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Venlafaxine hydrochloride sustained-release capsule and preparation method thereof

A technology of venlafaxine hydrochloride and sustained-release capsules, which is applied in the field of medicine, can solve the problems of high solution viscosity and low drug yield, and achieve the effects of simple preparation process, consistent sustained-release curve, and cost-saving production

Inactive Publication Date: 2015-09-02
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem of low yield of the drug-on-ball method, the present invention has found through research that after venlafaxine hydrochloride is dissolved in ethanol, the solution viscosity is high, which is very suitable for drug-on-fluidized bed solution, but the solution viscosity is closely related to the ethanol concentration , it is necessary to strictly control the concentration of ethanol

Method used

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  • Venlafaxine hydrochloride sustained-release capsule and preparation method thereof
  • Venlafaxine hydrochloride sustained-release capsule and preparation method thereof
  • Venlafaxine hydrochloride sustained-release capsule and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036]

[0037] Preparation method: Weigh the prescribed amount of venlafaxine hydrochloride and add it to a certain amount of ethanol, stir and dissolve to make a drug solution; then weigh the prescribed amount of hypromellose and add it to a certain amount of water, stir to dissolve, and then Add the prescription amount of talcum powder to make spacer; add polyvinyl acetate-povidone to water to make dispersion liquid, then add triethyl citrate and talc powder, and stir to make it evenly dispersed. Use the sucrose core as the substrate to coat the drug solution, spacer, and coating solution on the surface of the core by using a fluidized bed until the coating solution is completely sprayed to obtain drug-containing sustained-release pellets, and the drug-containing pellets Fill into hard capsules.

Embodiment 2

[0039]

[0040] The preparation method is the same as in Example 1.

Embodiment 3

[0042]

[0043] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a venlafaxine hydrochloride sustained-release capsule and a preparation method thereof, wherein the sustained-release capsule is composed of a sustained-release pillet and a capsule shell; the substrate of the sustained-release pillet is an inert pillet core; and a fluidized bed respectively comprises a medicine layer, an isolation layer and a sustained-release layer. Compared with the traditional rolling extrusion method, the preparation method disclosed by the invention is simple; and simultaneously, because of optimal selection of a coating layer, long-term release of medicines can be realized.

Description

technical field [0001] The invention relates to a capsule and a preparation method thereof, in particular to a venlafaxine hydrochloride sustained-release capsule and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Venlafaxine hydrochloride is an effective antidepressant with the chemical name (R / S)-1-[2-(dimethylamine)-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride, which belongs to the biogenic amine reuptake inhibitors of serotonin, norepinephrine and dopamine, mostly exists in the form of hydrochloride in the drug, and is clinically used for various types of depression, including those with Anxious depression and generalized anxiety disorder. [0003] Venlafaxine Hydrochloride Sustained-release Capsules are produced by Wyeth, and the trade name is Effexor, specifications: 75mg and 150mg. They are hard capsules, and the contents are white to off-white spherical pellets. In the claims of patent 97109594.9, it...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/137A61K47/38A61K47/32A61P25/24
Inventor 房金波郭璇章晓骅徐丹朱春霞田舟山
Owner NANJING CHIA TAI TIANQING PHARMA
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