192results about How to "Good controlled release effect" patented technology

The invention relates to an enveloped controlled release fertilizer and method for preparation which consists of, preheating the urea particles to a predetermined temperature, spraying the molten liquid state sulfur to the urea particles, forming a layer of smooth and compact sulfur-coated urea, charging hot-curing resin component on the sulfur-coated urea for even distribution onto the urea particle surface and fast formation.

The invention relates to an enveloped controlled release fertilizer and method for preparation which consists of, preheating the urea particles to a predetermined temperature, spraying the molten liquid state sulfur to the urea particles, forming a layer of smooth and compact sulfur-coated urea, charging hot-curing resin component on the sulfur-coated urea for even distribution onto the urea particle surface and fast formation.

The invention discloses a preparation method of sericin hydrogel, the method is as follows: first, weighting domestic silkworm fibroin deletion form mutation variety silkworm cocoon for LiBr or LiCl extraction and dialysis and purification to obtain a non-degradable sericin water solution with a mass percentage concentration of 0.1-4%; concentrating the sericin water solution to 1.5-10%, adding a cross-linking agent to the concentrated sericin water solution (wherein 2-500muL of the cross-linking agent is added into each L of the sericin water solution), fully mixing, and placing at 4-45 DEG C for 5 seconds to 36 hours to obtain the sericin hydrogel. The sericin hydrogel has biological activity and multiple functions, can be used as carrying growth factors, drugs and cell carriers treatment, and can be applied in repair of a variety of soft tissue injuries, including but not limited to skin damages, muscle damages, injuries of blood vessel, nerve injuries, myocardial damages, and the like, and treatment of diseases.

The invention discloses a production method of a biological carbon coated controlled-release fertilizer and belongs to the technical field of recycling of agricultural waste and soil fertilizer. The production method comprises the following steps: crushing dry biomass material, performing pyrolysis for 0.5-12 hours under an anaerobic condition at 250-800 DEG C to form biological carbon granules, and cooling and grinding to obtain biological carbon powder with the particle size of 74-180 microns; screening granular fertilizer, transferring the screened granular fertilizer into a blast fluidized bed, preheating, and then spraying a binding agent to ensure that the surface of the continuously rolling granular fertilizer is coated with the binding agent and a uniform liquid layer is formed gradually; and spraying the biological carbon powder to the continuously rolling granular fertilizer, continuously heating to keep the material temperature at 60-70 DEG C, treating for 10-15 minutes so that the moving granular fertilizer is coated with the biological carbon powder and a coating layer is formed after curing, coating the fertilizer for 2-5 times, uniformly mixing, and then performing air drying or pelleting by virtue of a pelleting machine or performing compression mold forming. The controlled-release fertilizer obtained by the method disclosed by the invention is degradable and has a good controlled release effect.

The invention belongs to the technical field of emulsion preparation, and discloses a stable-protein high-internal-phase oil-in-water emulsion and a preparation method thereof. The method comprises the following steps: a protein is dispersed into water, after the protein is fully hydrated, an aqueous phase protein solution is obtained, an oil phase is added, emulsification is performed, and therefore the stable-protein high-internal-phase oil-in-water emulsion is obtained. The method disclosed by the invention does not need any coagulants or surfactants, and the obtained high-internal-phase oil-in-water emulsion has good viscoelasticity, high heat stability and storage stability, and an excellent protection or controlled release effect on the oil phase; and the emulsion has good gelling performance, strong plasticity and remoldability, facilitates further processing, and has good application prospects in the fields of chemical products, daily chemicals, pharmaceuticals, food and healthcare products.

