis method and an application thereof. Polysaccharide macromolecules are used as carriers, and a ligand compound, the side chains of which contain open-chain or annular polyamino polycarboxylic compounds, acts with paramagnetic metal ions to form the paramagnetic metal complex, wherein the paramagnetic metal ions are positive divalent or trivalent ions of metal elements, the atomic numbers of which are 21-29, 42 and 44 or 57-71. The polysaccharide macromolecular paramagnetic metal complex can be used as a magnetic resonance imaging contrast agent for lymphatic organs, lymphatic vessels, lymphatic systems and cardiovascular systems of people or other mammals.

The invention discloses a preparation method of a special slump retaining agent for cross-linked polycarboxylic acid. The preparation method comprises the following steps of step I, preparing a difunctional macromonomer: partially esterifying unsaturated polyether and unsaturated anhydride to generate a mixture A of the difunctional macromonomer, the unsaturated polyether and the unsaturated anhydride; step II, copolymerizing: polymerizing the mixture and unsaturated acid or unsaturated hydride small monomer B in the presence of a body polymerization initiator, adding sulfonic acid small monomer C and copolymerization adjusting agent to have the aqueous solution polymerization in the presence of an aqueous solution initiator to obtain a copolymerization product with mass concentration of 40 to 80 percent; step III, neutralizing: adjusting the pH value of the copolymerization product to be 6 to 7 to obtain special slump retaining agent for polycarboxylic acid. The invention also discloses a slump retaining agent prepared through the preparation method of the slump retaining agent for the cross-linked polycarboxylic acid. By introducing the difunctional macromonomer, an effect for preventing the slump loss can be realized.

This invention provides for a fusion protein between an IL2αβγ Selective Agonist protein (IL2 Selective Agonist) and a IgG Fc protein using a linker. The IL2 Selective Agonist moiety provides a therapeutic activity by selectively activating the IL2αβγ form of the receptor, thus selectively stimulating Tregs. The Fc moiety provides a prolonged circulating half-life compared to the circulating half-life of IL-2 or an IL2SA protein.

An assay comprises contacting cells containing a conformationally altered protein with test compound and determining if the altered protein is cleared. The cells may be scrapie-infected neuroblastoma cells. Another assay comprises contacting organ or tissue homogenate (at pH 5.0 or less) with test compound to determine if altered protein in the homogenate is 10 cleared. The homogenate may be brain homogenate from a transgenic mouse infected with human prions. Compounds which are found to clear the altered protein are useful in preventing, arresting and / or reversing (i.e. treating) a disease associated with the conformationally altered protein.

The invention discloses a preparation method of a high-solid-content ester polycarboxylic acid water reducing agent, which comprises the following steps: (1) mixing polyethyleneglycol monomethyl ether, amino-terminated polyoxypropylene ether, methacrylic acid, a catalyst and a mixed polymerization inhibitor to react to obtain a first mixture; (2) adding unsaturated carboxylate, a cationic monomer and a chain-transfer agent into 70-75 parts of the first mixture, and uniformly mixing to obtain a second mixture; mixing an initiator and acrylic acid to obtain a third mixture; dropwisely adding the third mixture and second mixture into 80-85 parts of the 45-80-DEG C first mixture within 1.5-2 hours, keeping the temperature at 45-80 DEG C to react for 1-1.5 hours, and after the reaction finishes, adding water to regulate the concentration of the system to 80-85%; and (3) adding sodium hydroxide into the material obtained in the step (2) for neutralization to obtain the high-solid-content ester polycarboxylic acid water reducing agent. The method has the advantages of high production efficiency and environment friendliness. The prepared product has excellent properties, and is convenient for storage and line haul.

The present invention relates to a method for post-modification of a macroporous polymeric support comprising one or more unreacted double bonds, which method includes the steps of contacting the support with a liquid comprising a grafting compound; and initiating a free radical reaction in the mixture obtained, wherein the grafting compound is comprised of a double bond as a reactive group coupled to a linear or cyclic chain of carbon. The grafting compound can be illustrated with vinyl ethers and / or styrene and styrene derivatives.

The present invention relates to new and improved interleukin-7 polypeptides, as well as compositions comprising the same, their preparation and uses. The invention more particularly relates to hyperglycosylated IL-7 polypeptides having improved properties, as well as their manufacture and therapeutic uses. The invention also discloses novel IL-7 polypeptides having modified amino acid sequences containing artificially created glycosylation site(s), as well as corresponding nucleic acid molecules, vectors and recombinant host cells. The invention also relates to the use of such polypeptides, cells or nucleic acids for curative or preventive treatment of mammalian subjects, including human subjects.

