The invention provides an adsorption and rectification combined technology for preparation of ultra-pure 1,1,1,2,3,3,3-heptafluoropropane. An ultra-pure 1,1,1,2,3,3,3-heptafluoropropane crude product is first subjected to adsorption treatment and then subjected to rectification and purification. The prepared 1,1,1,2,3,3,3-heptafluoropropane has purity reaching 99.99%, even 99.999% or higher, and any alkene impurity less than 5 ppm. The prepared ultra-pure 1,1,1,2,3,3,3-heptafluoropropane can be used as a medicinal aerosol propellent.