31results about How to "Convenient IV" patented technology

The invention discloses an experimental visual rat tail vein fixator comprising a base, wherein the base is provided with a fixed block and a regulating rod; one end of the regulating rod is movably connected with the fixed block or base, and the other end of the regulating rod is provided with a tail supporting frame; the distance between the tail supporting frame and the fixed block can be regulated through regulating the regulating rod; the top of the tail supporting frame is provided with a chute; a horizontally-irradiating yellow fluorescent lamp is embedded in the side wall of the chute; the fixed block is provided with a first fixed groove; the fixed block is provided with a pressing block which can be opened or closed relative to the fixed block so as to press or release a rat tail. The experimental visual rat tail vein fixator also has the advantages of simple and compact structure, low manufacturing cost as well as simplicity and convenience in use.

A contrast medium for the magnetic resonance (or X-ray CT) imaging of liver with high selectivity and low poison is prepared from the acid byanhydride of EDTA and DTPA and russianolive gum through reaction and then matching with the 2- or 3- valence ions of paramagnetic metal (Mn or Fe) or La- system RE element to obtain a russianolive gum modified paramagnetic metal match.

The invention discloses a mouse tail vein injection fixing tube, which comprises a base, a bracket, a fixing platform and a fixing tube body, the top of the base is fixedly connected with the bottom of the bracket by bolts, and the top of the bracket is provided with a The fixed table top, the fixed pipe body is placed on one side of the top of the fixed table, wherein, one side of the fixed pipe body is provided with a pipe cover, and the pipe cover is set in a threaded structure together with the fixed pipe body The side is fixedly connected, the middle part of the tube cover is provided with through hole 1, and the bottom of the fixed tube body is provided with several through holes 2, and the fixed tube body is fixedly connected with one side of the fixed table through several adhesive tapes , several fixing columns are arranged on the other side of the top of the fixing platform and on the side away from the fixing tube body. Beneficial effects: the work efficiency is improved, the operation is convenient, and the reservation and adjustment of the fixed position of the mouse tail are greatly facilitated.

The invention relates to a magnetic resonance image contrast agent which uses arabinogalactan as carrier, wherein its production comprises that: using ethylenediamine tetra acetic acid, diethylene triamine pentacetic acid N-butanimide active ester, ethylenediamine tetra acetic acid, or the anhydrides of diethylene triamine pentacetic, via one short connecting arm to react with amination arabinogalactan; forming amido bond to connect ethylenediamine tetra acetic acid or diethylene triamine pentacetic acid to the arabinogalactan, to match magnetic metal ion as manganese, iron or lanthanide rare-earth element, to obtain complex. The invention has significant liver selectivity and low cute toxin. And the inventive contrast agent can be used in magnetic resonance diagnosis, X-ray CT or Y-flashimaging diagnosis.

The invention provides a diamino polyethylene glycol modified paramagnetic metal complex magnetic resonance imaging contrast agent, and aims at solving the problems of low relaxation rate, high toxicity and large dosage of a contrast agent in the prior art. The contrast agent is prepared by the following steps: reacting 1,4,7,10-tetrazacyclododecane-1,4,7,10-tetraacetic acid compound with diaminopolyethylene glycol with different molecular weights; preparing a macromolecular ligand through an amidation reaction; and forming a paramagnetic metal complex with paramagnetic metal elements Sc, Ti, V, Mn, Cu, Mo, Ru, Fe or positive trivalent or divalent ion of lanthanide rare-earth elements. The contrast agent has the advantages of high stability, water solubility, relaxation rate and small dosage.

The invention discloses an operation table for tail vein injection of mice in batches, which includes a work table and 3-8 operation units, and the operation unit includes a rotating shaft one, a rotating arm one, a rotating shaft two, a rotating arm two, and a rotating shaft 3. The mouse fixing device and heating switch, the first rotating arm can rotate 360 ​​degrees along the horizontal plane and 180 degrees along the vertical plane, the second rotating arm can rotate 180 degrees along the vertical plane, the mouse fixing device can rotate 180 degrees along the vertical plane, The mouse fixing device is provided with a heating device and a heat-conducting material, and also includes a control circuit, and the control circuit controls the opening or closing of the heating device through a heating switch. The mouse fixing device includes a base plate and a mouse cage. By setting a long groove on the base plate and covering the mouse body in the mouse cage, the tail of the mouse is exposed, and a pressing plate and a fixing belt are set to completely secure the tail of the mouse. fix it up. The console has a simple structure and is easy to operate, and the mice are immobilized and injected in batches to form an assembly line operation and improve efficiency.

