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Nano-lipid carrier for embedding vitamin A alcohol and preparation method thereof

A technology of nano-lipid carrier and vitamin, which is applied in the field of skin care products, can solve the problems of not being able to use skin care products, and achieve the effects of avoiding oxidation, low irritation, and good drug release

Active Publication Date: 2018-08-28
上海格兰化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the above patent can embed vitamin A, it is used to provide consumers with different nutrition and cannot be used in skin care products
At present, there is no report on the use of nano-lipid carrier to embed vitamin A alcohol and apply it to skin care products.

Method used

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  • Nano-lipid carrier for embedding vitamin A alcohol and preparation method thereof
  • Nano-lipid carrier for embedding vitamin A alcohol and preparation method thereof
  • Nano-lipid carrier for embedding vitamin A alcohol and preparation method thereof

Examples

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Effect test

Embodiment 1

[0046] Example 1: A nano-lipid carrier embedding vitamin A alcohol, the components and their corresponding weight percentages are shown in Table 1, and the preparation process refers to figure 1 , and obtained by the following steps:

[0047] Step 1, mix macadamia soybean oil and palm wax and heat it at a constant temperature to 85°C, then add vitamin A alcohol and mix evenly to form an oil phase;

[0048] Step 2, water, alcohol solvent, non-ionic surfactant and phospholipid are heated to 85°C at a constant temperature to form an aqueous phase;

[0049] Step 3, add the oil phase to the water phase and mix evenly, keep the temperature at 85°C to form a mixed phase;

[0050]Step 4, using a homogenizer to pre-emulsify the mixed phase at a speed of 8000 rpm and an emulsification time of 30 minutes to form a mixed phase emulsion;

[0051] Step 5, feed the mixed-phase emulsion into a high-pressure homogenizer, pressurize the high-pressure homogenizer to 600 bar, and circulate 3 ti...

Embodiment 2-9

[0052] Example 2-9: A nano lipid carrier embedding vitamin A alcohol, the difference from Example 1 is that each component and its corresponding weight percentage are shown in Table 1.

[0053] Each component and weight percent thereof in table 1 embodiment 1-9

[0054]

[0055]

Embodiment 10-19

[0056] Examples 10-19: A nano lipid carrier embedding vitamin A alcohol, the difference from Example 1 is that each component and its corresponding weight percentage are shown in Table 2.

[0057] Each component and weight percent thereof in table 2 embodiment 10-19

[0058]

[0059]

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Abstract

The invention discloses a nano-lipid carrier for embedding vitamin A alcohol and a preparation method of the nano-lipid carrier for embedding the vitamin A alcohol, relates to the field of skin-care products, and solves the problems of high irritation and poor stability caused by directly applying the vitamin A alcohol to the skin-care products. The nano-lipid carrier for embedding the vitamin A alcohol comprises the following components in weight by percentage: 8 to 12% of Hawaiian soybean oil, 8 to 12% of palm wax, 1 to 5% of vitamin A alcohol, 8 to 12% of a nonionic surfactant, 1 to 3% of an alcohol solvent, 0.1 to 1% of phospholipid and the balance of water. According to the invention, the raw materials of the Hawaiian soybean oil, the palm wax, the surfactant and the like are mutuallymatched for embedding the vitamin A alcohol, the nano-lipid carrier for embedding the vitamin A alcohol is applied to the skin-care products, so that the skin-care products have the advantages of lowirritation, good drug release and the like and oxidation of the vitamin A alcohol is avoided; an embedding system in the invention can well embed the vitamin A alcohol, and the embedding rate is close to 100%; the interface potential value of the nano-lipid carrier is between minus 33mV to minus 49mV, and the nano-lipid carrier further has good stability and dispersion.

Description

technical field [0001] The invention relates to the field of skin care products, more specifically, it relates to a nano-lipid carrier embedding vitamin A alcohol and a preparation method thereof. Background technique [0002] Vitamin A is A acid, A ester and A alcohol. Its main effect on the skin is anti-wrinkle and anti-aging. It can improve rough skin, make the skin smooth, and strengthen the metabolic function of the skin. Anti-aging purposes. Since the direct use of A acid will irritate the skin, if you want to use vitamin A in skin care, you should mainly use A alcohol and A ester. Once the alcohol or ester is absorbed by the skin, it can also be converted into A acid to achieve the effect of skin care. Since vitamin A absorbs light, it is easy to deteriorate due to light irradiation and oxidation, so it needs to be protected. If it is used for skin protection, embedding it in a carrier will be a good choice. Among them, the lipid carrier is the most superior. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/92A61K8/86A61K8/60A61K8/55A61K8/14A61Q19/00A61Q19/08
CPCA61K8/14A61K8/553A61K8/604A61K8/671A61K8/86A61K8/922A61K2800/413A61K2800/56A61K2800/72A61Q19/00A61Q19/08
Inventor 陈宝祺庞振宜潘颀钧管岚
Owner 上海格兰化妆品有限公司
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