84results about How to "High graft density" patented technology

The invention relates to a temperature-responsive three-dimensional ordered macroporous controlled-release material. The apertures of a macropore and a communicating window of the controlled-release material are uniform, wherein the aperture of the macropore is 100-1000nm, the communicating window has a size of 40-120nm and the pore volume is 1.3-2.8cm<3> / g; and a substrate of the controlled-release material is monodisperse three-dimensional ordered macroporous crosslinked polystyrene with mutually communicated windows, a polymer chain segment with temperature responsiveness is introduced onto the substrate through an atom transfer radical activity-controlled graft polymerization method, and the on-off control of the communicating window between macropores is realized by utilizing the extending-curling action of the temperature-responsive polymer chain segment under different temperatures: a macroporous chain gradually shrinks along with the temperature rise, the pore window gradually opens, and furthermore, the controlled-release action on filled and packaged substances is achieved. The temperature-responsive three-dimensional ordered macroporous controlled-release material has extensive application values in the fields of controlled-release of biomedicines, drug controlled-release systems, controlled release-embedding of active enzyme and catalysts, and the like.

The invention relates to an anticoagulant polyurethane material formed by a decorate layer and a base layer, wherein, the base layer is formed by general commercial polyurethane material or composite polyurethane material, and the decorate layer is formed by chemically decorating the face of base layer. The decorate layer contains the PEG flexible distant group connected with the polyurethane base via covalence key and the active lycine lead by the NHS via surface grafting and the function group covalence key at the end of PEG. The inventive preparation comprises that using MDI to function the PU material, surface grafting the PEG, leading in NHS active reaction group, grafting lycine, and de-protecting theepsilon-NH2 of lycine. The invention has better anticoagulant and plug-dissolving functions, to eliminate the blood plug.

The invention provides magnetic shell-core structural nanoparticles and a preparation method and application thereof. The magnetic shell-core structural nanoparticles comprise a plurality of magnetic nanoparticles, silica shell layers coating the plurality of magnetic nanoparticles, porous silica shell layers coating the silica shell layers and dipeptide-functionalized polymer grafted to surfaces of the porous silica shell layers. The method comprises: preparing magnetic nanoparticles, coating the silica shell layers and the porous silica shell layers with the magnetic nanoparticles, performing modification with a siloxane crosslinking modifier, and finally grafting the surfaces of the porous silica shell layers, which is modified with siloxane, with the dipeptide-functionalized polymer to obtain the magnetic shell-core structural nanoparticles. The magnetic shell-core structural nanoparticles can be applied to enrichment and separation of glycosylated protein. The magnetic shell-core structural nanoparticles successfully combine with dispersive solid-phase extraction, thereby achieving high-selectivity, good-repeatability and high-throughput enrichment of glycosylated protein and polypeptide materials.

The invention relates to a nanofiber substrate as well as a preparation method of the nanofiber substrate and applications of the nanofiber substrate in CTC efficient capture and non-destructive release. The nanofiber substrate provided by the invention comprises a lining substrate, a nano-structure layer, an adhesion-resisting molecular layer and an affinity capture molecular layer which are connected in sequence. The preparation method of the nanofiber substrate comprises the following steps: preparing for the lining substrate; depositing the nano-structure layer on the lining substrate; grafting the adhesion-resisting molecular layer to the nano-structure layer; and connecting the affinity capture molecular layer on the adhesion-resisting molecular layer. The nanofiber substrate provided by the invention has good cell compatibility, the captured CTC sample has relative high activity and purity, and free CTC samples can be obtained through the hybridization effect of complementary chains and aptamers.

The present invention discloses an anti-impact heat-dissipating coating material, which which comprises the following raw materials by weight: 4-7 parts of soapstone, 2-3 parts of polyether diol, 12-15 parts of a styrene-maleic anhydride copolymer, 6-10 parts of propargyl alcohol, 90-100 parts of tetrahydrofuran, 4-7 parts of graphene, 16-20 parts of nanometer silica, 0.2-0.3 part of a silane coupling agent KH560, 700-800 parts of dimethylformamide, 4-5 parts of sodium nitride, 0.04-0.05 part of aluminum trichloride, 1.6-2 parts of a 2-3% sodium ascorbate solution, 1.8-2 parts of a 2-3% copper sulfate solution, 120-130 parts of high-density polyethylene, 0.1-0.3 part of sodium fluoroborate, 3-4 parts of dibutyl phthalate, 0.7-2 parts of 8-hydroxyquinoline, and 1-2 parts of calcium propionate. According to the present invention, the coating material is added with the soapstone, the graphene, the nanometer silica and the like as the filler particles, such that the good anti-impact strength is provided.