The invention provides a volume expansion type efficient slug gel plugging agent and a preparation method thereof. The volume expansion type efficient slug gel plugging agent is prepared from the following raw materials in parts by mass: 10-35 parts of a polymerization reaction agent, 1-3 parts of a cross-linking agent a, 0.02-0.5 part of a suitable-temperature initiator, 0.5-5 parts of a water-soluble resin flexibilizer, 0.5-5 parts of a composite inorganic flexibilizer, 2-8 parts of modified starch, 2-10 parts of a volume expansion reaction agent and 2-8 parts of a rheological modifier, wherein the volume expansion reaction agent is prepared from the following raw materials through an inverse emulsion polymerization method: a water-soluble polymeric monomer, a dispersion medium, an emulsifier, an oil-phase initiator and a cross-linking agent b. The plugging agent disclosed by the invention has the advantages of capability of underground crosslinking gel forming, flexible and adjustable gel forming time, high pressure bearing capacity after gel forming, relatively high water absorption expansibility, excellent mechanical strength after water absorption and the like.

The present invention provides a class of biochemically-activated MRI contrast agents. The agents include a paramagnetic chelate attached via a linker arm to a relaxivity-modulating group. When the relaxivity-modulating group is removed or otherwise interacts with a targeted substance, the agents are activated by various mechanisms. The activation is detectable by an increase or decrease in the relaxivity of the metal chelate. The agents are useful in the detection of biochemical parameters in cells, tissues and subjects. Exemplary biochemical parameters are markers that are associated with disease states.

The invention discloses a preparation method of a polycarboxylic acid water reducing agent with low sensitivity on mud content of concrete. A silane group is introduced into a polycarboxylic acid molecular structure, the silane group and cement granules can form chemical bonding, the molecular size is increased, the polycarboxylic acid is prevented from being adsorbed by the mud with an intercalated structure, the adaptability problem of the polycarboxylic acid and the cement is improved, and the sensitivity on the change of the mud content can be reduced; and a polyether ester structure is introduced in the polycarboxylic acid molecular structure, so that the shape and the branched structure of the long side chain of the polycarboxylic acid in a concrete multi-phase system can be improved, the side chain is extended and relax, the peaceability of the concrete is improved and the sensitivity on the change of the mud content is reduced.

The invention discloses a collagen-inorganic metal salt flocculating agent and a preparation method thereof. The preparation method comprises the following steps of: adding electrolysis collagen in water, stirring and dissolving, heating a cross-linking agent dissolved in water, stirring and reacting, and cooling to obtain cross-linked collagen; and adding an inorganic metal salt in the cross-linked collagen, regulating pH, and stirring and reacting to obtain the collagen-inorganic metal salt flocculating agent. The flocculating agent is viscous liquid or powder which is lightly yellow in color and appearance and is free from smell, relative molecular weight distribution of the cross-linked collagen is 8000-68000Da, and flocculating efficiency of kaolin is 0.8472-0.9536. The preparation method disclosed by the invention, on the basis of cross linking electrolysis collagen which is low in molecular weight through the cross-linking agent and compositing the inorganic metal salt, not only improves flocculating efficiency, but also reduces use cost; and the preparation method is simple and easy to prepare, strong in operability, and easy to industrially produce.

The invention relates to a composite catalyst for preparing aromatic polycarbonate and application of the composite catalyst. The composite catalyst contains the following raw material components: an organic alkali catalyst and an alkali ionic liquid. The composite catalyst is used in the preparation process of the aromatic polycarbonate, namely, by taking a dihydroxyl compound and dialkyl carbonate as raw materials, synthesizing polycarbonate by using a non-phosgene ester interchange method, wherein the mole ratio of the dihydroxyl compound to the dialkyl carbonate is 1:(1.015-1.1); and the amount of the composite catalyst accounts for 0.5-5% of the mass of the dihydroxyl compound. By adopting the composite catalyst provided by the invention, not only is ester exchange reaction in the polycarbonate synthesis process implemented at a relatively high speed at relatively low temperature, but also the residual amount of the catalyst in a polymerization product is reduced to the minimum extent; and in addition, special properties of a polymeric product are achieved, and meanwhile, adverse influence of application properties of the product, namely the polycarbonate, is avoided to the maximum extent.

The invention provides a diamino polyethylene glycol modified paramagnetic metal complex magnetic resonance imaging contrast agent, and aims at solving the problems of low relaxation rate, high toxicity and large dosage of a contrast agent in the prior art. The contrast agent is prepared by the following steps: reacting 1,4,7,10-tetrazacyclododecane-1,4,7,10-tetraacetic acid compound with diaminopolyethylene glycol with different molecular weights; preparing a macromolecular ligand through an amidation reaction; and forming a paramagnetic metal complex with paramagnetic metal elements Sc, Ti, V, Mn, Cu, Mo, Ru, Fe or positive trivalent or divalent ion of lanthanide rare-earth elements. The contrast agent has the advantages of high stability, water solubility, relaxation rate and small dosage.

