Sericin-alginate compounded hydrogel and preparation method thereof
A technology of composite hydrogel and sericin, which is applied in the field of sericin-alginate composite hydrogel and its preparation, can solve the problem of increasing material production cost and workload, lack of cell adhesion performance and controllable Degradability and other issues, to achieve good drug release ability, reduce surgical trauma, support adhesion and proliferation effects
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[0059] Example 1 Preparation of sericin-alginate composite hydrogel provided by the present invention
[0060] 1. Selection of silkworm cocoons:
[0061] Silkworm cocoons of silkworm silk fibroin-deficient mutant varieties were selected (purchased from the Sericulture Research Institute of the Chinese Academy of Agricultural Sciences, and the silkworm silk fibroin-deficient mutant varieties were preserved in the National Silkworm Resource Preservation Center of the Sericulture Research Institute of the Chinese Academy of Agricultural Sciences, preservation number (or commodity number) 185Nd -s, 140Nd-s, 139Nd-s) as raw materials, the main chemical composition is: sericin.
[0062] 2. Extraction and separation of sericin
[0063] 1) Weigh 1 g of silkworm cocoons (purchased from the Institute of Sericulture, Chinese Academy of Agricultural Sciences) and cut them into 1 cm 2 The fragments were placed in a clean beaker, washed 3 times with ultrapure water, and centrifuged at 350...
preparation example 1
[0078] Sericin aqueous solution and CaCl 2 The aqueous solution ionic cross-linking agent is mixed to form mixed liquid A, and the alginate aqueous solution and glutaraldehyde covalent cross-linking agent are mixed to form mixed liquid B, and then mixed liquid A and mixed liquid B are mixed (for example, with mixed liquid The two syringes of A and mixed solution B were connected by Luer and pushed each other dozens of times to mix well, and then stood at 37°C for 5 minutes to form sericin-alginate composite hydrogel.
preparation example 2
[0080] Sericin aqueous solution and Ca 2 SO 4 Mix the ionic cross-linking agent to form a mixed solution A, mix the alginate aqueous solution and the glutaraldehyde covalent cross-linking agent to form a mixed solution B, then mix the mixed solution A and the mixed solution B in equal volumes, mix well and place at 37 °C for 0.5 hour to obtain sericin-alginate composite hydrogel.
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