The invention relates to a mesoporous nano silicon ball compound targeting drug delivery system as well as a preparation method and application thereof. The preparation method of the mesoporous nano silicon ball compound targeting drug delivery system comprises the following steps: 1) preparing amino-functionalized drug loading mesoporous silicon dioxide microspheres; 2) preparing hyaluronic acid-hydrosulphonyl polypeptide-adriamycin (HA-RGD-DOX); 3) preparing mesoporous microsphere-hyaluronic acid-hydrosulphonyl polypeptide-adriamycin--paclitaxel (MSNs-HA-RGD-DOX_PTX); and 4) preparing fluorescent marker modified mesoporous microsphere-hyaluronic acid-hydrosulphonyl polypeptide-adriamycin--paclitaxel compound (MSNs-HA-RGD-DOX-PTX). The mesoporous nano silicon ball compound targeting drug delivery system has the beneficial effects that firstly multi-targeting synergistic drug delivery is realized, multiple tumour cells and tissues can be killed, and reversal drug resistance is good; secondly, blood stability is excellent; thirdly, invisibility, drug release degree and controlled release properties are good; fourthly, in vivo tracing function is good; and fifthly, the mesoporous nano silicon ball compound targeting drug delivery system has good general applicability.

The invention discloses a nutrient release rate adjustable plant oil coated controlled-release fertilizer and a preparation method thereof. The preparation method comprises the following step: base on total weight of a coating frame substances, firstly co-mixing and polymerizing 1-10 percent of a pore-foaming agent, 1-18 percent of a film forming aid paraffin, 0.01-0.6 percent of an organic metal catalyst and plant oil polyol to prepare a coating material A; uniformly and simultaneously spraying the coating material A and polyisocyanate on the surface of a core fertilizer in a rotational flow-spraying fluidized bed on the bottom side; performing an in-situ polymerization reaction to generate a uniform high-molecular coating layer on the surface of the core fertilizer, wherein the coating frame substances are the plant oil polyol and the polyisocyanate of which the weight ratio is 1:(0.5-1.5). The preparation method disclosed by the invention has innovation in coating material selection, coated fertilizer nutrient release performance regulation, coating material co-mixing and polymerization process and coating process; the prepared controlled-release fertilizer is stable in quality, complete in coating, controllable in nutrient release rate, low in energy consumption in the coating process and simple and easy to operate in process.

The invention relates to a novel passive targeting nano emulsion with skin whitening effect and a preparation method thereof. The invention uses a novel passive targeting transdermal delivery dosing system TDDS-nano emulsion as a carrier of a function component for whitening or lighting the skin, uses different physical and chemical properties, action mechanism and actual effect of each skin whitening function component, especially the action advantages of certain novel skin whitening function components, and provides skin whitening effect nano emulsion systems with two joint applications in morning and evening matched with each other. The two joint applied nano emulsion systems not only have minimum spherical grains, extremely even distribution of nano-scale grains, remarkable passive targeting function, good transdermal absorption and strong penetrability, but also have extremely even, exquisite, smooth and glossy texture of the nano emulsion, is quite comfortable after coating on the face or the skin, has no stimulus and good stability; and the nano is light yellow, beautiful in appearance, bright and transparent, clear and crystalline, has light opalescence, and is adhesive but not sticky, thick but not heavy, oily but not greasy.

The invention provides a chitosan coated alga bioorganic fertilizer and a preparation method thereof. The chitosan coated alga bioorganic fertilizer is obtained by adopting a process combining high efficiency physical fragmentation with a chemical processing technology to extract physiological active substances and nutrients of algae, adding zymocytes with the synergism to alga residues, preparing an alga organic fertilizer in an aerobic fermentation mode, adding proper amounts of nitrogen phosphorous potassium, trance elements and functional bacteria, mixing alga extracts with the alga organic fertilizer, freeze-drying, and spraying the obtained alga bioorganic fertilizer with chitosans and a sodium alginate solution. The organic fertilizer which contains various biological growth promoters can improve utilization rates of the nutrients by crops and increase endurances and validities of effective components, and also can increase ventilation and coalescence capabilities of soil, obviously promote the formation of granule structures of the soil, slowly release the nutrients, satisfy demands of plants of different growth stages, and generate obvious positive effects on the crop maturation, output and quality improvements, disease and insect pest resisting and the like.

