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Low-polylactic acid-beta-cyclodextrin and polylactic acid blended nano-fiber prepared by electrospinning

A technology of nanofibers and cyclodextrins, which can be used in fiber processing, filament/thread forming, textiles and papermaking, etc. It can solve the problems of functional loss and achieve good compatibility, good biocompatibility, firm adhesion attached effect

Inactive Publication Date: 2012-12-19
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the shortcoming of loss of functionalization in the process of electrospinning blending modification, the present invention utilizes the characteristic of oligomeric lactic acid-β-cyclodextrin to migrate to the surface during the spinning process, and prepares a functionalized surface-enriched cyclodextrin Nanofibers

Method used

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  • Low-polylactic acid-beta-cyclodextrin and polylactic acid blended nano-fiber prepared by electrospinning
  • Low-polylactic acid-beta-cyclodextrin and polylactic acid blended nano-fiber prepared by electrospinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Dissolve oligomeric lactic acid-β-cyclodextrin with a weight average molecular weight of 3000 and polylactic acid with a weight average molecular weight of 100,000 in dichloromethane with a volume ratio of 1:1 in a mass ratio of 1:10 In a mixed solvent of N,N-dimethylformamide (DMF), prepare a solution with a weight percentage of 20wt%, then stir the solution fully until it is completely dissolved, and place the solution in ultrasonic for 1 hour to make all the bubbles precipitate out That is, a transparent oligomeric lactic acid-β-cyclodextrin / polylactic acid blend solution is obtained.

[0019] (2) Add the oligomeric lactic acid-β-cyclodextrin / polylactic acid blend electrospinning solution prepared in step (1) into the syringe pump, and adjust the spinning voltage to 15kV; the distance from the spinneret to the collecting plate is 15cm; the flow rate of the spinneret spinning solution is 1.5mL / h; the collector is aluminum foil, and the device is started to perform...

Embodiment 2

[0021] (1) Dissolve oligomeric lactic acid-β-cyclodextrin with a weight average molecular weight of 5000 and polylactic acid with a weight average molecular weight of 200,000 in a mass ratio of 5:10 in dichloromethane with a volume ratio of 1:1 In a mixed solvent of N,N-dimethylformamide (DMF), prepare a solution with a weight percentage of 15wt%, then stir the solution fully until it is completely dissolved, and place the solution in ultrasonic for 1 hour to make all the bubbles precipitate out That is, a transparent oligomeric lactic acid-β-cyclodextrin / polylactic acid blend solution is obtained.

[0022] (2) Add the oligomeric lactic acid-β-cyclodextrin / polylactic acid blend electrospinning solution prepared in step (1) into the syringe pump, and adjust the spinning voltage to 15kV; the distance from the spinneret to the collecting plate is 15cm; the flow rate of the spinneret spinning solution is 1.5mL / h; the collector is aluminum foil, and the device is started to perform...

Embodiment 3

[0024] (1) Dissolve oligomeric lactic acid-β-cyclodextrin with a weight average molecular weight of 8000 and polylactic acid with a weight average molecular weight of 300,000 in a mass ratio of 8:10 in dichloromethane with a volume ratio of 1:1 and N,N-dimethylformamide (DMF) in a mixed solvent to prepare a solution with a weight percentage of 10wt%, then stir the solution fully until it is completely dissolved, and place the solution in ultrasonic for 1 hour to make all the bubbles precipitate out That is, a transparent oligomeric lactic acid-β-cyclodextrin / polylactic acid blend solution is obtained.

[0025] (2) Add the oligomeric lactic acid-β-cyclodextrin / polylactic acid blend electrospinning solution prepared in step (1) into the syringe pump, and adjust the spinning voltage to 15kV; the distance from the spinneret to the collecting plate is 15cm; the flow rate of the spinneret spinning solution is 1.5mL / h; the collector is aluminum foil, and the device is started to perf...

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Abstract

The invention relates to a method for manufacturing a low-polylactic acid-beta-cyclodextrin and polylactic acid blended nano-fiber. The method includes dissolving low-polylactic acid-beta-cyclodextrin and polylactic acid in methylene chloride and N,N-dimethylformamide (DMF), stirring the mixture until the low-polylactic acid-beta-cyclodextrin and the polylactic acid are completely dissolved, and performing standing ultrasonic treatment for the solution to obtain transparent low-polylactic acid-beta-cyclodextrin and polylactic acid solution; and adding the low-polylactic acid-beta-cyclodextrin and polylactic acid blended solution in an injection pump, adjusting electrospinning voltage to range from 15kV to 28kV, setting the distance from a spinning nozzle to a collecting plate to range from 15cm to 25cm and solution flow rate to range from 1.0mL / h to 2.0mL / h, using a collector as an aluminum foil and carrying out high-voltage electrospinning to obtain the low-polylactic acid-beta-cyclodextrin and polylactic acid blended nano-fiber. The prepared functional nano-fiber has excellent biocompatibility and biodegradability and accordingly has a high application value in drug controlled release systems.

Description

technical field [0001] The invention is based on the electrospinning method to prepare the functionalized nanofiber with drug controlled release performance. The invention belongs to the field of preparation of functionalized polymer nanofibers. technical background [0002] Electrospinning technology is a cheap and efficient way to prepare nanofibers. The polymer solution with a certain chain entanglement is stretched and refined under the action of high-voltage electrostatic, and is accompanied by the volatilization and solidification of the solvent to form nanometer to submicron electrospun fibers. During the electrospinning process, the fiber diameter and diameter distribution can be controlled by adjusting the spinning voltage, spinning distance and polymer solution concentration, which is an ideal method for preparing nanofibers. In recent years, a large number of literatures have reported the preparation of different kinds of polymers, natural polymers and inorganic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/92D01F8/14D01D5/00
Inventor 马贵平陈洁聂俊方大为李刚
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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