Soluble self-healing natural polymer hydrogel and preparation method thereof

A natural polymer and hydrogel technology, applied in bandages, surgery, surgical adhesives, etc., can solve problems such as insoluble, slow healing speed, and limited incision healing, and achieve long release time, stable release rate, and healing efficiency high effect

Active Publication Date: 2019-05-07
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a soluble self-healing natural polymer hydrogel and its preparation in order to solve the problems of slow healing speed, limited incision healing and insolubility in the existing self-healing hydrogel The method has abundant sources of raw materials, is environmentally friendly, has a simple preparation method, is economical and has good biocompatibility

Method used

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  • Soluble self-healing natural polymer hydrogel and preparation method thereof
  • Soluble self-healing natural polymer hydrogel and preparation method thereof
  • Soluble self-healing natural polymer hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Synthesis of Soluble Self-Healing Hydrogel (SAM-1)

[0040] Weigh a certain amount of sodium alginate and add it to deionized water (the mass ratio of sodium alginate to deionized water is 4:100), stir at 1500rpm for 3 hours until the sodium alginate is completely dissolved, put the sodium alginate solution in Put it in a refrigerator at 3°C, stabilize it for 3 hours, and wait until it becomes a colorless and transparent sodium alginate aqueous solution.

[0041] Add the prepared sodium alginate aqueous solution into the three-necked flask, stir at 1500rpm for 10 minutes, then slowly add deionized water (the mass ratio of sodium alginate solution to deionized water is 4:1), maintain the stirring speed, and continue stirring For 30 minutes, the temperature was kept at 25°C.

[0042] To the mixed sodium alginate solution, slowly add methacrylic acid (the mass ratio of sodium alginate mixed solution to methacrylic acid is 8:1), and the dropwise addition is completed withi...

Embodiment 2

[0045] Synthesis of Soluble Self-Healing Hydrogels (SAM-2)

[0046] Weigh a certain amount of sodium alginate and add it to deionized water (the mass ratio of sodium alginate to deionized water is 2:100), stir at 1200rpm for 5 hours until the sodium alginate is completely dissolved, put the sodium alginate solution in Put it in a refrigerator at 8°C, stabilize it for 6 hours, and wait until it becomes a colorless and transparent sodium alginate aqueous solution.

[0047] Add the prepared sodium alginate aqueous solution into a three-necked flask, stir at 1200rpm for 10 minutes, then slowly add deionized water (the mass ratio of sodium alginate solution to deionized water is 4:2), maintain the stirring speed, and continue stirring 50min, the temperature was kept at 25°C.

[0048] To the mixed sodium alginate solution, slowly add methacrylic acid (the mass ratio of sodium alginate mixed solution to methacrylic acid is 4:1), the dropwise addition is completed within 2 hours, kee...

Embodiment 3

[0051] Synthesis of Soluble Self-Healing Hydrogel (SAM-3)

[0052] Weigh a certain amount of sodium alginate and add it to deionized water (the mass ratio of sodium alginate to deionized water is 1:100), stir at 800rpm for 6 hours until the sodium alginate is completely dissolved, put the sodium alginate solution in Put it in a refrigerator at 10°C, stabilize it for 10 hours, and wait until it becomes a colorless and transparent sodium alginate aqueous solution.

[0053] Add the prepared sodium alginate aqueous solution into the three-necked flask, stir at 800rpm for 10 minutes, then slowly add deionized water (the mass ratio of sodium alginate solution to deionized water is 4:3), maintain the stirring speed, and continue stirring For 60 minutes, the temperature was kept at 25°C.

[0054] To the mixed sodium alginate solution, slowly add methacrylic acid (the mass ratio of sodium alginate mixed solution to methacrylic acid is 2:1), and the dropwise addition is completed withi...

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Abstract

The invention discloses a soluble self-healing natural polymer hydrogel and a preparation method thereof. Natural polymer sodium alginate can be used as raw material, functional monomer methacrylic acid can be introduced, initiator and deionized water can be used as auxiliary raw material, and thus the natural polymer hydrogel (SAM) with excellent self-healing and solubility can be prepared by one-pot method. The hydrogel prepared by the invention has the advantages of fast self-healing rate, healing with no limitation of incision section and good solubility. The hydrogel is put into a certainamount of water, and the hydrogel can be completely dissolved without residue. The hydrogel is used as a drug carrier, and the drug release rate is stable, and the 100% of drug can be completely released without residue. And the prepared hydrogel has good biocompatibility and degradability, and the soluble self-healing natural polymer hydrogel prepared by the invention has wide application prospects in the fields of biomedical materials such as wound dressing, tissue organ culture and biological scaffold materials.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, in particular to a natural polymer hydrogel (SAM) with dissolving and self-healing properties and a preparation method thereof. Background technique [0002] Self-healing hydrogel means that when the hydrogel itself is damaged by external force, the hydrogel can achieve self-healing through a dynamic cross-linked network. Self-healing hydrogels can not only guarantee the excellent swelling properties, mechanical toughness, biocompatibility, and easy modification of the hydrogel itself, but more importantly, the excellent self-healing properties make hydrogels gain a lot of attention in the field of biomaterials. Widespread concern. Wound healing is a complex biological process that includes coagulation, inflammation, exudation, synthesis, and regeneration. Due to the exudation of wound tissue fluid, traditional wound dressings often adhere to the wound, causing secondary trauma when c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/04C08L33/02C08F120/06A61L24/08A61L24/00A61L26/00
Inventor 徐敏黄海龙王艳玲付晓彬
Owner EAST CHINA NORMAL UNIV
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