The invention provides a highly active biological water preservation slow release compound fertilizer. The special compound fertilizer is prepared by compounding the ordinary fertilizer with microelements, then a certain amount moderate organic minerals, high water-absorbent resins, humic acids, and biological preparation are crushed and mixed into 100 mesh to 350 mesh to obtain compound powder preparation and subsequently the special compound fertilizer is placed into a granulator, and added with water with a mass ratio of 0.1 to 1 to the compound fertilizer. At last, the compound powder preparation is added into the granulator and the obtained mixtures are granulated and dried to obtain the highly active biological water preservation slow release compound fertilizer. The adoption of ordinary nitrogen, phosphor, and potassium as main materials, and mix of croelements according to requirements for soil fertilizer test and plants to adjust the formula, the highly active biological water preservation slow release compound fertilizer can enhance the effective utilization of fertilizer, lower the pollution to soil, and facilitate the growth of vegetables. The application of the product to the agricultural and forestry production can enhance the utilization of fertilizer by above 60 percent and lower the used amount of fertilizer by 50 percent, reduce the pollution to soil, and enhance the yield and quality of crops.

The invention relates to a special controlled release fertilizer and preparation method for rice, belonging to technical field of slow release and controlled release fertilizer. The invention is characterized in that the invention remix accurately the 5% and 6% of thermoplastic resin membrane urea, the sulfur membrane urea with the potassium chloride compound fertilizer, the potassium chloride and the zinc sulfate according to fertilizer requirement of the rice to form the special formulation of controlled release fertilizer for rice. The invention has the advantages that the nutrient release law of the controlled release fertilizer is matched with the nutrient absorption law of the rice, the controlled release fertilizer costs can be decreased, furthermore, after fertilizing once the controlled release fertilizer before transplanting of rice, no supplementary fertilizer is needed, the labor intensity and worker costs of farmer can be also reduced.

The invention relates to an aqueous polymer-paraffin wax twolayer coating controlled release fertilizer and a preparation method thereof. The coated controlled release fertilizer consists of a fertilizer core and a coating outside the fertilizer core, wherein the coating comprises a paraffin wax film and a polymer film which is arranged on the paraffin wax film and is formed by a composite coating agent containing aqueous polymer emulsion and biodegradable natural macromolecules.

The invention discloses methods for a straw liquefied coating liquid and a coated controlled-release fertilizer. The preparation method of the coating liquid comprises the steps: mixing straw, a liquefying agent, an acidic catalyst and a surfactant, carrying out a reaction, and removing a residue in the reaction system, to obtain a filtrate which is a straw liquefied product; and then carrying out a mixing reaction of the straw liquefied product with polyether polyol, an alkaline catalyst and an auxiliary agent, and thus obtaining the straw liquefied coating liquid. The preparation method of the coated controlled-release fertilizer comprises the steps: preheating fertilizer granules, then simultaneously atomizing the straw liquefied coating liquid and a curing agent onto the surface of the fertilizer granules, to obtain the straw liquefied coated controlled-release fertilizer. The coated controlled-release fertilizer provided by the invention utilizes compounding of heteropolyacid and inorganic acid to catalyze liquefaction of a straw powder; while the alkaline catalyst in the straw liquefied coating liquid is used for acid-alkali adjustment of the straw liquefied product, the in-situ reaction speed is accelerated, and thus the controlled-release characteristic of the coated controlled-release fertilizer is improved.

The invention relates to an alkyd resin emulsion-wax compound coated controlled release fertilizer and a preparation method thereof. The coated controlled release fertilizer consists of a fertilizer core and a capsule which is outside the fertilizer core, wherein, the capsule comprises a wax capsule, the exterior of the wax capsule has a polymer film that contains an alkyd resin emulsion coated agent and an inorganic layer that is arbitrarily arranged on the polymer film and contains inorganic powders.