The invention relates to a palonosetron hydrochloride injection and a preparation method thereof. The palonosetron hydrochloride injection is characterized by comprising palonosetron and an osmotic pressure regulator. The preparation is simple in formulation and process, and the quality is stable and easy to control; moreover, the preparation can be applied to direct intravenous drip administration; clinical application is convenient, administration compliance is high, and the safety is high.

The invention relates to a paramagnetic metal complex modified by an aspartic acid-leucine copolymer as well as a preparation method and an application of the paramagnetic metal complex, and is used for solving the technical problems of low biodegradability, low liver targeting property, immunity defects and the like of the existing liver-type macromolecular contrast agent. The paramagnetic metal complex is formed by taking the aspartic acid-leucine copolymer as a carrier, wherein annular 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid ligands are connected on side chains of the carrier. A magnetic resonance imaging contrast agent prepared from the paramagnetic metal complex provided by the invention has the characteristics of a corresponding polyamine multi-carboxy complex, so that the magnetic resonance imaging contrast agent is good in stability, water solubility and relaxation rate, and simultaneously has the targeting property to the liver so as to realize the targeted imaging to improve the imaging contrast ratio and the imaging definition. Thus, the magnetic resonance imaging contrast agent has a good effect for improving the early-stage diagnosis level of diseases of the liver organs.

A tail vein injection method for mice, involving an injection method, the tightening bolt (24) is screwed counterclockwise, the clamping of the U-shaped splint (12) is loosened, and the device (1) is rotated clockwise by hand to make the device ( 1) In a vertically placed state, turn the tightening bolt (24) clockwise to clamp and fasten the U-shaped splint (12) and the vertical plate (23), and fix the position of the device (1); the invention discloses A mouse tail vein injection method was developed. During the pharmacological experiment, it can realize the immobilization of mice that meet different specifications and body weights, and the integration of mouse placement and injection process. The body weight is limited and the mouse needs to be "stuck" for the inconvenience of filling. The invention is convenient to operate and optimizes the mouse filling method and the tail vein injection operation of the mouse.

The invention relates to a simple mouse experiment auxiliary device operation method which is characterized in that a mouse intravenous injection device is provided and comprises a base and a transparent hemispherical cover. The method includes the steps: S01, rotating limit screws, and adjusting a limit screen to highest position; S02, opening the transparent hemispherical cover, and placing a mouse on the circular base; S03, covering the transparent hemispherical cover, adjusting position of a mouse tail clamp on a rail, and clamping a mouse tail; S04, pressing downwards the limit screen, adjusting the limit screws after a mouse is fixed, and performing positioning for the limit screen; S05, spraying ethyl alcohol to sterilize. According to the method, the mouse experiment auxiliary device can be skillfully operated by users, and subsequent mouse intravenous injection efficiency is ensured.

A three-dimensional positioning fixing frame for a hillock hemorrhage biological experiment effectively solves the problem that a mouse absorbs medicine slowly after the mouse is injected with the medicine and comprises a box body, a bottom plate is fixedly connected to the interior of the box body, a rotating shell is arranged on the upper side of the bottom plate, an operation plate is arranged in the rotating shell, and a power rod is arranged on the upper side of the bottom plate. A rotating frame is arranged on the lower side of the power rod, a driving plate is arranged on the left side of the rotating frame, a first runway cavity is formed in the left side of a rotating shell, a second runway cavity is formed in the right side of the rotating shell, a cover plate is arranged on the upper side of the rotating shell, first fixing plates are fixedly connected to the front side and the rear side of the rotating shell, and second fixing plates are arranged on the front side and the rear side of the rotating shell. By means of the design, the function of driving an experimental mouse to move so as to accelerate blood circulation is effectively added, the purposes of fixing the mouse and conducting intravenous injection on the tail are achieved, and the problem that an experimental site is not easy to clean after an experiment is conducted is solved.

The invention provides a core-shell gold nano-particle capable of intensifying the photo-thermal transformation effect. The novel core-shell structure gold nano-particle is composed by using gold as a shell and medicines as a core and loading acid radical medicines in the hollow structure of the hollow gold nano-particle, and is absorbed by a characteristic peak in a near infrared region with the wavelength of 700-900nm, wherein the particle diameter is 30-200nm. In the photo-thermal action, the structure of the gold nano-particle becomes loose to trigger release of medicines and play the effect of chemotherapy. The core-shell gold nano-particle shows an intensified photo-thermal transformation capability under near infrared light (wavelength of 700-900nm) radiation to generate a thermal-therapy effect on a tumor site, and can generate double effects of thermal therapy and chemo therapy; and the two treatment modes synergetically act, and are conductive to killing tumor cells comprehensively and completely. The core-shell gold nano-particle is capable of remarkably improving the effect for treating tumors, and can be applied to preparation of tumor treatment medicaments.

