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45results about How to "Less soluble" patented technology

Insulin formulations for insulin release as a function of tissue glucose levels

Injectable insulin formulations that are capable of modifying the amount of insulin released based on the patient's tissue glucose levels, methods for making and using these formulations are described herein. The formulation may be administered via subcutaneous, intradermal or intramuscular administration. In one preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin, an oxidizing agent or enzyme and a reducing agent or enzyme, a diluent and optionally one or more thickening agents. If a thickening agent is present in the formulation, the thickening agent increases the viscosity of the formulation following administration. Preferably the formulation contains an insulin, a diluent, glucose oxidase and peroxidase. Following administration to a patient, the insulin is released from the formulations as a function of the patient's tissue glucose level, which in turn maintains the patient's blood glucose level within an optimum range. The formulation is often referred to as a “smart” formulation since it modifies its release rate of insulin according to the patient's needs at a particular time. In a preferred embodiment, the formulation is designed to release insulin into the systemic circulation over time with a basal release profile following injection in a patient. In another embodiment, the formulation is designed to release insulin into the systemic circulation over time with a non-basal release profile following injection in a patient, such as a regular human insulin release profile or a prandial release profile.
Owner:BIODEL

Integrated fixation systems

InactiveUS6838504B1Barrier to the leaching of environmentally harmful heavy metalsLess solublePrimary cell maintainance/servicingEnergy based wastewater treatmentPhosphatePVA - Polyvinyl alcohol
The invention provides polymeric matrices and films comprising fixation reagents that are capable of reacting with solubilized metals to form less soluble metal compounds. The fixation reagenst may include inorganic sulfides and phosphates, as well as adsorbents. The polymeric matrices may be comprised of polyvinyl alcohols and polyvinyl acetates. In some embodiments, the polymeric matrix is selected to be at least as soluble as the selected fixation reagent, particularly under the conditions in which the matrix is expected to come into contact with the solublized metal.
Owner:GEMINI STRATEGIES +2

Catalysts

ActiveUS20050245623A1Good resultFacilitates the eventual dislodging and washingLiquid hydrocarbon mixture productionHydrocarbon oils refiningChemistryCobalt
A process for preparing a cobalt-based Fischer-Tropsch synthesis catalyst includes introducing a soluble modifying component precursor of the formula Mc(OR)x, where Mc is a modifying component selected from the group comprising Si, Ti, Cu, Zn, Zr, Mn, Ba, Ni, Na, K, Ca, Sn, Cr, Fe, Li, Tl, Sr, Ga, Sb, V, Hf, Th, Ce, Ge, U, Nb, Ta, W or La, R is an alkyl or acyl group, and x is an integer having a value of from 1 to 5, onto and / or into a cobalt-based Fischer-Tropsch synthesis catalyst precursor, which comprises a porous pre-shaped catalyst support supporting cobalt in an oxidized form. The resultant modified cobalt-based Fischer-Tropsch synthesis catalyst precursor is reduced to obtain a cobalt-based Fischer-Tropsch synthesis catalyst.
Owner:SASOL TEKHNOLODZHI PROPRIEHJTEHRI LTD

Ionic Liquids Based on Imidazolium Salts Incorporating a Nitrile Functionality

Novel chemical compounds of the general formula
K+A,
in which K+is a 5- or 6-membered heterocyclic ring having 1-3 hetereo atoms, which can be independently N, S, or O;
with the proviso that at least one of the hetereo atoms must be a quaternized nitrogen atom having a —R′CN substituent, wherein R′ is alkyl (C1 to C12);
the heterocyclic ring having up to 4 or 5 substituents independently chosen from the moieties:
(i) H;
(ii) halogen or
(iii) alkyl (C1 to C12), which is unsubstituted or partially or fully substituted by further groups, preferably F, Cl, N(CnF(2n+1−x)Hx)2, O(CnF(2n+1−x)Hx), SO2(CnF(2n+1−x)Hx)2 or CnF(2n+1−x)Hx where 1<n<6 and 0<x<13; and
(iv) a phenyl ring which is unsubstituted or partially or fully substituted by further groups, preferably F, Cl, N(CnF(2n+1−x)Hx)2, O(CnF(2n+1−X)Hx), SO2(CnF(2n+1−x)Hx)2 or CnF(2n+1−x)Hx where 1<n<6 and 0<x≦13; and
Ais any anion that provides a salt with a low melting point, below about 100° C.; A can be halide, BF4−, PF6, NO3, CH3CO2, CF3SO3, (CF3SO2)2N, (CF3SO2)3C, CF3CO2 or N(CN)2 or [BF3RCN]
These compounds can be used as industrial solvents, especially as ligands for efficient catalyst recycling.
Owner:ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
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