The invention discloses a planting method for obtaining good-quality and high-yield cortex moutan. The planting method for obtaining good-quality and high-yield cortex moutan comprises the steps of land selection, land preparation, seedling growing, timely transplanting, land management and the like. When base fertilizer is applied during land preparation, thoroughly decomposed farmyard manure and slow release nutrition particles are applied in a mixed mode, nutrition is comprehensive and balanced, the requirements for nutritional ingredients such as nitrogen, phosphorous, potassium, organic matter and microelements are met during seedling growing of moutan, the controlled release effect is good, the fertilizer efficiency is durable, the utilization rate is high, absorption is easy, the frequency of fertilizer application is reduced, and the emergence rate is increased; during sowing, seed dressing is conducted through modified plant ash, a good growing environment can be provided for growth of seeds, diseases and insect pests can be reduced, and the emergency rate can also be increased. By the adoption of the planting method, the quality of the cortex moutan can be improved, the yield of the cortex moutan can be increased, the cortex moutan can reach the high-quality level, the content of the effective constituent can be increased by over 10%, the yield is increased by over 35%, and the economic benefits of a moutan cortex farmer can be greatly increased; in addition, operation is simple, implementation is easy, cost is low, and the planting method is suitable for large-scale popularization.

The invention relates preparation of castor oil-based coating material and application of the castor oil-based coating material in controlled-release fertilizers. Epoxidized castor oil is prepared from castor oil as a raw material by using a non-solvent method under acid catalysis by using small-molecular carboxylic acid and hydrogen peroxide as modifiers; then, small-molecular alcohols and alcohol amines are used as ring-opening reagents to prepare the modified castor oil coating material 200-400 mgKOH / g in hydroxyl value under the action of a solid acid catalyst. The modified castor oil coating material and isocyanate are used as component A and component B respectively to prepare a modified castor oil coated controlled-release fertilizer by using non-solvent in-situ reaction coating technology. The controlled-release fertilizer is green, the production process of the fertilizer is simple, the controlled release effect is good and stable, and controlled-release fertilizers with different release periods may be prepared by changing coating amount.

The invention belongs to the technical field of emulsions, and discloses a high-internal-phase emulsion of soybean protein isolate-pectin compound stabilized quercetin and a preparation method of thehigh-internal-phase emulsion. The method comprises the following steps: dissolving soybean protein isolate in distilled water to obtain a soybean protein isolate solution; dissolving pectin in distilled water, and adjusting the pH value to obtain a pectin solution; mixing the soybean protein isolate solution with the pectin solution; adjusting the pH value of the solution to 3.0-11.0; mixing the obtained solution with vegetable oil containing quercetin in proportion, then carrying out ultrasonic treatment, and carrying out centrifuging to obtain the high-internal-phase emulsion of soybean protein isolate-pectin compound stabilized quercetin. According to the invention, no surfactant is needed, and the obtained oil-in-water type emulsion is small in particle size, good in viscoelasticity and high in stability and has an excellent protection or controlled release effect on quercetin. The preparation method is low in instrument requirement, the method is simple and is easy to operate, andgood prospects are achieved in application aspects of novel nutrient substance conveying carriers and food structure modification base materials.

A preparation method of konjac glucomannan edible tableware comprises preparing esterification modified products, preparing composite gel, heating, centrifugally degassing, shaping tableware, samming and easing back, and sterilizing. The viscosity, film formation temperature and gel strength of konjac glucomannan sol-gel are easy to control, thereby greatly improving the performance and stability of industrial production. The konjac glucomannan edible tableware makes up the defect in the aspect of quality control of products; and the sensory quality of the konjac glucomannan edible tableware is greatly improved. Furthermore, the main raw material konjac glucomannan adopted in the invention is low in price, thereby not only improving the safety of tatableware but also greatly reducing the production cost of products. The konjac glucomannan edible tableware is a water-resistant and high-temperature resistant edible tableware.