An injection of water-soluble 17-allylamino-17-demethoxy geldanamycin (17-AAG) for treating multiple kinds of cancers is prepared from 17-AAG and polyethanediol for increasing the solubility of 17-AAG in water.

The invention provides a Ce6 derivative, its nano-preparation, its preparation method and application. The Ce6 derivative, which is named TCe6, has a structural formula as shown in the following formula. In the present invention, TCe6 and CHC are co-assembled to construct TCe6 / CHC NPs, which solves the problems of insufficient oxygen and low efficiency in PDT, and realizes efficient photodynamic therapy. .

The invention discloses an experimental visual rat tail vein fixator comprising a base, wherein the base is provided with a fixed block and a regulating rod; one end of the regulating rod is movably connected with the fixed block or base, and the other end of the regulating rod is provided with a tail supporting frame; the distance between the tail supporting frame and the fixed block can be regulated through regulating the regulating rod; the top of the tail supporting frame is provided with a chute; a horizontally-irradiating yellow fluorescent lamp is embedded in the side wall of the chute; the fixed block is provided with a first fixed groove; the fixed block is provided with a pressing block which can be opened or closed relative to the fixed block so as to press or release a rat tail. The experimental visual rat tail vein fixator also has the advantages of simple and compact structure, low manufacturing cost as well as simplicity and convenience in use.

The invention provides a paramagnetism metal complex magnetic resonance imaging contrast agent containing asparaginic acid-glucan and a preparation method of the contrast agent, to solve the problem that in the prior art the contrast agent is low in relaxation rate. According to the contrast agent, the glucan is used as a carrier; asparaginic acid is connected with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and is further subjected to coordination with the paramagnetism metal ions in a mole ratio of 1:1 so as to obtain the complex. According to the preparation method of the paramagnetism metal complex magnetic resonance imaging contrast agent containing the asparaginic acid-glucan, the contrast agent with relatively higher relaxation efficiency is obtained by controlling the dosage ratio of reaction raw materials, the pH value of solution, the reaction temperature and the reaction time. The contrast agent can be used for magnetic resonance imaging; after the contrast agent imaging is accomplished, the asparaginic acid carried in the contrast agent has protection function on hearts, and therefore the contrast agent is an imaging contrast agent with double functions.

A contrast medium for the magnetic resonance (or X-ray CT) imaging of liver with high selectivity and low poison is prepared from the acid byanhydride of EDTA and DTPA and russianolive gum through reaction and then matching with the 2- or 3- valence ions of paramagnetic metal (Mn or Fe) or La- system RE element to obtain a russianolive gum modified paramagnetic metal match.

The invention relates to an anti-tumor and thrombolytic dual-effect chimeric protein with low immunogenicity, its preparation method and application. The amino acid sequence of the chimeric protein is as shown in SEQ ID NO.11 or SEQ ID NO.12. The chimeric protein of the invention makes staphylokinase delta Sak with 10 amino acids deleted on the N end and staphylococcal enterotoxins delta SEC2 with 10 and 132 amino acids deleted respectively on the N and the C end jogged together, and keeps no connecting peptide between the two. The constructed chimeric proteins delta SEC2-delta Sak and delta Sak-delta SEC2 have substantially reduced molecular weights, and amino acid sequences with high immunogenicity are removed, so that the problems of large molecular weight and high immunogenicity of chimeric proteins are solved. Meanwhile, the anti-tumor and thrombolytic functions are retained.

The invention provides a paramagnetic metal complex and a synthetic method and application thereof. The paramagnetic metal complex is an arabinogalactan-modified 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacethyl paramagnetic metal complex. A magnetic resonance imaging contrast agent prepared from the paramagnetic metal complex has high stability, water solubility and relaxation rate and is targeted to liver and kidney, so that targeted imaging is realized, and the imaging contrast and definition are improved. The paramagnetic metal complex has a good effect on raising the early diagnosis levels of diseases of liver and kidney organs, is about 2 times the relaxation rate of dotarem, has very long targeted radiography imaging time, can be easily prepared into a solution with required concentration for intravenous injection, is suitable for sterilizing and disinfecting with a hot pressing method, can be selectively identified by an asialoglycoprotein receptor on a liver parenchyma surface, and has high selectivity on livers of human beings or other mammals.