The invention discloses L-carnitine molecularly imprinted microspheres with a core-shell structure and a preparation method thereof, and relates to the field of intelligent high polymer materials. According to the invention, L-carnitine is taken as a template molecule and methacrylic acid is taken as a functional monomer, and the L-carnitine molecularly imprinted microspheres with the core-shell structure are prepared through reversible addition-fragmentation chain transfer and free radical polymerization in combination with the surface molecular imprinting technology; the preparation method of the L-carnitine molecularly imprinted microspheres with the core-shell structure comprises the following steps of: 1, preparing nano SiO2 microspheres by a Stober method; 2, performing surface activation on the nano SiO2 microspheres; 3, performing surface benzylation on the nano SiO2 microspheres; 4, synthesizing an RAFT (Reversible Addition-Fragmentation Chain Transfer Polymerization) reagent on the surface of the nano SiO2 microspheres; 5, preparing the L-carnitine molecularly imprinted microspheres with the core-shell structure; and 6, eluting the imprinted template molecules. The L-carnitine molecularly imprinted microspheres with the core-shell structure has the advantages of simple process, low cost, convenience in industrial popularization and application, and the like; the obtained imprinted microspheres have good adsorbability and selectivity for L-carnitine molecules, and can be applied to separating out carnitine enantiomers.

The invention discloses a polymer brush type magnetic graphene oxide adsorbing material and a preparation method thereof, and relates to the field of adsorbing materials. The adsorbing material provided by the invention comprises graphene oxide, magnetic Fe3O4, polydopamine and a polymer brush. The magnetic Fe3O4 is dispersed on the surface of the graphene oxide in a nano-particle shape to form magnetic graphene oxide; the surface of the magnetic graphene oxide is coated with the polydopamine; the polymer brush is grafted on the polydopamine; the polymer brush includes poly(4-sodium vinylbenzene sulfonate-co-methacryloyloxyethyl trimethyl ammonium chloride). The polymer brush grafted on the surface of the adsorbing material has characteristic functional groups, so that the adsorption selectivity is improved. According to the preparation method of the adsorbing material, graphene with a large specific surface area is used as a matrix, the polymer brush is grafted by combining an SI-ATRPtechnology with a high grafting characteristic, a grafting layer is uniform, the grafting density is high, and the density of functional groups is effectively improved, so that the adsorption capacity of the adsorbing material is improved.

The invention relates to an amino silane modified nanocellulose aerogel preparation method. The method includes: 1) making nanocellulose suspension liquid into semi-transparent colloid; 2) extruding the nanocellulose colloid to form spherical or short rod-like hydrogel; 3) turning the formed nanocellulose hydrogel into alcogel; 4) making nanocellulose aerogel; 5) allowing adsorption of gaseous organic amine on the surface of the nanocellulose aerogel; 6) performing vacuum recovery of residual organic amino catalysts; 7) allowing chemical reaction of gaseous amino silane and the nanocellulose aerogel; 8) performing vacuum recovery of unreacted amino silane and 9) making corresponding amino silane modified nanocellulose aerogel. The method has advantages that 1) solvent recovery and separation in a liquid-phase modification process can be avoided, and an amination modification process is simplified; 2) an original microcosmic three-dimensional network structure of nanocellulose aerogel is kept, and modification grafting density and uniformity are improved; 3) process simplicity, high efficiency and low cost are realized.