The invention discloses a polyurethane diolame controlled-release fertilizer containing herbicide and a preparation method of the fertilizer, and relates to a diolame controlled-release fertilizer and a preparation method thereof. The polyurethane diolame controlled-release fertilizer containing the herbicide comprises fertilizer grains, wherein the fertilizer grains are externally provided with a polyurethane diolame with the herbicide; the polyurethane diolame containing the herbicide is 1-20% of the mass of the grain fertilizer according to percentage by mass. The polyurethane diolame controlled-release fertilizer containing the herbicide is prepared by putting the fertilizer grains into a sugarcoating machine, starting the sugarcoating machine to preheat, respectively heating a polyurethane diolame liquid A with the herbicide and a polyurethane diolame liquid B with the herbicide, respectively spraying the heated polyurethane diolame liquids A and B on the surface of fertilizer grains, and repeatedly coating for 2-6 times after the polyurethane diolame liquids with the herbicide are reacted and cured. The polyurethane diolame controlled-release fertilizer can well inhibit the growth of field weeds and eliminate field plant weeds, and has the double advantages of herbicide and a controlled-release fertilizer.

The present invention belongs to the technical field of agricultural microbe, and specifically relates to a microbial capsule preparation taking poly-gamma-glutamic acid as a wall material, a preparation method thereof, and applications thereof in preparing microbial pesticides and microbial fertilizers. The microbial microcapsules taking the poly-gamma-glutamic acid as the wall material have good mechanical strength and flexibility, can be applied in microbial embedding medium for good sustained-release ability, can prevent microbial cells from injuries of ultraviolet rays, temperature, acid or base, ionic strength and heavy metal ions, can prevent microbial cells from damages in a production process, and have the advantages of effectively extending the shelf life of the preparation and the like. The microbial microcapsule preparation of the present invention can prepare different microbial microcapsule preparations according to different microbial species, and can effectively control capsule wall thickness and diameter of the microcapsules in the preparation process. The microcapsules of the invention have an embedding rate of more than 90% for microbial cells, and can realize industrial mass production.

The invention provides sericin-alginate compounded hydrogel and a preparation method thereof. The method comprises the steps that 1, silkworm cocoons of bombyx mori silk fibroin deletion type mutation varieties are weighed, extraction is carried out with LiBr or LiCl water solution, dialysis and purification are carried out, concentration is carried out, and a nondegradable sericin water solution with the mass percentage concentration being 1.5% to 10% is obtained; 2, an alginate water solution with the mass percentage concentration being 0.1% to 10% is prepared; 3, in the presence of a cross-linking agent, the sericin water solution and the alginate water solution are mixed in the proportion of (100-0.01):1, and the sericin-alginate compounded hydrogel is prepared, wherein the cross-linking agent comprises an ionic cross-linking agent and / or a covalent cross-linking agent. According to the scheme, the sericin-alginate compounded hydrogel of an interpenetrating polymer network can be obtained, the obtained compounded hydrogel has excellent fluorescence characteristics, deformation memorability and elasticity modulus adjustability and further has good biocompatibility and cell adhesion, and survival, proliferation and migration can be supported for a long time.

The invention relates to water-soluble urea-formaldehyde glue and a preparation method thereof as well as a method for improving strength of water-soluble compound fertilizer granule by the water-soluble urea-formaldehyde glue. The water-soluble urea-formaldehyde glue consists of the following raw material components in parts by weight: 600-800 parts of 37wt% formaldehyde water soluble, 250-400 parts of urea, 1-5 parts of melamine, 1-5 parts of phthalic anhydride, 1-5 parts of sodium hydroxide solution and 15-30 parts of starch. The method for improving the strength of the water-soluble compound fertilizer granule by the water-soluble urea-formaldehyde glue comprises the following steps: in a process of preparing the water-soluble compound fertilizer by an aggregating process, after processes of pelleting, drying and sieving and before a cooling process, spraying the water-soluble urea-formaldehyde glue on the surface of the fertilizer granule. The water-soluble urea-formaldehyde glue disclosed by the invention is low in cost and simple in preparation method; and, after implementing a surface treatment on the water-soluble compound fertilizer granule, the strength of the fertilizer granule is remarkably improved to more than 20N under a precondition of guaranteeing a controlled-release effect, so that the water-soluble urea-formaldehyde glue can completely meet the demand of spouted bed coating.

