52results about How to "Excellent drug release performance" patented technology

The present invention relates to a sustained-release solid pharmaceutical formulation comprising (a) an active medical ingredient, (b) a pre-gelatinized starch in an amount of 10 to 90 % by weight based on the whole weight of the formulation and (c) one or more kinds of enteric ingredients.

The present invention provides a patch preparation that has an extremely low moisture permeability, has a sufficient ODT effect, is excellent in drug releasability and in anchoring property of its drug-containing pressure-sensitive adhesive layer, and has a preferred patch feeling. The patch preparation of the present invention includes a support; and a pressure-sensitive adhesive layer containing an adherent polymer and a drug on one surface of the support, wherein: the support has a polyester base layer, an inorganic oxide layer, and a polyester nonwoven fabric layer in the stated order; the polyester base layer has a thickness of 1.0 μm to 16 μm; and the pressure-sensitive adhesive layer is laminated on the polyester nonwoven fabric layer.

The present invention relates to a sustained-release solid pharmaceutical formulation comprising (a) an active medical ingredient, (b) a pre-gelatinized starch in an amount of 10 to 90% by weight based on the whole weight of the formulation and (c) one or more kinds of enteric ingredients.

Water-soluble chitosan microspheres that can be used to load drugs and a preparation method thereof. The structure of the microsphere is that the cross-linked water-soluble chitosan core that can be loaded with drugs is sequentially wrapped with a cross-linked water-soluble chitosan coating layer and a cross-linked cured outer layer, which can be used for drug loading and control. freed. The preparation method is to first form a W / O mixture of water-soluble chitosan and corresponding water-dispersed drugs and oily ingredients, react with dialdehyde cross-linking agents to obtain drug-loaded microsphere cores, and then water-soluble shells The polysaccharide solution forms a cross-linked covering layer on its outside, and finally forms a cross-linked solidified surface layer through a second cross-linking reaction. The particle size distribution and sustained release effect of the chitosan drug-loaded microspheres are controllable, the strength is significantly improved, the biocompatibility and bioadhesion are good, the application range of drug loading is expanded, and the drug entrapment and controlled release effects are good. It can be used in multiple administration methods such as subcutaneous, intravenous and intraperitoneal injection, oral administration, etc., and the preparation method is simple and easy, the conditions are mild, and the production cost is low.

The invention discloses a nano-lipid carrier for embedding vitamin A alcohol and a preparation method of the nano-lipid carrier for embedding the vitamin A alcohol, relates to the field of skin-care products, and solves the problems of high irritation and poor stability caused by directly applying the vitamin A alcohol to the skin-care products. The nano-lipid carrier for embedding the vitamin A alcohol comprises the following components in weight by percentage: 8 to 12% of Hawaiian soybean oil, 8 to 12% of palm wax, 1 to 5% of vitamin A alcohol, 8 to 12% of a nonionic surfactant, 1 to 3% of an alcohol solvent, 0.1 to 1% of phospholipid and the balance of water. According to the invention, the raw materials of the Hawaiian soybean oil, the palm wax, the surfactant and the like are mutuallymatched for embedding the vitamin A alcohol, the nano-lipid carrier for embedding the vitamin A alcohol is applied to the skin-care products, so that the skin-care products have the advantages of lowirritation, good drug release and the like and oxidation of the vitamin A alcohol is avoided; an embedding system in the invention can well embed the vitamin A alcohol, and the embedding rate is close to 100%; the interface potential value of the nano-lipid carrier is between minus 33mV to minus 49mV, and the nano-lipid carrier further has good stability and dispersion.

Provided is an adhesive sheet for adhesion to the skin, which has sufficient adhesiveness and causes low skin irritation. The adhesive sheet comprises a support and an adhesive layer formed on the support, in which the adhesive layer contains at least a thermoplastic elastomer and a non-volatile hydrocarbon oil. Further provided is a transdermal absorption preparation having sufficient adhesiveness and drug releaseability and causes low skin irritation. The transdermal absorption preparation comprises an adhesive sheet as described herein and a drug or a pharmaceutically acceptable salt thereof that is contained in the adhesive layer of the sheet.