The invention discloses a preparation method of a mud content low-sensitive type polycarboxylic acid superplasticizer. According to the preparation method disclosed by the invention, a silane group isintroduced into a polycarboxylic acid molecular structure and can be chemically bonded with cement grains; meanwhile, the molecule size is easy to increase, a condition that polycarboxylic acid is adsorbed by mud with an intercalated structure is avoided and the adaptability problem between the polycarboxylic acid and cement is improved; the sensitivity on mud content changes can be reduced; a polybasic ether ester structure is introduced into the polycarboxylic acid molecular structure so that a shape and a branched structure of a polycarboxylic acid long side chain in a concrete multi-phasesystem can be improved, and the side chain is stretched and loosened better; the workability of concrete is improved and the sensitivity on the mud content changes is reduced.

Provided are: a soluble polyfunctional vinyl aromatic copolymer improved in heat resistance, thermal decomposition resistance, solubility in solvents, processability and compatibility with specific resins; and a curable resin composition containing the copolymer. A terminal-modified soluble polyfunctional vinyl aromatic copolymer which is a copolymer produced by polymerizing a divinyl aromatic compound (a), a monovinyl aromatic compound (b) and a (meth)acrylic acid ester compound (c) in the presence of at least one catalyst (d) selected from the group consisting of a Lewis acid catalyst, an inorganic strong acid and an organic sulfonic acid and which has a terminal group derived from the (meth)acrylic acid ester compound (c) at some of the terminals of the copolymer.

A process modifies the surface diffusion and wetting characteristics of a microporous material such as active carbon or silica, by applying a plasma of polymer precursor monomers to an external surface of the material to modify its adsorption properties, the microporous material obtainable thereby being modified by presence of a nanolayer of polymeric material extending over said external surface around the pores to partially occlude pore openings to a predetermined extent, but the nanolayer does not substantially infiltrate the pores of the microporous material.

The present invention relates to novel derivatives of human glucagon-like peptide-2 (GLP-2) peptides, which have a protracted profile of action, as well as pharmaceutical compositions, uses and methods of treatment.

The invention provides compositions containing hemoglobin, particularly PEGylated hemoglobin. The PEGylated hemoglobin molecule is capable of transferring oxygen or carbon monoxide bound thereto to a tissue with which it is in proximity. Exemplary PEGylated hemoglobin formulations of the invention are virally inactivated. Various compositions of the invention include hemoglobin, which may be conjugated with one or more water-soluble polymer. PEGylated hemoglobin includes those species in which the iron atom of the hemoglobin molecule is not bound to oxygen or any other species, and hemoglobin molecules in which a species other than oxygen, e.g., carbon monoxide, is bound to the iron atom. The compositions of the invention are formulated as hypo-, iso- or hypertonic solutions of the PEGylated hemoglobin. The compositions are of use to treat and / or ameliorate disease, injury and insult by providing for the oxygenation of tissues and / organs.

The invention relates to a novel environment-friendly composite gold ore dressing collector. The novel environment-friendly composite gold ore dressing collector comprises, by weight, the following components: 35-45 parts of a main collector, 20-35 parts of an auxiliary collector and 15-20 parts of water; wherein the main collector comprises, by weight, the following raw materials: 45-50 parts ofdihydrocarbyl dithiophosphate, 20-28 parts of isooctyl thioglycolate, 8-12 parts of thiourethane, 5-9 parts of sodium oleate and 8-10 parts of dihydrocarbyl thiocarbonyl carbamate; the auxiliary collector comprises, by weight, the following raw materials: 30-35 parts of alkyl hydroxamic acid, 26-28 parts of polyacrylamide and 10-15 parts of isooctanol phosphate. The novel environment-friendly composite gold ore dressing collector has the advantages of strong collecting capacity, good selectivity, small dosage and foaming property for gold ore, and effectively solves the problems that the ore dressing recovery rate of fine grains and micro fine grains is low, the fine-grained gold is easy to lose when gold with high sulfur content is separated, and the gold-sulfur separation recovery rate is low.

The invention relates to the technical field of rubber, specifically to a high-strength copolymerized fluorinated silicone rubber composition and a preparation method thereof. The fluorosilicone rubber composition comprises, in parts by weight, 100 parts of raw copolymerized fluorinated silicone rubber, 30 to 70 parts of fumed silica, 4 to 12 parts of hydroxyl fluorosilicone oil with a viscosityof 90 to 120 mPa.s (at 25 DEG C), 0 to 10 parts of high-vinyl fluorosilicone oil, 1 to 2 parts of 2,5-dimethyl-2,5-di(tert-butylperoxy)hexane and 0 to 2 parts of pigment, wherein the side chain of a polymer chain of the raw copolymerized fluorinated silicone rubber contains trifluoropropyl polyhedral oligomeric silsesquioxane. The high-strength copolymerized fluorinated silicone rubber compositiondisclosed by the invention has better mechanical strength and improved high-temperature resistance after being vulcanized; and the fuel oil resistance of the composition can be obviously improved byintroducing a small amount of trifluoropropyl polyhedral oligomeric silsesquioxane, and the comprehensive performance of the composition is better.