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Medical dressing with drug loading function and preparation method thereof

A functional and drug-loading technology, which is applied in medical science, absorbent pads, filament/thread forming, etc., can solve problems not related to medical use, and achieve the effects of excellent drug control release ability, simple implementation, and easy industrial application

Inactive Publication Date: 2017-02-01
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

but not medical

Method used

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  • Medical dressing with drug loading function and preparation method thereof
  • Medical dressing with drug loading function and preparation method thereof
  • Medical dressing with drug loading function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Dissolve PVA in distilled water at 70-80°C to obtain a 13w / v solution, and after cooling, mix in a 3mg / mL graphene oxide aqueous solution. The volume ratio of PVA solution and graphene oxide solution is 10:1, then add 3mg / mL norfloxacin aqueous solution, the volume ratio of PVA solution and drug solution is 20:1. The resulting solution is an electrospinning solution.

[0036] The output voltage of the high-voltage power supply was adjusted to 15KV, the curing distance (the distance between the receiving device and the nozzle) was adjusted to 15cm, and the electrospinning time was 30min.

Embodiment 2

[0038] Dissolve PVA in distilled water at 70-80°C to obtain a 10w / v solution, and after cooling, mix in 2mg / mL graphene oxide aqueous solution. The volume ratio of PVA solution and graphene oxide solution is 10:1, then add 3mg / mL norfloxacin aqueous solution, the volume ratio of PVA solution and drug solution is 10:1. The resulting solution is an electrospinning solution.

[0039] The output voltage of the high-voltage power supply was adjusted to 15KV, the curing distance (the distance between the receiving device and the nozzle) was adjusted to 15cm, and the electrospinning time was 30min.

Embodiment 3

[0041] Dissolve PVA in distilled water at 70-80°C to obtain a 13w / v solution, and after cooling, mix in a 3mg / mL graphene oxide aqueous solution. The volume ratio of PVA solution and graphene oxide solution is 10:1, then add 3mg / mL norfloxacin aqueous solution, the volume ratio of PVA solution and drug solution is 20:1. The resulting solution is an electrospinning solution.

[0042] The output voltage of the high-voltage power supply was adjusted to 10KV, the curing distance (the distance between the receiving device and the nozzle) was adjusted to 10cm, and the electrospinning time was 30min.

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PUM

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Abstract

The invention discloses a preparation method of a medical dressing with a drug loading function. The method includes the following steps that firstly, an electrospinning solution containing drug is prepared; secondly, electrostatic spinning is conducted; thirdly, a prepared product is subjected to drug controlled release testing. The prepared composite medical dressing containing antibacterial drug / PVA / oxidized graphene is excellent in processing performance. The prepared product has excellent drug controlled release capacity. The method is simple in process, low in cost and easy to use and popularize widely in the medical material field.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a medical dressing with a drug-loading function and a preparation method thereof. Background technique [0002] The traditional method of treating wounds and burns is to apply antibacterial drugs on the wound, and then wrap it with gauze, which can absorb the wound exudate, prevent bacterial infection, reduce scar formation, and prevent secondary damage, but the contact between the drug and the wound also brings Some problems have been solved, such as too high drug concentration has a certain impact on the normal tissues and organs of the human body, and too low drug concentration cannot achieve the effect of treatment and prevention. Traditional gauze needs to be replaced frequently because it is easily contaminated, which undoubtedly aggravates the suffering of patients. [0003] The advent of degradable medical dressings with drug-loading functions has solved these problems. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/18A61L15/44D01F1/10D01F6/50D01D5/00
CPCA61L15/24A61L15/18A61L15/44A61L15/46A61L2300/216A61L2300/404A61L2300/406A61L2300/602D01D5/003D01D5/0092D01F1/10D01F6/50C08L29/04
Inventor 庞娟周小杰黄晶
Owner JINLING INST OF TECH
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