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Drug controlled-release mesoporous silicon nanoparticles and preparation method thereof

A technology of silicon nanoparticles and nanoparticles, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations of non-active ingredients, etc., can solve the problems of poor pH response and drug controlled release performance, and achieve good effects , good drug release performance, and good responsiveness

Active Publication Date: 2019-11-15
HUNAN PROVINCIAL TUMOR HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a drug controlled release mesoporous silicon nanoparticle and its preparation method, to at least solve the pH of the drug controlled release system in the prior art Poor responsiveness and poor drug release performance

Method used

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  • Drug controlled-release mesoporous silicon nanoparticles and preparation method thereof
  • Drug controlled-release mesoporous silicon nanoparticles and preparation method thereof
  • Drug controlled-release mesoporous silicon nanoparticles and preparation method thereof

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Embodiment 1

[0035] A preparation method of drug controlled-release mesoporous silicon nanoparticles according to an embodiment of the present invention, the preparation method comprising the following steps:

[0036] (1) Synthesis of mesoporous silicon nanoparticles

[0037] Weigh 0.50g of cetyltrimethylammonium bromide (CTAB) and dissolve it in 240mL of deionized water, add 1.75mL of 2.0M NaOH solution, adjust the temperature to 70°C, keep warm for 30min, and quickly add 2.75mL of Ethyl silicate (TEOS), after 1 min, add 2.50 mL of ethyl acetate, continue to stir for 2 h, until a white precipitate appears, wash with ultrapure water and ethanol (three times) after centrifugation, and vacuum dry overnight at 60 ° C to obtain a white solid Mesoporous silicon nanoparticles;

[0038] (2) Amination modification of mesoporous silicon nanoparticles

[0039] Weigh 100 mg of the prepared mesoporous silicon nanoparticles, add 50 μL of 3-aminopropyltriethoxysilane (APTES), reflux in 10 mL of dry to...

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Abstract

The invention discloses drug controlled-release mesoporous silicon nanoparticles and a preparation method thereof. The preparation method comprises the following steps: (1) adding 3-aminopropyltriethoxysilane into mesoporous silicon nanoparticles, carrying out a reflux reaction under the protection of nitrogen by taking toluene as a solvent, washing with ultrapure water and ethanol after the reaction is finished, and carrying out vacuum drying to obtain aminated mesoporous silicon nanoparticles MSN-NH2; (2) dissolving the aminated mesoporous silicon nanoparticles in acetonitrile, adding 1-pyreneformaldehyde for a reaction, centrifuging after the reaction is finished, washing with ultrapure water and ethanol, and performing vacuum drying to obtain MSN-N = CH-Py; and (3) taking MSN-N = CH-Py, adding a to-be-loaded drug solution to react, adding beta-cyclodextrin to continue to react after the reaction is finished, centrifuging after the reaction is finished, washing with ultrapure waterand ethanol, and carrying out vacuum drying to obtain the product. The drug controlled-release mesoporous silicon nanoparticles disclosed by the invention have good responsiveness to pH, and have gooddrug loading capacity and drug controlled-release performance.

Description

technical field [0001] The invention relates to the technical field of drug controlled release, in particular to a drug controlled release mesoporous silicon nanoparticle and a preparation method thereof. Background technique [0002] Edaravone (ED) is an effective free radical scavenger, which is widely used clinically to treat ischemic stroke. According to reports, ED also has a protective effect in IRI (Ischemia Reperfusion Injury, Ischemia-Reperfusion Injury) of lung, kidney, heart, liver and other organs. ROS (reactive oxygen species, reactive oxygen species) damage can cause cell edema and apoptosis. A large number of studies have shown that ED can reduce apoptosis by clearing ROS in vivo. Shimoda M found that Edaravone can alleviate HIRI (hepatic ischemia-reperfusion injury) by inhibiting apoptosis. [0003] Mesoporous silicon nanoparticles (MSNs) have been widely used in the field of drug delivery in recent years due to their large specific surface area, easy surfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/52A61K31/4152A61P9/10
CPCA61K47/6951A61K47/52A61K31/4152A61P9/10Y02A50/30
Inventor 杨金凤郑楚眉赵述武
Owner HUNAN PROVINCIAL TUMOR HOSPITAL
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