The invention discloses a chitosan and sulfur coated special sustained-release fertilizer for wheat and a preparation method thereof, which belong to the technical field of controlled-release fertilizer. The fertilizer is based on the nutrient absorption law of wheat. The fertilizer is obtained by preparing 5-percent chitosan coated urea, 6-percent chitosan coated urine, sulfur coated urine, monoammonium phosphate, potassium chloride, humic acid and ethylene diamine tetraacetic acid (EDTA) chelate iron according to a specified mixing ratio, fully mixing, weighing and packaging. The special controlled-release fertilizer has the advantages of high nutrient utilization rate, environment pollution reduction due to degradability of the coating of the fertilizer, low price, consistence between nutrient release and wheat absorption law, labor cost conservation and improvement on quality of wheat.

The invention discloses a paddy-rice controlled-release fertilizer, and a preparation method and application thererof. The paddy-rice controlled-release fertilizer is prepared by employing potassium dihydrogen phosphate, urease and nitrification-inhibitor-containing slow-release urea as fertilizer core, attapulgite clay as an inner cladding and paraffin as an outer cladding, employing a fusion spraying coating method and performing granulation and sieving. The paddy-rice controlled-release fertilizer is simple in preparation method, low in cost, good in surface fineness, long in fertilizer conservation time and convenient to use, is capable of effectively improving nitrogen and phosphorus pollution conditions in farmland pollutants, provides fertilizer efficiency needed by various growth periods of paddy rice by applying to soil before transplantation of paddy rice, and helps to reduce excess fertilizing and repeated fertilizing, reduce fertilizing cost and improve output and quality of paddy rice.

The invention discloses a chitosan-coated vitamin C micro-capsule. The chitosan-coated vitamin C micro-capsule is prepared from, by mass, 0.4-2.5 parts of vitamin C, 0.02-0.04 part of anhydrous magnesium sulfate, 15.5-27.0 parts of soybean oil, 0.4-0.6 part of Span 80, 0.6-1.2 parts of glacial acetic acid, 0.6-1.0 part of chitosan, 1.6-2.9 parts of polysorbate 80, 0.4-0.6 part of curing agents and the balance deionized water. The invention further provides a preparing method for the chitosan-coated vitamin C micro-capsule. The chitosan-coated vitamin C micro-capsule prepared by adopting a multiphase emulsion method is of a regular spherical multi-core structure, and the coverage rate of vitamin C can be 20-50%. The prepared vitamin C micro-capsule effectively prevents the vitamin C from being oxidized, and has good biocompatibility and degradability.

The invention discloses a sightseeing greenhouse succulents improvement matrix and its preparation method. The matrix is prepared from the following raw materials, by weight, 30-50 parts of a light material, 40-60 parts of an organic matter, 4-8 parts of an inorganic fertilizer, 5-10 parts of bentonite, 0.5-1.5 parts of a microelement fertilizer and 0.5-1.5 parts of a plant protectant. The light material is one of components selected from vermiculite, perlite, ceramsite and volcanic or an arbitrary combination of two of the components. The organic matter is one of components selected from soybean cake, rape seed cake, cottonseed cake, leaf mould and bone meal or an arbitrary combination of two of the components. The inorganic fertilizer is obtained by mixing ammonium thiosulfate, monopotassium phosphate, potassium nitrate, ammonium phosphate and potassium sulphate. The microelement fertilizer is obtained by mixing ferrous sulphate, ammonium molybdate, manganese sulfate, zinc sulfate and copper sulphate. The plant protectant is obtained by mixing alpha-naphthylacetic sodium salt, diethyl aminoethyl hexanoateDA-6, 70 wt% of thiophanate-methyl and hymexazol. By the use of the improvement matrix, soil can be improved, fertilizers can be saved, the environment can be protected, and rooting speed of succulents can be raised.

