37 results about "Blood compatible" patented technology

A labeling system to ensure that blood products are compatible with a patient's blood type. A blood product housing, which is attached to a blood product, comprises a plurality of block-like projections and recesses corresponding to the antigens / antibody characteristics of a blood product. A patient housing, secured to the patient, comprises a plurality of mirror image three-dimensional block-like projections and recesses corresponding to the antigen / antibody characteristics of the patient's blood. If the blocks and recesses of the housings mate and seat to one another this confirms the blood product is compatible with the blood of the patient. If the blocks and recesses of the housings do not mate and seat to one another this confirms the blood product is not compatible with the blood of the patient.

Disclosed herein is a medical device, comprising a covalently-bonded heparin coating on a substrate, where the covalently bonded heparin coating is the reaction product of (a) an isocyanate-bearing material on or covalently bonded to the substrate and (b) a heparin molecule selected from one of the formulae in the claims. The current invention also relates to a method of forming the medical device, which may be useful as heart stent or intravascular stent that is hemocompatible for preventing the formation of blood clots.

The invention relates to a blood-compatible polymer layer and a preparation method thereof. Under the condition of ultraviolet light irradiation, a copolymerization reaction of 6-acrylamidocaproic acid and N-vinylpyrrolidone is initiated on the surface of a silanized substrate to obtain the preparation method. The blood-compatible polymer layer; the water contact angle of the prepared blood-compatible polymer layer is 40 to 45°; after the blood-compatible polymer layer is grafted on the surface of the silanized substrate, the BSA and Fib proteins are adsorbed The amount was reduced by 75-80% and 60-68% respectively. Using laser confocal microscope test, no obvious adhesion phenomenon was observed on the red blood cell adhesion test picture and the platelet adhesion test picture. The invention utilizes ultraviolet light to initiate the copolymerization of AACA and NVP monomers, and introduces a blood-compatible polymer layer with hydrophilic-hydrophobic balance ability on the surface of the substrate, the operation is simple, the reaction process is controllable, clean and pollution-free, and large-scale production is possible; The blood-compatible polymer layer has excellent anti-protein adsorption properties, anti-erythrocyte adhesion properties and anti-platelet adhesion properties.

The present invention relates to the medical industry. In particular, it is related to a polyvinyl chloride polymer (PVC) functionalized for medical use, which is flexible and compatible with blood. Specifically, this invention is related to a biomolecule-functionalized PVC and its production method, in order to produce a flexible and blood-compatible polymer for medical use.

The invention provides a chitosan-polylactic acid graft copolymer and a preparation method and an application thereof; the preparation method is to adopt supercritical carbon dioxide fluid as reaction medium and lipase as catalyst to perform graft copolymerization between chitosan or derivative thereof and lactide monomer. The invention is simple to operate, the products are easy to separate, no organic solvent is used in the preparation and purification of the copolymer, the method has no pollution to the environment, and the obtained copolymer has excellent biocompatibility and good mechanical properties so that the copolymer can be used as body-implanted biological materials such as the scaffold for tissue engineering, the carrier for self-assemble micelle drugs, blood compatible material and the like.

The invention discloses cyclic biodegradation aliphatic polyester and a preparation method thereof. The cyclic biodegradation aliphatic polyester is prepared through combination of ring opening polymerization and click chemical reaction. The preparation method comprises the following steps of adopting small-molecule alcohol containing acetylene alkynyl as an initiator to initiate ring opening polymerization of a cyclic ester monomer so as to prepare single-end alkynylation biodegradation aliphatic polyester; enabling the single-end alkynylation biodegradation aliphatic polyester and acid halide and sodium azide to perform reaction sequentially to prepare linear biodegradation aliphatic polyester containing the acetylene alkynyl and azide group; and finally, preparing the cyclic biodegradation aliphatic polyester through the click chemical reaction. The ring size of the cyclic biodegradation aliphatic polyester is controllable, reaction conditions are moderate, and reaction products are pure. In addition, the cyclic biodegradation aliphatic polyester has a topological structure and performance which are different from a structure and the performance of corresponding linear biodegradation aliphatic polyester and can be well applied in the aspects of sustained or controlled release of drug carriers, scaffolds for tissue engineering, blood compatible materials and the like.