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Paramagnetic metal coordination compound magnetic resonance imaging contrast medium with narrow-leaved oleaster polyose modification

A paramagnetic metal and magnetic resonance imaging technology, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo experiments, pharmaceutical formulations, etc. The effect is not ideal, etc., to achieve good water solubility, improve imaging contrast, and good selectivity

Inactive Publication Date: 2008-11-12
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They have good imaging effects on the brain and central nervous system, etc., but their extracellular distribution and rapid renal metabolism limit their application, especially for some organs in the body such as liver and kidney. Requirements for tissue and organ selectivity

Method used

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  • Paramagnetic metal coordination compound magnetic resonance imaging contrast medium with narrow-leaved oleaster polyose modification
  • Paramagnetic metal coordination compound magnetic resonance imaging contrast medium with narrow-leaved oleaster polyose modification
  • Paramagnetic metal coordination compound magnetic resonance imaging contrast medium with narrow-leaved oleaster polyose modification

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Preparation of gadolinium ethylenediaminetetraacetic acid (Gd-EDTA) complexes modified with 100,000 molecular weight (100kDa) polysaccharides of Elaeagnus japonicus

[0046] (1) Preparation of ethylenediaminetetraacetic acid bis-anhydride: 36.0g of ethylenediaminetetraacetic acid (EDTA) was stirred and reacted at 64±2°C for 10 hours in 100mL of acetic anhydride and 80mL of anhydrous pyridine solution. Suction filter, wash with acetic anhydride, then with anhydrous ether, and vacuum-dry at 50°C to obtain 31.0 g of yellowish solid EDTA anhydride.

[0047] (2) Preparation of ethylenediaminetetraacetic acid modified with 100,000 molecular weight (100kDa) Elaeagnus polysaccharide: Dissolve 0.60g of EDTA anhydride in 1.00g of 100,000 molecular weight (100kDa) Elaeoptera polysaccharide in 80mL of anhydrous DMSO solution, After stirring at room temperature for 24 hours, cool in an ice-water bath, slowly add distilled water, continue to stir for 12 hours, dialyze deionized water...

Embodiment 2

[0050] Preparation of manganese ethylenediamine tetraacetate (Mn-EDTA) complexes modified with 100,000 molecular weight (100kDa) polysaccharide

[0051] (1) Preparation of ethylenediaminetetraacetic acid bis-anhydride: 36.0g of ethylenediaminetetraacetic acid (EDTA) was stirred and reacted at 64±2°C for 10 hours in 100mL of acetic anhydride and 80mL of anhydrous pyridine solution. Suction filter, wash with acetic anhydride, then with anhydrous ether, and vacuum-dry at 50°C to obtain 31.0 g of yellowish solid EDTA anhydride.

[0052] (2) Preparation of ethylenediaminetetraacetic acid modified with 100,000 molecular weight (100kDa) Elaeagnus polysaccharide: Dissolve 0.60g of EDTA anhydride in 1.00g of 100,000 molecular weight (100kDa) Elaeoptera polysaccharide in 80mL of anhydrous DMSO solution, After stirring at room temperature for 24 hours, cool in an ice-water bath, slowly add distilled water, continue to stir for 12 hours, dialyze deionized water for 5 days, change the wate...

Embodiment 3

[0055] Preparation of gadolinium diethylenetriaminepentaacetate (Gd-DTPA) complex modified with 200,000 molecular weight (200kDa) polysaccharide

[0056] (1) Preparation of diethylenetriaminepentaacetic acid bis-anhydride: put 59.0g of DTPA, 70mL of acetic anhydride and about 100mL of anhydrous pyridine into a 250mL round-bottomed flask with a condensing device at the mouth of the flask, and control the temperature at 64±2°C for 24 Hour. Suction-filtered brown-yellow insoluble matter was washed with acetic anhydride and then with anhydrous ether, and vacuum-dried at 50°C to obtain 46 g of yellowish solid DTPA anhydride.

[0057] (2) Preparation of diethylenetriaminepentaacetic acid modified with 200,000 molecular weight (200kDa) polysaccharide of Eleuthero jujube gum: Dissolve 0.70g of DTPA anhydride in 100mL of anhydrous DMSO solution of 1.00g of 200,000 molecular weight (200kDa) of polysaccharide of Elsewhere polysaccharide , after stirring at room temperature for 24 hours,...

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Abstract

A contrast medium for the magnetic resonance (or X-ray CT) imaging of liver with high selectivity and low poison is prepared from the acid byanhydride of EDTA and DTPA and russianolive gum through reaction and then matching with the 2- or 3- valence ions of paramagnetic metal (Mn or Fe) or La- system RE element to obtain a russianolive gum modified paramagnetic metal match.

Description

technical field [0001] The invention relates to a contrast agent for magnetic resonance imaging, in particular to a contrast agent for magnetic resonance imaging of paramagnetic metal complexes modified by polysaccharides of Elaeagnus japonicum. Background technique [0002] Magnetic resonance imaging (MRI) is currently the most advanced medical imaging diagnostic technology. Compared with X-ray CT scanning, this technology has the advantages of high resolution, multiple imaging parameters, slices at any level, and no ionizing radiation damage to the human body. The MRI signal intensity of human tissue mainly depends on the proton density N(H) and relaxation properties of the tissue, including the longitudinal relaxation time T 1 and the transverse relaxation time T 2 , when the proton density of a specific tissue is constant, the length of the proton relaxation time determines the signal intensity of the tissue. [0003] In clinical magnetic resonance imaging, more than ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61K49/12
Inventor 裴奉奎孙国英李中峰李晓晶苏为平李伟生
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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