The invention discloses functional sericin hydrogel as well as a preparation method and an application thereof. According to the method, a silkworm cocoon of a specific bombyx mori silk fibroin missing type mutant variety is adopted, a sericin water solution is extracted, ultrasonic treatment is performed, and the sericin hydrogel with new characteristics is obtained. The sericin hydrogel has hightransparency; the sericin hydrogel has a microstructure different from conventional hydrogel, hydrogel micropores are orderly arranged from large to small and from small to large; the functional sericin hydrogel has the characteristics of excellent elasticity, injectability and controllable gelling time; the sericin hydrogel has certain application value in the aspect of drug release control; thesericin hydrogel has higher affinity for cells and can support adhesion and proliferation of the cells; the sericin hydrogel and a 3D porous sericin biological scaffold obtained through freeze dryingof the sericin hydrogel can serve as extracellular matrixes to support cell growth and promote exchange of nutritional substances and can be applied to repairing of damage of multiple tissues and treatment of diseases.

The present invention relates to a preparation method of a pH sensitive and photothermal therapeutic probe based on a metal organic framework ZIF-8. ZIF-8 is a basic unit composed of 2-methylimidazoleand a metal atom Zn, wherein each Zn atom is coordinated with N atoms on four 2-methylimidazole rings to form a tetrahedral-like structure cluster, the clusters are used as nodes, and then a 2-methylimidazole ring can be further connected to form a hexahedral-like cage structure; particle size and porosity of a MOF structure can be further adjusted by use amount of 2-methylimidazole and zinc acetate to obtain the MOF structures with different morphologies; and at the same time, in a synthesis process of ZIF-8 MOF, by directly adding an IR-780 solution, IR-780 can be directly encapsulated during the synthesis process to obtain a target probe. In the synthesis process, the IR-780 can be directly encapsulated, and the metal organic framework ZIF-8 has broad application prospects in cancer treatment.

The invention discloses a potential of hydrogen (pH) response random copolymer based on poly-beta amino ester and a preparation method and application thereof. Firstly, polylactic acid with two ends sealed with hydroxide radicals is synthesized through a solution polymerization method, propylene serves as a macro-monomer after acidification, and a pH response amphiphilic copolymer is prepared through the Michael gradual addition reaction. The proportion of functional groups in the polymer molecule can be regulated. The synthetic process is simple, and the production rate is high. By means of a polymeric micelle obtained through a dialysis method and with a hydrophobic group (polylactic acid) and a pH response group (poly-beta amino ester) forming a kernel and a hydrophilic group forming acasing, water slight-solubility anti-cancer drugs can be coated into the kernel of the micelle, and the drugs can be slowly released in low quantity under neutral or weak alkaline conditions and can be quickly and controllably released under weakly acidic conditions.

The invention relates to the field of pharmaceutical preparations and particularly provides a controlled release tablet of metformin hydrochloride and a preparation method of the controlled release tablet. The controlled release tablet provided by the invention contains a tablet core, an insoluble semi-permeable membrane and a drug release micro-pore, wherein the tablet core contains metformin hydrochloride, an adhesive, a release regulator, an absorption accelerant and a lubricating agent. The metformin hydrochloride in the controlled release tablet provided by the invention can be stably released at a constant speed, so that absorption of drugs is more facilitated, and a better in vivo pharmacokinetic curve is realized. Moreover, the preparation method of the controlled release tablet is simple and easy in process, and the technical defect of poor compressibility of the tablet is solved.