Thrombus filter capable of realizing delayed recovery and preparation method of thrombus filter

Abstract

The invention discloses a thrombus filter capable of realizing delayed recovery and a preparation method of the thrombus filter and particularly discloses a blood compatible coating. The blood compatible coating comprises a polyacrylic acid layer and a polyethylene glycol layer, and 2-methacryloyloxyethyl phosphorylcholine is covalently linked with the surface of the polyethylene glycol layer. Theinvention further discloses medical apparatus such as the thrombus filter coated with the blood compatible coating. According to the technical scheme, thrombogenesis and endothelial tissue growth canbe better inhibited. The whole surface coating is adjustable in thickness and surface grafting amount and can well bear stress and strain actions in apparatus assembly and release processes, molecules are firmly combined without falling off, and mechanical properties of the apparatus are not affected.

Description

technical field [0001] The invention belongs to the field of medical devices and relates to a thrombus filter, in particular to a delayed recovery thrombus filter and a manufacturing method thereof. Background technique [0002] Pulmonary embolism (PE) is a clinical and pathophysiological syndrome in which endogenous or exogenous emboli block the pulmonary artery or its branches and cause pulmonary circulation disturbance. PE is usually caused by deep vein thrombosis. Severe PE can cause dyspnea, Syncope, abnormal hypotension and even sudden death. PE is usually treated with anticoagulant and thrombolytic therapy. If anticoagulant therapy fails or the effect is poor, implantation of inferior vena cava filters (IVCFs) may be required. [0003] In general, IVCFs are made of stainless steel, titanium and its alloys, NiTi alloys, and other materials, but these materials have poor blood compatibility and are prone to thrombosis after implantation, thereby causing greater risks; ...

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Problems solved by technology

[0003] In general, IVCFs are made of stainless steel, titanium and its alloys, NiTi alloys, and other materials, but these materials have poor blood compatibility and are prone to cause thrombosis after implantation, thereby causing greater risks; at the same time, when After the filter is implanted in the inferior vena cava, due to the growth of vascular endothelial cells and smooth muscle cells on the surface of the filter and the adsorption and activation of fibrinogen in the blood on the surface of the material, it is easy to cause severe endothelialization or tissue proliferation on the surface of the filter, so that the filter can be removed Very difficult; moreover, the recovery hook on the filter is often covered with fibrin, making the operation of removing the filter extremely difficult

In addition, when the IVCF stays in the body for a long time, it is easy to cause clinical side effects such as filter displacement and secondary thrombus formation. Therefore, a large number of patients with implanted thrombus filters need to take out the thrombus filters. Take it out, otherwise it will be difficult to take it out again, but the patient has not been cured within a week or so, and pulmonary embolism still needs to be prevented. treatment is very important

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