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Selenium quantum dot/silicon dioxide/copper sulfide nanocomposite particle, preparation and application thereof

A technology of nanocomposite particles and silicon dioxide, which can be used in wave energy or particle radiation treatment materials, drug combinations, medical preparations of non-active ingredients, etc., can solve the problems of cytotoxicity and side effects, inability to completely remove cancer cells, etc., and achieve The synthesis process is simple, the preparation period is shortened, and the storage is convenient

Inactive Publication Date: 2017-12-15
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing cancer treatment methods mainly include surgery, chemotherapy and radiotherapy, etc., but these methods have drawbacks, cannot completely remove cancer cells, and will cause serious toxic side effects to normal tissues and cells of the body

Method used

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  • Selenium quantum dot/silicon dioxide/copper sulfide nanocomposite particle, preparation and application thereof
  • Selenium quantum dot/silicon dioxide/copper sulfide nanocomposite particle, preparation and application thereof
  • Selenium quantum dot/silicon dioxide/copper sulfide nanocomposite particle, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A selenium quantum dot / silicon dioxide / copper sulfide nanocomposite particle (Se@SiO 2 -FA-CuS), the composite structure nanoparticles use selenium quantum dots as the core and porous silica as the shell, then carry out amination modification on the surface, and then graft the targeting agent folic acid, and finally adsorb on the surface through electrostatic interaction. Ultrasmall CuS nanoparticles with photothermal function.

[0039] (1) The preparation method of this selenium quantum dot / silicon dioxide / copper sulfide nanocomposite particle comprises the following steps:

[0040] (1-1)Cu 2-X Preparation of Se nanocrystals: Take two three-neck bottles and weigh 43.5g selenium powder (A bottle) and 49.5g cuprous chloride (B bottle), add 6mL oleic acid into A bottle, start stirring and heat to 60°C Nitrogen for 5 minutes, then rapidly heated to 280°C with nitrogen, and kept for 30 minutes; add 5mL oleic acid and 5mL oleylamine to bottle B, start stirring and heat to ...

Embodiment 2

[0056] This embodiment is basically the same as Example 1, the difference is that the addition of the Cu dispersed in n-hexane in this embodiment 2-X The amount of Se nanocrystals was 3.3 mL.

Embodiment 3

[0058] This example is basically the same as Example 1, except that the amount of TEOS added in this example is 0.16 mL.

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Abstract

The invention relates to a selenium quantum dot / silicon dioxide / copper sulfide nanocomposite particle, preparation and application thereof. The nanocomposite particle has a chemical formula of Se@SiO2-FA-CuS, selenium quantum dot is adopted as the core, porous silicon dioxide is taken as the shell, amination modification is carried out on the shell surface, and a targeting reagent folic acid is grafted, and then copper sulfide nanoparticles are adsorbed on the shell surface through electrostatic effect. Compared with the prior art, the Se@SiO2-FA-CuS nanocomposite particle provided by the invention has a novel structure and good photothermal performance, has broad application prospects in terms of drug loading, photothermal therapy and targeted transportation, can achieve targeted transportation of anticancer drugs and photothermal reagents to cancer sites, effectively kills cancer cells while reducing the toxic and side effect on normal tissues and cells, further improves the therapeutic effect, and is of enormous potential in promotion of chemotherapy and photothermal therapy (PTT) combined application and enhancement of cancer treatment efficacy.

Description

technical field [0001] The invention belongs to the technical field of anticancer drug carriers, and relates to a selenium quantum dot / silicon dioxide / copper sulfide nanocomposite particle and its preparation and application. Background technique [0002] In recent years, with the aggravation of environmental pollution and the impact of changes in people's lifestyles, cancer cases have increased at an alarming rate, and cancer is increasingly threatening people's health. The existing cancer treatment methods mainly include surgery, chemotherapy and radiotherapy, etc., but these methods have drawbacks, cannot completely remove cancer cells, and will cause serious toxic side effects to normal tissues and cells of the body. At the same time, photothermal therapy (PTT) based on nanomaterials and nanotechnology has attracted widespread attention. Photothermal materials can convert near-infrared light into thermal effects and kill cancer cells through local high temperature to imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/69A61K47/54A61P35/00
CPCA61K9/0002A61K9/0009A61K31/704A61K41/0052A61K2300/00
Inventor 王烨颖刘锡建陆杰孔文艳刘晓迪张玲樊凡凡张帅张怡玲
Owner SHANGHAI UNIV OF ENG SCI
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