The invention provides a method for grafting DNA on polydopamine nanoparticle surface with controllable density. According to the method, the grafting density of DNA on polydopamine nanoparticle surface is controlled in the manner of adding metal cations into a reaction system. According to the method provided by the invention, the DNA grafted polydopamine nanoparticle with controllable grafting density can be acquired, wherein the maximal grafting density of DNA on the surface of polydopamine nanoparticle in grain size of 250nm can reach up to 34.60pmol / cm2 and is far more than the maximal grafting density (21pmol / cm2) of DNA on the surface of gold nanoparticle in grain size of 250nm.

The present invention discloses hard heat-dissipation paint. The hardheat-dissipation paint consists of the following raw materials in parts by weight:2-3 parts of ethylene glycol distearate, 12-15 parts of styrene-maleic anhydride copolymer, 6-10 parts of propargyl alcohol, 90-100 parts of tetrahydrofuran, 4-7 parts of graphene, 16-20 parts of nano silica, 0.2-0.3 part of a silane coupling agent KH560, 700-800 parts of dimethyl formamide, 4-5 parts of sodium nitride, 0.04-0.05 part of aluminium trichloride, 1.6-2 parts of a 2-3% sodium ascorbate solution, 1.8-2 parts of a 2-3% copper sulfate solution, 120-130 parts of high density polyethylene, 2-3 parts of barium metaborate, 0.8-1 part of calcium palmitate, 0.7-2 parts of allythiourea, 0.6-1 part of poly(oxypropylene) diol, 1-2 parts of aluminosilicate fibers, and 0.1-0.2 part of aluminum isopropoxide. The paint provided by the present invention is high in the surface hardness, good in the impact resistance, good in weather-ability, high in coating membrane stability, and superior in synthesis performance.

A hydrophilic anti-pollution polyamide composite reverse-osmosismembrane, comprising a porous supporting layer, a crosslinking polyamide layer and an acrylate or methacrylate structural unit which is grafted to the crosslinking polyamide layer by a free radical polymerization reaction and contains hydrophilic groups, the hydrophilic groups being an amino and / or a hydroxy; the preparation method therefor comprises that a membrane containing the crosslinking polyamide layer is prepared on the porous supporting membrane by a surface polymerization method, a solution containing an initiator and a solution containing a water-soluble acrylate or methacrylate monomer are successively put into contact with the surface of the crosslinking polyamide layer of the membrane, and then the hydrophilic anti-pollution polyamide composite reverse-osmosismembrane is obtained by means of a heat treatment.

The invention discloses extreme-pressure lubricating and cutting liquid which consists of the following raw materials in parts by weight: 1 to 2 parts of N-hydroxymethyl acrylamide, 3 to 4 parts of isopropyl palmitate, 1 to 2 parts of para toluene sulfonamide, 4 to 6 parts of T405 sulfurized olefin cottonseed oil, 0.2 to 0.3 part of copper sulfate, 10 to 17 parts of styrene, 3 to 4 parts of maleic anhydride, 0.1 to 0.2 part of benzoyl peroxide, 5 to 7 parts of nano-silicon dioxide, 1 to 2 parts of propargyl alcohol, 0.4 to 1 part of sodium nitride, 0.6 to 1 part of aluminum chloride, 0.7 to 1 part of a silane coupling agent kh560, 0.1 to 0.2 part of sodium ascorbate, 2 to 3 parts of polyoxypropylene glycerol ether, 2 to 3 parts of polyglycerol fatty acid ester, 0.1 to 0.2 part of molybdenum oxide and 2 to 3 parts of calcium phosphate. Unsaturated residual bond and hydroxyl with different bonding states which exist on the surface of the nano-silicon dioxide enable the surface of the nano-silicon dioxide to achieve high surface activity, and the nano-silicon dioxide is easily deposited on the friction surface of metal, so that the lubricating property of the cutting liquid is improved.

The invention relates to an alginate-chitosan microcapsule modified via in situ covalent PEG grafting. The structure of the microcapsule is divided into two parts, i.e., a microcapsule membrane and an inner core, wherein the microcapsule membrane is a polyelectrolyte composite hydrogel membrane formed by chitosan and alginate, the surface of the membrane is modified via in situ covalent PEG grafting, and the inner core is an alginate liquid or alginate hydrogel environment containing living cells. Because of resistance to protein adsorption, the microcapsule is applied to living cell encapsulation and used as an immunoisolation carrier for cell transplantation.